Development and clinical application of quantitative visual evaluation with comprehensive light emitting diode stimulation for patients with severe visual impairment.

• Project/Area Number: 18K16943
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: 独立行政法人国立病院機構(東京医療センター臨床研究センター)
• Principal Investigator: Fujinami Yu 独立行政法人国立病院機構(東京医療センター臨床研究センター), 視覚研究部, 研究員 (50815173)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 遺伝性網膜疾患 / 視機能評価 / 重度視覚障害

Outline of Final Research Achievements

Visual impairment due to severe retinal diseases is a serious condition with direct negative impact on quality of life. In recent years, the introduction of treatments for severe visual impairment has become a reality; however, there is a lack of validated evaluation methods for determining the indications for intervention and the treatment effects.　In this study, the international collaboration led by the National Institute of Sensory Organs (NISO), Tokyo Medical Center, developed a stimulation algorithm using the advanced integrated LED monitor stimulation technology to establish a comprehensive and quantitative assessment system for a group of severely affected patients (defined as four conventional categories; counting fingers, hand motion, light perception, and no light perception) that was difficult to measure quantitatively with conventional vision tests.

Academic Significance and Societal Importance of the Research Achievements

現在、重度視覚障害患者に対する治療治験は国内外で進行しており、遺伝子治療をはじめとする先鋭的治療において、包括的・定量的評価系の導入が切に迫られている。本研究において、重度視覚障害患者に特化した汎用性の高い包括的視機能評価法が構築された事で、詳細で正確な病状把握が可能となった。開発されたアルゴリズムは国際基準・国際規格で構成される為、今後計画される世界における先鋭的治療の導入・効果判定に対して運用が計画されており、次世代型視機能評価ツールの登場により、絶大なインパクトを与える事が期待される。

Research Products

• [Int'l Joint Research] Seoul National University(韓国)
• [Int'l Joint Research] Southwest Hospital/Peking union medical college hospital/Henan Eye Institute(中国)
• [Int'l Joint Research] Universidad de Chile(チリ)
• [Int'l Joint Research] University College London, London(英国)
• [Int'l Joint Research] ohannes Kepler University Linz/Medical University of Graz(オーストリア)
• [Int'l Joint Research]
• [Int'l Joint Research] UCL institute of ophthalmology(英国)
• [Int'l Joint Research] Southwest Hospital/Peking Union Medical College Hospital/Henan Eye Institute, Henan Eye Hospital(中国)
• [Int'l Joint Research] Lion Eye Institute(オーストラリア)
• [Int'l Joint Research] Singapore National Eye Centre(シンガポール)
• [Int'l Joint Research] SNUBH/Seoul National University Hospital/SUBH(韓国)
• [Int'l Joint Research]
• [Int'l Joint Research] UCL Institute of Ophthalmology/Cambridge Research Systems(英国)
• [Int'l Joint Research] Peking Union Medical College Hospital/Third Military Medical University/Henan Eye Hospital(中国)
• [Int'l Joint Research] Singapore National Eye Centre(シンガポール)
• [Int'l Joint Research] Seoul National University/Soonchunhyang University(韓国)
• [Journal Article] Prediction of causative genes in inherited retinal disorder from fundus photography and autofluorescence imaging using deep learning techniques. (2021)
  • Author(s): Fujinami-Yokokawa Y, Ninomiya H, Liu X, Yang L, Pontikos N, Yoshitake K, Iwata T, Sato Y, Hashimoto T, Tsunoda K, Miyata H, Fujinami K; Japan Eye Genetics Study (JEGC) Group.
  • Journal Title: Br J Ophthalmol Volume: - Issue: 9 Pages: 1272-1279
  • DOI: 10.1136/bjophthalmol-2020-318544
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] KCNV2-associated Retinopathy: Detailed Retinal Phenotype and Structural Endpoints - KCNV2 Study Group Report 2 (2021)
  • Author(s): Georgiou M, Fujinami K,,..., Fujinami-Yokokawa Y, Leo SM, Liu X, Tsunoda K, Hayashi T, Jimenez-Rolando B, Martin-Merida MI, Avila-Fernandez A, Carre?o E, Garcia-Sandoval B, Carmen A, Sharon D, Kohl S, Huckfeldt RM, Boon CJF, Banin E, Pennesi ME, Wissinger B, Webster AR, H?on E, Khan AO, Zrenner E, Michaelides M.
  • Journal Title: Am J Ophthalmol Volume: S0002-9394(21) Pages: 00117-3
  • DOI: 10.1016/j.ajo.2021.03.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term follow-up of a Chinese patient with KCNV2-retinopathy (2021)
  • Author(s): Lie H, Wang G, Liu X, Meng X, Long Y, Ren J, Yang L, Fujinami-Yokokawa Y, Kurihara T, Tsubota K, Fujinami K, Li S.
  • Journal Title: Ophthalmic Genet Volume: 42(2) Issue: 2 Pages: 144-149
  • DOI: 10.1080/13816810.2020.1861307
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spatial Functional Characteristics of East Asian Patients With Occult Macular Dystrophy (Miyake Disease); EAOMD Report No. 2 (2021)
  • Author(s): Yang L, Joo K, Tsunoda K, Kondo M, Fujinami-Yokokawa Y, Arno G, Pontikos N, Liu X, Nakamura N, Kurihara T, Tsubota K, Iwata T, Li H, Zou X, Wu S, Sun Z, Ahn SJ, Kim MS, Mun YS, Park KH, Robson AG, Miyake Y, Woo SJ, Sui R, Fujinami K; East Asia Inherited Retinal Disease Society Study Group
  • Journal Title: Am J Ophthalmol Volume: 221 Pages: 169-180
  • DOI: 10.1016/j.ajo.2020.07.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] KCNV2-Associated Retinopathy: Genetics, Electrophysiology, and Clinical Course-KCNV2 Study Group Report 1 (2020)
  • Author(s): Georgiou M, Robson AG, Fujinami K, ..., Fujinami-Yokokawa Y, et al.
  • Journal Title: Am J Ophthalmol Volume: 225 Pages: 95-107
  • DOI: 10.1016/j.ajo.2020.11.022
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RP2-associated retinal disorder in a Japanese cohort: Report of novel variants and a literature review, identifying a genotype-phenotype association. (2020)
  • Author(s): Fujinami K, Liu X, Ueno S, Mizota A, Shinoda K, Kuniyoshi K, Fujinami-Yokokawa Y, Yang L, Arno G, Pontikos N, Kameya S, Kominami T, Terasaki H, Sakuramoto H, Nakamura N, Kurihara T, Tsubota K, Miyake Y, Yoshiake K, Iwata T, Tsunoda K; Japan Eye Genetics Consortium Study Group.
  • Journal Title: Am J Med Genet C Semin Med Genet. Volume: 184 Issue: 3 Pages: 675-693
  • DOI: 10.1002/ajmg.c.31830
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and genetic characteristics of Stargardt disease in a large Western China cohort: Report 1 (2020)
  • Author(s): Liu X, Meng X, Yang L, Long Y, Fujinami-Yokokawa Y, Ren J, Kurihara T, Tsubota K, Tsunoda K, Fujinami K, Li S; East Asia Inherited Retinal Disease Society Study Group.
  • Journal Title: Am J Med Genet C Semin Med Genet Volume: 184(3) Issue: 3 Pages: 694-707
  • DOI: 10.1002/ajmg.c.31838
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and Genetic Characteristics of 15 Affected Patients From 12 Japanese Families with GUCY2D-Associated Retinal Disorder (2020)
  • Author(s): Liu X, Fujinami K, Kuniyoshi K, Kondo M, Ueno S, Hayashi T, Mochizuki K, Kameya S, Yang L, Fujinami-Yokokawa Y, Arno G, Pontikos N, Sakuramoto H, Kominami T, Terasaki H, Katagiri S, Mizobuchi K, Nakamura N, Yoshitake K, Miyake Y, Li S, Kurihara T, Tsubota K, Iwata T, Tsunoda K; Japan Eye Genetics Consortium
  • Journal Title: Transl Vis Sci Technol Volume: 11 Issue: 6 Pages: 2-2
  • DOI: 10.1167/tvst.9.6.2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and genetic characteristics of 10 Japanese patients with PROM1-associated retinal disorder: A report of the phenotype spectrum and a literature review in the Japanese population. (2020)
  • Author(s): Fujinami K, Oishi A, Yang L, Arno G, Pontikos N, Yoshitake K, Fujinami-Yokokawa Y, Liu X, Hayashi T, Katagiri S, Mizobuchi K, Mizota A, Shinoda K, Nakamura N, Kurihara T, Tsubota K, Miyake Y, Iwata T, Tsujikawa A, Tsunoda K; Japan Eye Genetics Consortium study group.
  • Journal Title: Am J Med Genet C Semin Med Genet. Volume: 184 Issue: 3 Pages: 656-674
  • DOI: 10.1002/ajmg.c.31826
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association (2020)
  • Author(s): Fujinami-Yokokawa Y, Fujinami K, Kuniyoshi K, Hayashi T, Ueno S, Mizota A, Shinoda K, Arno G, Pontikos N, Yang L, Liu X, Sakuramoto H, Katagiri S, Mizobuchi K, Kominami T, Terasaki H, Nakamura N, Kameya S, Yoshitake K, Miyake Y, Kurihara T, Tsubota K, Miyata H, Iwata T, Tsunoda K; Japan Eye Genetics Consortium.
  • Journal Title: Sci Rep Volume: 12 Issue: 1 Pages: 9531-9531
  • DOI: 10.1038/s41598-020-65737-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency. (2020)
  • Author(s): Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
  • Journal Title: Sci Rep. Volume: 10 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41598-020-62119-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phenogenon: Gene to phenotype associations for rare genetic diseases (2020)
  • Author(s): Pontikos Nikolas、Murphy Cian、Moghul Ismail、Arno Gavin、Fujinami Kaoru、Fujinami Yu、Sumodhee Dayyanah、Downes Susan、Webster Andrew、Yu Jing、UK Inherited Retinal Dystrophy Consortium, Phenopolis Consortium
  • Journal Title: PLOS ONE Volume: 15 Issue: 4 Pages: e0230587-e0230587
  • DOI: 10.1371/journal.pone.0230587
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and genetic characteristics of 14 patients from 13 Japanese families with RPGR-associated retinal disorder: report of eight novel variants. (2019)
  • Author(s): Mawatari G, Fujinami K, Liu X, Yang L, Yokokawa YF, Komori S, Ueno S, Terasaki H, Katagiri S, Hayashi T, Kuniyoshi K, Miyake Y, Tsunoda K, Yoshitake K, Iwata T, Nao-I N; JEGC study group.
  • Journal Title: Human Genome Varriation Volume: 6 Issue: 1 Pages: 34-34
  • DOI: 10.1038/s41439-019-0065-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phenotypical Characteristics of POC1B-Associated Retinopathy in Japanese Cohort: Cone Dystrophy With Normal Funduscopic Appearance (2019)
  • Author(s): Kameya Shuhei、Fujinami Kaoru、Ueno Shinji、Hayashi Takaaki、Kuniyoshi Kazuki、Ideta Ryuichi、Kikuchi Sachiko、Kubota Daiki、Yoshitake Kazutoshi、Katagiri Satoshi、Sakuramoto Hiroyuki、Kominami Taro、Terasaki Hiroko、Yang Lizhu、Fujinami-Yokokawa Yu、Liu Xiao、Arno Gavin、Pontikos Nikolas、
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 60 Issue: 10 Pages: 3432-3432
  • DOI: 10.1167/iovs.19-26650
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prediction of Causative Genes in Inherited Retinal Disorders from Spectral-Domain Optical Coherence Tomography Utilizing Deep Learning Techniques (2019)
  • Author(s): Fujinami-Yokokawa Yu、Pontikos Nikolas、Yang Lizhu、Tsunoda Kazushige、Yoshitake Kazutoshi、Iwata Takeshi、Miyata Hiroaki、Fujinami Kaoru、Japan Eye Genetics Consortium on behalf of
  • Journal Title: Journal of Ophthalmology Volume: 2019 Pages: 1-7
  • DOI: 10.1155/2019/1691064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake disease); EAOMD Report No.1 (2019)
  • Author(s): Fujinami Kaoru、Yang Lizhu、Joo Kwangsic、Tsunoda Kazushige、Kameya Shuhei、Hanazono Gen、Fujinami-Yokokawa Yu、Arno Gavin、Kondo Mineo、Nakamura Natsuko、Kurihara Toshihide、Tsubota Kazuo、Zou Xuan、Li Hui、Park Kyu Hyung、Iwata Takeshi、Miyake Yozo、Woo Se Joon、Sui Ruifang
  • Journal Title: Ophthalmology Volume: - Issue: 10 Pages: 1432-1444
  • DOI: 10.1016/j.ophtha.2019.04.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Ethnicity of pathogenic variants in the ABCA4 gene: analysis of allele frequency in the general population. (2020)
  • Author(s): Fujinami Yokokawa Y, Naka I, Pontikos N, Arno G, Yang L, Liu X, Li S, Woo SJ, Moya R, Tsunoda K, Miyata H, Ohashi J, Strauss RQ, Scholl H, Michaelides M, Fujinami K
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO) 2020 Conference
  • Int'l Joint Research
• [Presentation] Electrically Evoked Responses Elicited by Transcorneal Electrical Stimulation in Patients with Retinitis Pigmentosa. (2020)
  • Author(s): Fujinami Yokokawa Y, Suzuki Y, Yang L, Liu X, Miyata H, Farmer J, Shinoda K, Tsunoda K, Miyake Y, Fujinami K.
  • Organizer: The 58th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Full-Field Scotopic Thresholds for Color Stimuli in patients with Retinitis Pigmentosa. (2020)
  • Author(s): Suzuki Y, Yang L, Fujinami Yokokawa Y, Liu X, Farmer J, Tsunoda K, Fujinami K
  • Organizer: The 58th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Spectrum of Occult Macular Dysfunction Syndrome (OMDS): Investigation of RP1L1-positive Occult Macular Dystrophy and RP1L1-negative OMDS; EAOMD Report 5. (2020)
  • Author(s): Yang L, Joo K, Tsunoda K, Fujinami Yokokawa Y, Pontikos N, Arno G, Kondo M, Liu Z, Kurihara T, Tsubota K, Yoshitake K, Iwata T, Yamazawa K, Zuo X, Li H, Park KH, Kim MS, Mum YS, Robson AG, Miyake Y, Woo SJ, Sui R, Fujinami K
  • Organizer: The 58th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] The clinical and genetic spectrum of cone-dominated retinal dystrophies with normal funduscopic appearance (2020)
  • Author(s): Fujinami K, Ueno S, Hayashi T, Kunitoshi K, Kondo M, Mizota A, Shinoda K, Mochizuki K, Kameya S, Ideta R, Naoi N, Ikeda Y, Fujinami Yokokawa Y, et al.
  • Organizer: The 58th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Electrophysiological findings of patients with RPGR-associated retinal disorder. (2020)
  • Author(s): Nakamura N, Fujinami K, Naoi N, Ikeda Y, Hayashi T, Ueno S, Terasaki H, Kuniyoshi K, Mizota A, Shinoda K, Yang L, Fujinami Yokokawa Y, Liu X, Kominami T, Komori S, Sakuramoto H, Katagiri S, Mizobuchi K, Mawatari G, Miyake Y, Yoshitake K, Iwata K, Tsunoda K, Japan Eye Genetics Consortium study group
  • Organizer: The 58th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Oguchi disease caused by a homozygous novel SAG splicing alteration associated with the multiple evanescent white dot syndrome: A 15-month follow-up. (2020)
  • Author(s): Liu X, Gao L, Yang L, Fujinami Yokokawa Y, Wang G, Long Y, Ren J, Fujinami K, Meng X, Li S
  • Organizer: The 58th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
  • Int'l Joint Research
• [Presentation] Genotype-phenotype Association in East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.4. (2020)
  • Author(s): Fujinami Yokokawa Y, Yang L, Joo K, Tsunoda K, Kondo M, Arno G, N, Pontikos N, Liu X, Kurihara T, Tsubota K, Iwata T, Zou X, Li H, Park KH, Naka I, Ohashi J, Miyake Y, Miyata H, Woo SJ, Sui R, Fujinami K; on behalf of East Asian Inherited Retinal Disease society.
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] Spectrum of Occult Macular Dysfunction Syndrome (OMDS): Investigation of RP1L1-associated Occult Macular Dystrophy and non-RP1L1 OMDS; EAOMD Report 5. (2020)
  • Author(s): Yang L, Joo K, Liu X, Tsunoda K, Fujinami Yokokawa Y, Pontikos N, Arno G, Nakamura N, Kondo M, Kurihara T, Tsunoda K, Iwata T, Yamzawaki K, Zou X, Li H, We S, Sun Z, Ahn SJ, Kim MS, Mun YS, Park KH, Robon AG, Miyake Y, Li S, Woo SJ, Sui R, Fujinami K; EAIRDs study group.
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] Investigation of RP1L1-associated Macular Dystrophy in Southwest China. (2020)
  • Author(s): Liu X, Meng X, Yang L, Long Y, Fujinami Yokokawa Y, Ren J, Kurihara T, Tsubota K, Tsunoda K, Fujinami K, Li S; East Asia Inherited Retinal Disease Society study group.
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] Clinical and genetic characteristics of ABCA4-associated retinal disease in Japan. (2020)
  • Author(s): Fujinami K, Liu X, Mizota A, Shinoda K, Takaaki H, Kuniyoshi K, Kondo M, Ueno S, Yang L, Fujinaim-Yokokawa Y, Miyake Y, Iwata T, Tsunoda K.
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] Clinical and genetic characteristics of Stargardt disease in a large Western China cohort:report 1. (2020)
  • Author(s): Liu X, Meng H, Yang L, Long Y, Fujinami Yokokawa Y, Ren J, Kurihara T, Tsubota K, Tsunoda K, Fujinami K, Li S; East Asia Inherited Retinal Disease Society study group.
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] Genetic Spectrum of EYS-associated Retinal Disease in a Japanese Cohort: Identification of Variants with Relatively High Allele Frequency. (2020)
  • Author(s): Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] Electrophysiological Findings of Japanese Patients with RPGR-associated Retinal Disorder. (2020)
  • Author(s): Yang L, Nakamura N, Fujinami K, Naoi N, Ikeda Y, Hayashi T, Ueno S, Terasaki H, Kuniyoshi K, Mizota A, Shinota K, Fujinami Yokokawa Y, Liu X, Kominami T, Komori S, Sakurai H, Katagiri S, Mizobuchi K, Mawatari G, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] A Japanese case diagnosed with bradyopsia: clinical, electrophysiological, and genetic features. (2020)
  • Author(s): Fujinami K, Fujinami Yokokawa Y, Kondo M, Lizhu Y, Liu X, Uji Y, Iwata T, Tsunoda K
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] Clinical and genetic characteristics of USH2A-associate retinal disease in Japan. (2020)
  • Author(s): Fujinami K, Yang L, Ueno S, Kuniyoshi K, Takaaki H, Kondo M, Mizota A, Shinoda K, Naoi N, Sekiryu T, Fujinami Yokokawa Y, Liu X, Miyake Y, Iwata T, Tsunoda K; JEGC study group.
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] Ethnicity of pathogenic variants in the ABCA4 gene: analysis of allele frequency in the general population. (2020)
  • Author(s): Fujinami Yokokawa Y, Naka I, Pontikos N, Arno G, Yang L, Liu X, Li S, Woo SJ, Moya R, Tsunoda K, Miyata H, Ohashi J, Strauss RQ, Scholl H, Michaelides M, Fujinami K.
  • Organizer: The 2nd Symposium of East Asia Inherited Retinal Disease Society
  • Int'l Joint Research
• [Presentation] Spatial Functional Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake disease); EAOMD Report No.2. (2020)
  • Author(s): Yang L, Tsunoda K, Kondo M, Fujinami Yokokawa Y, Tsubota K, Iwata T, Miyake Y, Woo SJ, Sui R, Fujinami K; on behalf of East Asia Inherited Retinal Disease Society.
  • Organizer: 第68回日本視覚電気生理学会
• [Presentation] Electrophysiological characteristics of Stargardt disease in a large Western China cohort. (2020)
  • Author(s): Liu X, Meng X, Yang L, Ren J, Kurihara T, Tsubota K, Tsunoda K, Fujinami K, Li S; on behalf of East Asia Inherited Retinal Disease Society.
  • Organizer: 第68回日本視覚電気生理学会
• [Presentation] 遺伝性網膜疾患における全視野ERG を用いた自動診断支援システムの構築 (2020)
  • Author(s): 藤波（横川）優,鈴木泰賢,劉霄,楊麗珠,角田和繁,宮田裕章,藤波芳, JEGC Study Group.
  • Organizer: 第68回日本視覚電気生理学会
• [Presentation] Investigation of the origin of p.R45W causative for Occult Macular Dystrophy (Miyake’s disease) in the East Asian population (2019)
  • Author(s): Fujinami-Yokokawa Y, Naka I, Yang L, Joo K, Tsunoda K, Kondo M, Arno G, Liu X, Kurihara T, Tsubota K, Iwata T, Zou X, Li H, Park KH, Miyake Y, Pontikos N, Miyata H, Ohashi J, Woo SJ, Sui R, Fujinami K; on behalf of East Asia Inherited Retinal Disease Society.
  • Organizer: 1st EAIRDs symposium
  • Int'l Joint Research
• [Presentation] Ethnicity of pathogenic variants in the ABCA4 gene: analysis of allele frequency in the general population. (2019)
  • Author(s): Fujinami-Yokokawa Y, Naka I, Pontikos N, Arno G, Yang L, Liu X, Li Shiying, Woo SJ, Moya R, Tsunoda K, Miyata H, Ohashi J, Strauss RW, Scholl H, Michaelides M, Fujinami K.
  • Organizer: The Association for Research in Vision and Ophthalmology 2020Annual Meeting
  • Int'l Joint Research
• [Presentation] Electrically Evoked Potentials Elicited by Transcorneal Electrical Stimulation in Healthy Human Subjects; Comparison with Pattern Visual Evoked Potentials, Pattern Electroretinograms, and Photopic Negative Responses. (2019)
  • Author(s): Fujinami-Yokokawa Y, Fujinami K, Suzuki Y, Yang L, Liu X, Farmer J, Tsunoda K, Miyake Y.
  • Organizer: 57th ISCEV Symposium and Courses
  • Int'l Joint Research
• [Presentation] Prediction of Causative Genes in Inherited Retinal Disorders from Spectral-domain Optical Coherent Tomography Utilizing Deep Learning Techniques. (2019)
  • Author(s): Fujinami-Yokokawa Y, Pontikos N, Yang L, Tsunoda K, Yoshitake K, Iwata T, Miyata H, Fujinami K, Japan Eye Genetics Consortium OBO
  • Organizer: The Association for Research in Vision and Ophthalmology 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Application of Artificial Intelligence in retinal vessels on fundus photography (2019)
  • Author(s): Fujinami-Yokokawa Y
  • Organizer: The 1st retinal hemodynamics seminar
  • Int'l Joint Research / Invited
• [Presentation] Application of Artificial Intelligence in Retinal Imaging (2019)
  • Author(s): Fujinami-Yokokawa Y
  • Organizer: 1st uk-Japane retinal hemodynamics symposium
  • Int'l Joint Research / Invited
• [Presentation] Application of machine-learning for a diagnosis of inherited retinal disorders by next-generation retinal imaging (2019)
  • Author(s): Fujinami-Yokokawa Y
  • Organizer: Japanese Society of Hemorheology Annual Meeting 2019
  • Invited
• [Presentation] Genotype Phenotype Association in East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.4 (2019)
  • Author(s): Fujinami-Yokokawa Y, Yang L, Joo K, Tsunoda K, Kondo M, Arno G, Liu X, Kurihara T, Tsubota K, Iwata T, Zou X, Li H, Park KH, Naka I, Ohashi J, Miyake Y, Pontikos N, Miyata H, Woo SJ, Sui R, Fujinami K; on behalf of East Asia Inherited Retinal Disease Society
  • Organizer: 1st EAIRDs symposium
  • Int'l Joint Research
• [Presentation] Clinical and Genetic Characteristics of East Asian Patients with Stargardt disease; EAStar Report No.1. (2019)
  • Author(s): Liu X, Joo K, Fujinami-Yokokawa Y, Yin Z, Woo SJ, Li S, Fujinami K.
  • Organizer: 57th ISCEV Symposium and Courses
  • Int'l Joint Research
• [Presentation] Multimodal imaging of East Asian Patients with Occult Macular Dystrophy (Miyake’s disease): EAOMD Report No. 3. (2019)
  • Author(s): Joo K, Yang L, Kim MS, Mun YS, Tsunoda K, Kondo M, Fujinami-Yokokawa Y, Arno G, Liu X, Kurihara T, Tsubota K, Yoshitake K, Iwata T, Yamazawa K, Zou X, Li H, Robson AG, Miyake Y, Park KH, Sui R, Fujinami K, Woo SJ; on behalf of East Asia Inherited Retinal Disease Society.
  • Organizer: 57th ISCEV Symposium and Courses
  • Int'l Joint Research
• [Presentation] ke Y, Woo SJ, Sui R, Fujinami K; on behalf of East Asia Inherited Retinal Disease Society. Spectrum of Occult Macular Dystrophy: Investigation of RP1L1 Positive and RP1L1 Negative OMD; EAOMD Report No.5. (2019)
  • Author(s): Yang L, Joo K, Tsunoda K, Kondo M, Fujinami-Yokokawa Y, Arno G, Liu X, Kurihara T, Tsubota K, Yoshitake K, Iwata T, Yamazawa K, Zou X, Li H, Park KH, Kim MS, Mun YS, Robson AG, Miyake Y, Woo SJ, Sui R, Fujinami K; on behalf of East Asia Inherited Retinal Disease Society.
  • Organizer: 57th ISCEV Symposium and Courses
  • Int'l Joint Research
• [Presentation] Full-Field Pupillary Light Responses and Full-Field Scotopic Thresholds (FST) for Colour Stimuli in Healthy Human Subjects. (2019)
  • Author(s): Suzuki Y, Yang L, Fujinami-Yokokawa Y, Liu X, Suzuki M, Farmer J, Tsunoda K, Fujinami K.
  • Organizer: 57th ISCEV Symposium and Courses
  • Int'l Joint Research
• [Presentation] Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.1. (2019)
  • Author(s): Fujinami K, Yang L, Joo K, Tsunoda K, Kameya S, Hanazono G, Fujinami-Yokokawa Y, Arno G, Kondo M, Kurihara T, Tsubota K, Zou X, Li H, Park KH, Iwata T, Miyake Y, Woo SJ, Sui R; on behalf of East Asia Inherited Retinal Disease Society.
  • Organizer: 1st EAIRDs symposium
  • Int'l Joint Research
• [Presentation] Clinical and Genetic Characteristics of East Asian Patients with Stargardt disease; EAStar Report No.1. (2019)
  • Author(s): Fujinami K, Liu X, Joo K, Fujinami-Yokokawa Y, Yang L, Tsunoda K, Arno G, Pontikos N, Kurihara T, Tsubota K, Hayashi T, Ueno S, Kuniyoshi K, Shinoda K, Mizota A, Kondo M, Park KH, Ma DJ, Yu HG, Miyake Y, Iwata T, Yin Z, Woo SJ, Li J.
  • Organizer: 1st EAIRDs symposium
  • Int'l Joint Research
• [Presentation] Spectrum of Occult Macular Dystrophy: Investigation of RP1L1 Positive and RP1L1 Negative OMD; EAOMD Report No.5. (2019)
  • Author(s): Yang L, Joo K, Tsunoda K, Kondo M, Fujinami-Yokokawa Y, Arno G, Liu X, Kurihara T, Tsubota K, Yoshitake K, Iwata T, Yamazawa K, Zou X, Li H, Park KH, Kim MS, Mun YS, Robson AG, Miyake Y, Woo SJ, Sui R, Fujinami K; on behalf of East Asia Inherited Retinal Disease Society.
  • Organizer: 1st EAIRDs symposium
  • Int'l Joint Research
• [Presentation] Multimodal imaging of East Asian Patients with Occult Macular Dystrophy (Miyake’s disease): EAOMD Report No. 3. (2019)
  • Author(s): Joo K, Yang L, Tsunoda K, Kondo M, Fujinami(Yokokawa) Y, Arno G, Kurihara T, Tsubota K, Iwata T, Zou X, Li H, Park KH, Miyake Y, Fujinami K, Sui R, Woo SJ. EAIRD (East Asia Inherited Retinal) Study Groups
  • Organizer: The Association for Research in Vision and Ophthalmology 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Genotype Phenotype Association in East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.4 (2018)
  • Author(s): Yu (Yokokawa) Fujinami, Lizhu Yang, Kwangsic Joo, Kazushige Tsunoda, Mineo Kondo, Gavin Arno, Xio Liu, Kazuo Tsubota, Takeshi Iwata, Xuan Zou, Hui Li, Kyu Hyung Park, Yozo Miyake, Se Joon Woo, Ruifang Sui, Kaoru Fujinami
  • Organizer: The Association for Research in Vision and Ophthalmology Meeting
  • Int'l Joint Research
• [Presentation] Genotype Phenotype Association in East Asian Patients with Occult Macular Dystrophy (Miyake’s disease); EAOMD Report No.4 (2018)
  • Author(s): Yu (Yokokawa) Fujinami, Lizhu Yang, Kwangsic Joo, Kazushige Tsunoda, Mineo Kondo, Gavin Arno, Xio Liu, Kazuo Tsubota, Takeshi Iwata, Xuan Zou, Hui Li, Kyu Hyung Park, Yozo Miyake, Se Joon Woo, Ruifang Sui, Kaoru Fujinami
  • Organizer: International Society for Clinical Electrophysiology of Vision
  • Int'l Joint Research
• [Book] 眼科診療ビジュアルラーニング5網膜，硝子体 (2020)
  • Author(s): 藤波 芳, 藤波 優, 鈴木 泰賢
  • Total Pages: 5
  • Publisher: 株式会社中山書店
• [Book] Stargardt disease in Asian population. Advances in Vision Research, Volume II. (2019)
  • Author(s): Liu X, Fujinami (Yokokawa) Y, Yang L, Arno G, Fujinami K
  • Total Pages: 17
  • Publisher: Springer
• [Book] 診療で役立つ！ 近視進行予防のサイエンス３章(１) (2019)
  • Author(s): 藤波芳、姜効炎、楊麗珠、劉霄、藤波（横川）優.
  • Total Pages: 5
  • Publisher: 金原出版
  • ISBN: 9784307351713