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Control of ocular surface diseases focusing on endogenous lipid mediators

Research Project

Project/Area Number 18K16966
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56060:Ophthalmology-related
Research InstitutionJuntendo University

Principal Investigator

Iwamoto Satoshi  順天堂大学, 医学部, 助教 (10568207)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords角膜創傷治癒 / 脂質メディエーター / BLT2 / 12-HHT / 12HHT / BLT2受容体 / レゾルビン / アレルギー性結膜炎
Outline of Final Research Achievements

We have studied the effects of 12-HHT, an endogenous lipid mediator, on the ocular surface.
BLT2, a receptor for 12-HHT, is expressed in the cornea and conjunctiva, and corneal wound healing is delayed in BLT2 receptor-knockout mice. Also, as a clinical study, we tried to quantify 12-HHT contained in human tear fluid. However, the amount of 12-HHT from normal human tear fluid varied greatly due to the time required for measurement and individual differences, and high-precision quantification was not possible. In the future, we plan to try again to quantify lipids from human tears while improving the quality of lipid quantification.

Academic Significance and Societal Importance of the Research Achievements

我々は日常の臨床で遷延性角膜上皮欠損の患者に遭遇する。しかしながら、点眼による治療で改善に乏しいこともあり、治療い難渋するケースがある。我々の研究は角膜上皮の創傷治癒に対する新規治療薬を目標として研究を続けており、今までにあまり注目されていなかった脂質メディエーターが角膜創傷治癒に及ぼす影響を研究している。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018

All Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Funded Workshop (1 results)

  • [Presentation] 12HHT/BLT2経路を介した角膜創傷治癒促進の分子メカニズムの解析2020

    • Author(s)
      岩本怜
    • Organizer
      第124回日本眼科学会総会
    • Related Report
      2020 Research-status Report 2019 Research-status Report
  • [Presentation] Ocular surfaceと非ステロイド性抗炎症薬2019

    • Author(s)
      岩本怜
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Expression of nicotinamide N-methyltransferase (NNMT) in atopic cataract2019

    • Author(s)
      Satoshi Iwamoto
    • Organizer
      Association for Research in Vision and Ophthalmology(ARVO)
    • Related Report
      2019 Research-status Report
  • [Presentation] Control of mouse allergic conjunctivitis by resolvins2018

    • Author(s)
      Satoshi Iwamoto
    • Organizer
      ARVO
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] レゾルビンによるマウスアレルギー性結膜炎の制御2018

    • Author(s)
      岩本怜
    • Organizer
      第122回日本眼科学会総会
    • Related Report
      2018 Research-status Report
  • [Funded Workshop] Association for Research in Vision and Ophthalmology(ARVO)2019

    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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