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Rewiring of neural circuits following peripheral nerve transfers

Research Project

Project/Area Number 18K16981
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56070:Plastic and reconstructive surgery-related
Research InstitutionNiigata University

Principal Investigator

Wakatsuki Hanako  新潟大学, 医歯学総合病院, 特任助教 (20749642)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords再生医学 / 再建外科学
Outline of Final Research Achievements

Nerve transfers have provided good clinical outcomes, the anatomical and molecular mechanisms that underlie this regenerative process remain unknown. I have demonstrated that neurons in new neural circuits are excited after nerve transfer by using a mouse nerve-transfer model for brachial plexus injury. This observation demonstrated that a different dominant spinal segment is excited through a new neural circuit.

Academic Significance and Societal Importance of the Research Achievements

神経回路再編の機序や再生軸索の発芽や分枝を制御する機構、神経損傷後に起こるシナプスの消退と再生後の再接続の機構などを解明することを目的とし、マウス腕神経叢モデルで神経移行術後の組織学的検討を行ってきた。神経縫合術、神経移行術を行った群で、神経縫合部より近位で電気刺激を行い、神経縫合術および神経移行術後に神経回路標識で標識された前角細胞と後根神経節細胞でのc-Fos(ニューロンでの刺激に応答して一時的に発現する)の発現を観察し、あらたな神経回路を通して別の支配髄節が興奮していることを証明した。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2018

All Presentation (3 results)

  • [Presentation] 末梢神経移行術後の神経回路再編2018

    • Author(s)
      若槻華子、親松宏、柴田実、松田健、佐藤昇
    • Organizer
      第45回日本マイクロサージャリー学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 末梢神経移行術後の神経回路再編2018

    • Author(s)
      若槻華子、親松宏、柴田実、松田健、佐藤昇
    • Organizer
      第27回日本形成外科学会基礎学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 末梢神経移行術後の神経回路再編2018

    • Author(s)
      若槻華子、渡辺啓介、千葉映奈、柴田実、松田健、佐藤昇
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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