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Development of a new antithrombogenic coating material based on star polymer for a small diameter artificial blood vessel

Research Project

Project/Area Number 18K16990
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56070:Plastic and reconstructive surgery-related
Research InstitutionKyushu University

Principal Investigator

TOTANI MASAYAUS  九州大学, 工学研究院, 特任助教 (20773500)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords高分子界面 / 精密重合 / 多分岐高分子 / 星型高分子 / 生体適合性 / 防汚特性 / 抗血栓性材料 / 細胞接着抑制 / 小口径人工血管 / 星型ポリマー / 水和層 / 生体適合性材料 / 血液適合性材料 / 血小板粘着抑制 / 星形ポリマー
Outline of Final Research Achievements

A star-like hyperbranched polymer having hydrophilic poly(ethyleneoxide acrylate) arms (HB-PEO9A) was prepared by a core-first method based on atom transfer radical polymerization. The PEO9A layer coated on a solid substrate was dissolved by water, and effectively inhibited protein adsorption and cell adhesion.
To clear the bioinert property on water-interface, a novel photo-crosslinkable hyperbranched polymer having multi-benzophenone groups (HB-BP) was synthesized. This system was used to photograft the water-soluble and bioinert bottle-brush polymer, poly(ethylene oxide methacrylate) with 9 ethylene oxide units (PEO9MA) and its derivatives on HB-BP coating layer. The physical surface properties of PEO9MA derivatives on HB-BP indicated different elastic modulus values and defused polymer interface with water depend on PEO side-chain density, and controlled NIH3T3 fibroblasts attachment.

Academic Significance and Societal Importance of the Research Achievements

本申請課題では、高密度親水性ポリエチレンオキシド鎖を有する星型多分岐高分子(HB-PEO9A)を精密重合法により合成した。このHB-PEO9A膜のタンパク質吸着試験、血小板粘着試験、細胞接着試験を行った結果、優れたバイオイナート特性を示すことが明らかとなった。この高密度ポリエチレンオキシド鎖を導入した星型多分岐高分子は、これまでに開発してきたポリヒドロキシエチルメタクリレート(PHEMA)鎖を有する星型多分岐高分子に比べ高い血小板粘着抑制、細胞接着抑制を示した。PET基板表面上において高い接着性を有する星型多分岐高分子膜が得られたことから被覆材料として応用可能であることが明らかとなった。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (21 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (17 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A Dynamic Interface Based on Segregation of an Amphiphilic Hyperbranched Polymer Containing Fluoroalkyl and Oligo(ethylene oxide) Moieties2020

    • Author(s)
      Yukari Oda, Manabu Inutsuka, Ryo Awane, Masayasu Totani, Norifumi L. Yamada, Masayuki Haraguchi, Masaaki Ozawa, Hisao Matsuno, and Keiji Tanaka
    • Journal Title

      Macromolecules

      Volume: 53 Issue: 7 Pages: 2380-2387

    • DOI

      10.1021/acs.macromol.9b02064

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of a star-like hyperbranched polymer having hydrophilic arms for anti-biofouling coating2019

    • Author(s)
      Masayasu Totani, Ling Liu, Hisao Matsuno, Keiji Tanaka
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 7 Issue: 7 Pages: 1045-1049

    • DOI

      10.1039/c8tb03104e

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Water-induced Surface Reorganization of Bioscaffolds Composed of an Amphiphilic Hyperbranched Polymer2019

    • Author(s)
      Hisao Matsuno, Masayasu Totani, Arisa Yamamoto, Masayuki Haraguchi, Masaaki Ozawa, Keiji Tanaka
    • Journal Title

      Polym. J.

      Volume: 51 Issue: 10 Pages: 1045-1053

    • DOI

      10.1038/s41428-019-0212-5

    • NAID

      40022176701

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bioinert Properties of Epoxy/Betaine Based Polymer Adhesive2020

    • Author(s)
      Masayasu Totani, Junko Katayama, Masaaki Ozawa, Nobutomo Tsuruzoe, Hisao Matsuno and Keiji Tanaka
    • Organizer
      第68回高分子学会年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 光架橋性官能基を導入した生体適合性接着剤の分子設計と機能2020

    • Author(s)
      戸谷匡康、片山淳子、小澤雅昭、水流添暢智、松野寿生、田中敬二
    • Organizer
      第58回日本接着学会年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Aggregation States of Bio-inert Interface Using Photo-Cross-Linkable Hyperbranched Polymer2019

    • Author(s)
      Ling Liu, Masayasu Totani, Hisao Matsuno, Keiji Tanaka
    • Organizer
      第68回高分子学会年次大
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生体成分の接着を制御した界面の構築2019

    • Author(s)
      戸谷 匡康、 Ling Liu、松野寿生、田中敬二
    • Organizer
      第57回 日本接着学会 年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Design of a Photo-crosslinkable Bioinert Coating Based on a Hyperbranched Polymer2019

    • Author(s)
      Ling Liu, Masayasu Totani, Hisao Matsuno, Keiji Tanaka
    • Organizer
      第57回 日本接着学会 年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Control of Cellular Behaviors on Bottle-brush Copolymers Grafted to Hyperbranched Polymers2019

    • Author(s)
      Ling Liu, Masayasu Totani, Hisao Matsuno, Keiji Tanaka
    • Organizer
      Tentative Schedule of 2019 Japan-Taiwan Bilateral Polymer Symposium (JTBPS2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Control of Fibroblast Adhesion Based on Mechanical Properties of Bottle-brush Polymers at Water Interface2019

    • Author(s)
      Ling Liu, Masayasu Totani, Hisao Matsuno, Keiji Tanaka
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生体成分の接着を制御した多分岐高分子界面の構築2019

    • Author(s)
      戸谷 匡康、 Ling Liu、松野寿生、田中敬二
    • Organizer
      第18回高分子表面研究討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] エポキシ/ベタイン含有生体適合性接着剤の力学特性2019

    • Author(s)
      戸谷匡康、片山淳子、小澤雅昭、水流添暢智、松野寿生、田中敬二
    • Organizer
      高分子若手研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] エポキシ/ベタインを含有した生体適合性接着剤の構築2019

    • Author(s)
      戸谷匡康、片山淳子、小澤雅昭、水流添暢智、松野寿生、田中敬二
    • Organizer
      繊維学会秋季研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Aggregation States of Bio-inert Interface Using a Photo-Cross-Linkable Hyperbranched Polymer2019

    • Author(s)
      Ling Liu, Masayasu Totani, Hisao Matsuno, Keiji Tanaka
    • Organizer
      第68回 高分子学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Design of a Photo-crosslinkable Bioinert Coating Based on a Hyperbranched Polymer2019

    • Author(s)
      Ling Liu, Masayasu Totani, Hisao Matsuno, Keiji Tanaka
    • Organizer
      第57回日本接着学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 生体成分の接着を制御した界面の構築2019

    • Author(s)
      戸谷 匡康,Ling Liu,松野 寿生,田中 敬二
    • Organizer
      第57回日本接着学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 星型多分岐高分子を応用した 生体適合性界面の構築2018

    • Author(s)
      戸谷匡康、原口将幸、松野寿生、水流添暢智、田中敬二
    • Organizer
      九州地区高分子若手研究会・夏の後援会
    • Related Report
      2018 Research-status Report
  • [Presentation] 星型多分岐高分子を応用した生体適合性界面の構築2018

    • Author(s)
      戸谷匡康、原口将幸、松野寿生、水流添暢智、田中敬二
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 防汚性コート材料のための親水性鎖を有する多分岐高分子の設計2018

    • Author(s)
      戸谷匡康、松野寿生、田中敬二
    • Organizer
      平成30年度 九州支部高分子若手研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] BiomertCoatingUsingaPhotocrosslinkableHyperbranchedPolymer2018

    • Author(s)
      Ling Liu, Masayasu Totani, Hisao Matsuno, Keiji Tanaka
    • Organizer
      平成30年度 九州支部高分子若手研究会・冬の後援会
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] 生体適合性接着剤2019

    • Inventor(s)
      戸谷匡康、片山淳子、小澤雅昭、水流添暢智、松野寿生、田中敬二
    • Industrial Property Rights Holder
      戸谷匡康、片山淳子、小澤雅昭、水流添暢智、松野寿生、田中敬二
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-194425
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2021-02-19  

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