| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The cellularized, elastic, biocomposite scaffold (Extracellular matrix: ECM + Poly(ester-urethane) Ureas: PEUU) was transplanted to the thigh of rat to evaluate the ability of tissue regeneration. The expressions of RNA related with nerve regeneration had no significant differences among the experimental group, negative and positive control groups. The nerve elongation into the transplanted materials were observed in the immunohistochemistrial samples. Muscle regeneration were also observed and the strength of regenerated muscle was recovered stronger than preoperative values. The material used in this experimental study should be one of the effective treatment for refractory ulcers represented by diabetic skin ulcers.
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