Regulation of sensory nerve system in lymphangigenesis and lymph edema
Project/Area Number |
18K16994
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
|
Research Institution | Kitasato University |
Principal Investigator |
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | リンパ浮腫 / 神経ペプチド / リンパ管新生 / CGRP / RAMP1 / リンパ管 / マクロファージ / リンパ / 知覚神経 |
Outline of Final Research Achievements |
Secondary lymphedema commonly arises as a complication of cancer surgery and radiation treatment; however, the underlying mechanisms are poorly understood. The present study examined whether RAMP1 plays a role in increased lymphangiogenesis during secondary lymphedema. A model of lymphedema was generated by surgical removal of pre-existing lymphatic vessels from the subcutaneous tissue on the tails of RAMP1-deficient (RAMP1-/-) mice and their wild-type (WT) counterparts. Lymphedema in RAMP1-/- mice was sustained, with suppressed lymphangiogenesis and reduced expression of vascular endothelial growth factor (VEGF)-C and VEGFR-3. The number of pro-inflammatory macrophages in RAMP1-/- mice was higher than that in WT mice. RAMP1 signaling improves lymphedema and accelerates lymphangiogenesis associated with reduced recruitment of pro-inflammatory macrophages.
|
Academic Significance and Societal Importance of the Research Achievements |
乳がんの腋窩リンパ節廓清術後、子宮・卵巣がんの骨盤内リンパ節廓清術後、またこれらに追加される放射線療法後などの患者では2次性のリンパ浮腫が発症することがある。多くは難治性で慢性化するだけでなく、皮膚の広範な肥厚と線維化、繰り返す蜂窩織炎などのために患者のQOLは著しく損なわれる。現在でも本質的な治療方法はないため、リンパ再生を含めたリンパ管新生増強方策が切望されている。この点、CGRPや特異的RAMP1アゴニストが2次性リンパ浮腫の治療に有効であることが期待される。
|
Report
(4 results)
Research Products
(6 results)
-
-
-
-
-
[Journal Article] Cerebral oximetry for cardiac surgery: a preoperative comparison of device characteristics and pitfalls in interpretation2018
Author(s)
Kobayashi K, Kitamura T, Kohira S, Torii S, Mishima T, Ohkubo H, Tanaka Y, Sasahara A, Fukunishi T, Ohtomo Y, Horikoshi R, Murai Y, Miyaji K
-
Journal Title
J Artif Organs
Volume: 21
Issue: 4
Pages: 412-418
DOI
Related Report
Open Access
-