| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The aim of this study was to elucidate the antibacterial and anti-inflammatory activities of a component of cinnamon, and to contribute to the development of a new therapeutic agent for periodontal disease.
The antibacterial activity against typical periodontopathic bacteria was clarified. In addition, a component of cinnamon showed anti-inflammatory activity against the production of inflammatory cytokines induced by LPS stimulation from periodontopathic bacteria. Furthermore, the inhibitory effect on alveolar bone resorption was demonstrated using a mouse model of periodontal disease.
These results suggest the possibility of applying a component of cinnamon as a novel periodontal drug.
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