| Project/Area Number |
18K17047
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Osaka University |
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Principal Investigator |
Matsuda Yusuke 大阪大学, 歯学部附属病院, 医員 (40808507)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 糖化 / 象牙質 / 加齢 / 老化 / コラーゲン / 糖化最終産物 / う蝕 / 架橋 / pentosidine |
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| Outline of Final Research Achievements |
AGEs accumulate in dentin during caries. AGEs accumulate along the dentin tubules from the enamel-dentin interface to the pulp, and in caries-affected dentin. The accumulation of AGEs occurs with age in healthy area, otherwise is increased and affected by dentinal caries in caries area. In particular, pentosidine, one of the cross-linked AGEs, was found to be significantly increased in caries affected and infected dentin. The shortening of the fluorescence lifetime in the caries-affected area suggests that AGEs with a shorter fluorescence lifetime than that of the surrounding substrate are increased by caries.
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| Academic Significance and Societal Importance of the Research Achievements |
基質への糖化最終産物の蓄積は、う蝕罹患部位において増加することが分かった。これにより蛍光寿命は物質に特有の値を示し、コラーゲンよりも蛍光寿命の短いAGEsの沈着によって蛍光寿命は短くなる。AGEsの沈着部位と齲蝕の進行部位に関連性が見られることからAGEsの沈着を見ることで齲蝕の進行の一つのマーカーとして利用できるのではないかと考えられる。AGEsの蛍光寿命を用いる方法は、象牙質コラーゲンの質的要素を見ているため、入射光の強度や試料の表面性状に依存しない。齲蝕の除去指標の１つとして利用できるのではないかと考えられる。
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