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Nano and micro-structured biomaterials for bone regeneration

Research Project

Project/Area Number 18K17061
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

IKAWA TAKAHIRO  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (20780290)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体材料 / 骨補填材 / 歯周病 / インプラント / 歯周組織再生 / 成長因子 / インプラント周囲炎 / 細胞増殖因子 / 抗菌作用 / 再生治療 / 組織工学
Outline of Final Research Achievements

Bone grafted materials are indispensable for periodontal regeneration tissue and treatment. In anticipation of complete replacement with bone, it is required that a new perspective of a bone grafting material that utilizes the factors involved in regeneration.
In this study, it was researched that bone replacement time by adjusting the structure of the biomaterial. New bone formation was observed in the long-term (6months) using bone grafting material with a macrostructure (pore size of 300 μm). It was observed that an additional bone formation on the implant surface using biomaterials(Anorganic bovine bone) combined with a growth factor (enamel matrix derivative).

Academic Significance and Societal Importance of the Research Achievements

本研究課題にて、ミクロ・マクロ構造を検討することで従来の顆粒と比較して骨への置換時期の違いが起こることが示唆された。これにより術後感染や再生阻害の原因しない骨補填材の改良への応用が期待される。また成長因子を併用することで、インプラント表面の骨形成に有効なことが示唆された。つまり、治癒期間が短縮されることで、より低侵襲な外科手術あるいは局所の炎症を抑えることが可能となり、高齢者を含めた患者のQOLを高めることに大きく貢献すると考えられる。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Book (5 results)

  • [Journal Article] Clinical comparison of an electric‐powered ionic toothbrush and a manual toothbrush in plaque reduction: A randomized clinical trial2020

    • Author(s)
      Ikawa Takahiro、Mizutani Koji、Sudo Takeaki、Kano Chihiro、Ikeda Yuichi、Akizuki Tatsuya、Kobayashi Hiroaki、Izumi Yuichi、Iwata Takanori
    • Journal Title

      International Journal of Dental Hygiene

      Volume: 19 Issue: 1 Pages: 93-98

    • DOI

      10.1111/idh.12475

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accuracy of cone beam computed tomography in evaluation of palatal mucosa thickness.2020

    • Author(s)
      Ogawa M, Katagiri S, Koyanagi T, Maekawa S, Shiba T, Ohsugi Y, Takeuchi Y, Ikawa T, Takeuchi S, Sekiuchi T, Arai Y, Kazama R, Wakabayashi N, Izumi Y, Iwata T.
    • Journal Title

      J Clin Periodontol.

      Volume: 4 Issue: 4 Pages: 479-488

    • DOI

      10.1111/jcpe.13254

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enamel matrix derivative in liquid form as adjunct to natural bovine bone grafting at buccal bone dehiscence defects at implant sites: An experimental study in beagle dogs.2019

    • Author(s)
      Ikawa T, Akizuki T, Shujaa Addin A, Fukuba S, Stavropoulos A, Izumi Y.
    • Journal Title

      Clin Oral Implants Res.

      Volume: 10 Issue: 10 Pages: 989-996

    • DOI

      10.1111/clr.13512

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Effect of natural bovine bone with and without EMD liquid (Osteogain) on implants with buccal bone defects- an experimental study in beagle dogs2019

    • Author(s)
      Ikawa Takahiro, Tatsuya Akizuki, Ammar Shujaa Addin, FUKUBA Shunsuke, Stavropoulos Andreas, Izumi Yuichi.
    • Organizer
      European Association for Osseointegration
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] T字型歯ブラシ(T‐STYLE)を用いた歯垢除去に対する臨床評価2018

    • Author(s)
      岩渕義之, 井川貴博, 鈴木彩, 加納千博, 須藤毅顕, 池田裕一, 水谷幸嗣, 和泉雄一
    • Organizer
      日本歯科保存学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 歯科用エックス線CT装置(CBCT)を応用した口蓋粘膜厚径の計測2018

    • Author(s)
      小川実穂, 片桐さやか, 竹内康雄, 小柳達郎, 井川貴博, 竹内祥吾, 関内孝侑, 新井祐貴, 風間龍之介, 若林則幸, 和泉雄一
    • Organizer
      日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高密度植毛歯ブラシを用いたプラーク除去効果の検討2018

    • Author(s)
      平井亮, 井川貴博, 加納千博, 吉田直晃, 大津杏理, 池田裕一, 水谷幸嗣, 和泉雄一
    • Organizer
      日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] The effect of electric-powered ionic toothbrushing on plaque removal randomized clinical trial2018

    • Author(s)
      Kano C, Mizutani K, Ikawa T, Sudo T, Kobayashi H, Izumi Y.
    • Organizer
      Europerio9
    • Related Report
      2018 Research-status Report
  • [Book] PRD YEARBOOK 20202020

    • Author(s)
      岩田健男、山﨑長郎、和泉雄一
    • Total Pages
      184
    • Publisher
      クインテッセンス出版
    • ISBN
      4781207650
    • Related Report
      2020 Research-status Report
  • [Book] 高齢者に対する歯周治療2018

    • Author(s)
      和泉雄一, 井川貴博, 大津杏理
    • Total Pages
      906
    • Publisher
      日本歯科評論
    • Related Report
      2018 Research-status Report
  • [Book] 口腔外科ハンドマニュアル'182018

    • Author(s)
      井川貴博, 秋月達也, 和泉雄一
    • Total Pages
      216
    • Publisher
      クインテッセンス出版
    • Related Report
      2018 Research-status Report
  • [Book] 非外科治療による歯周病コントロール2018

    • Author(s)
      Jr.,Paul A. Levi (著), Robert J. Rudy (著), Y.Natalie Jeong (著), Daniel K. Coleman (著), 和泉 雄一 (翻訳), 木下 淳博 (翻訳), 長澤 敏行 (翻訳), 青木 章 (翻訳).
    • Total Pages
      240
    • Publisher
      医歯薬出版
    • Related Report
      2018 Research-status Report
  • [Book] 歯科衛生士の力でここまでできる 非外科的歯周治療2018

    • Author(s)
      Marisa Roncati (著), 和泉 雄一 (監修, 翻訳)
    • Total Pages
      352
    • Publisher
      クインテッセンス社
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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