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Development of innovative highly performance dental cement for root carues

Research Project

Project/Area Number 18K17068
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionNational Institute of Advanced Industrial Science and Technology (2019)
Okayama University (2018)

Principal Investigator

Yoshihara Kumiko  国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (90631581)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords根面う蝕 / グラスアイオノマーセメント / 修復材料 / ポリマー / 接着強さ / 歯質接着 / 界面 / 化学分析
Outline of Final Research Achievements

Recently, many elders has root caries, root caries lesions often are close to the gingival margin. It is often difficult for root caries to treat using general adhesive and composite resin treatment because of difficulty of moisture control. In this case, glass ionomer cements (GIC) are often used, however the mechanical property and adhesiveness on tooth of GIC are not sufficient. In this research, as a synthesis of a new high-performance polymer, we synthesized novel high-performance polymers such as polyvinyl alcohol with several functional groups. Then we applied these polymers for conventional GIC in order to improve mechanical properties and dentin adhesion. Some syntheses polymer could improve mechanical property and bond strength on dentin. This data revealed incorporating novel polymer into GIC liquid may useful.

Academic Significance and Societal Importance of the Research Achievements

根面う蝕を持つ高齢者が増加している。コンポジットレジンでの修復が難しい場合にはグラスアイオノマーセメントが用いられるが、強度などが十分でなく新たな根面う蝕用材料が望まれている。新規ポリマーの添加により、歯質接着性、機械的性質を向上させることができた。本研究により、グラスアイオノマーセメントのポリマー成分の改良によって,機械的特性,接着性を向上させることができることが示唆された。根面う蝕用の治療材料として実用化できる可能性を持っている。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (31 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 13 results,  Open Access: 2 results) Presentation (17 results) (of which Int'l Joint Research: 7 results)

  • [Int'l Joint Research] KULeuven(ベルギー)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Injectable phosphopullulan-functionalized calcium-silicate cement for pulp-tissue engineering: An in-vivo and ex-vivo study2020

    • Author(s)
      Pedano MS, Li X, Camargo B, Hauben E, De Vleeschauwer S, Yoshihara K, Van Landuyt K, Yoshida Y, Van Meerbeek B
    • Journal Title

      Dental Materials

      Volume: 36 Issue: 4 Pages: 512-526

    • DOI

      10.1016/j.dental.2020.01.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Three-dimensional observation and analysis of remineralization in dentinal caries lesions2020

    • Author(s)
      Yoshihara Kumiko、Nagaoka Noriyuki、Nakamura Akiko、Hara Toru、Hayakawa Satoshi、Yoshida Yasuhiro、Van Meerbeek Bart
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41598-020-61111-1

    • NAID

      120006884920

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] From Buonocore's Pioneering Acid-Etch Technique to Self-Adhering Restoratives. A Status Perspective of Rapidly Advancing Dental Adhesive Technology2020

    • Author(s)
      Van Meerbeek B, Yoshihara K, Van Landuyt K, Yoshida Y, Peumans M
    • Journal Title

      Journal of Adhesive Dentistry

      Volume: 22 Pages: 7-34

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ultrastructure and bonding properties of tribochemical silica-coated zirconia2019

    • Author(s)
      Nagaoka N, Yoshihara K, Tamada Y, Yoshida Y, Van Meerbeek B
    • Journal Title

      Dental Materials Journal

      Volume: 38 Issue: 1 Pages: 107-113

    • DOI

      10.4012/dmj.2017-397

    • NAID

      130007592218

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2019-01-28
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quick bonding using a universal adhesive2019

    • Author(s)
      Ahmed MH, Yoshihara K, Mercelis B, Van Landuyt K, Peumans M, Van Meerbeek B
    • Journal Title

      Clin Oral Investig

      Volume: 2019 Dec 7 Issue: 8 Pages: 2837-2851

    • DOI

      10.1007/s00784-019-03149-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite2019

    • Author(s)
      Matsuo Kenya、Yoshihara Kumiko、Nagaoka Noriyuki、Makita Yoji、Obika Hideki、Okihara Takumi、Matsukawa Akihiro、Yoshida Yasuhiro、Van Meerbeek Bart
    • Journal Title

      Acta Biomaterialia

      Volume: 100 Pages: 388-397

    • DOI

      10.1016/j.actbio.2019.09.045

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Atomic level observation and structural analysis of phosphoric-acid ester interaction at dentin2019

    • Author(s)
      Yoshihara Kumiko、Nagaoka Noriyuki、Yoshida Yasuhiro、Van Meerbeek Bart、Hayakawa Satoshi
    • Journal Title

      Acta Biomaterialia

      Volume: 97 Pages: 544-556

    • DOI

      10.1016/j.actbio.2019.08.029

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bonding to enamel using alternative Enamel Conditioner/etchants2019

    • Author(s)
      Yao Chenmin、Ahmed Mohammed H.、Yoshihara Kumiko、Mercelis Ben、Parise Gre Cristina、Van Landuyt Kirsten L.、Huang Cui、Van Meerbeek Bart
    • Journal Title

      Dental Materials

      Volume: 35 Issue: 10 Pages: 1415-1429

    • DOI

      10.1016/j.dental.2019.07.022

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Survival of human dental pulp cells after 4-week culture in human tooth model2019

    • Author(s)
      Pedano Mariano S.、Li Xin、Jeanneau Charlotte、Ghosh Manosij、Yoshihara Kumiko、Van Landuyt Kirsten、About Imad、Van Meerbeek Bart
    • Journal Title

      Journal of Dentistry

      Volume: 86 Pages: 33-40

    • DOI

      10.1016/j.jdent.2019.05.023

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Do Universal Adhesives Benefit from an Extra Bonding Layer?2019

    • Author(s)
      Ahmed MH, De Munck J, Van Landuyt K, Peumans M, Yoshihara K, Van Meerbeek B.
    • Journal Title

      Journal of Adhesive Dentistry

      Volume: 21 Pages: 117-132

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Freshly-mixed and setting calcium-silicate cements stimulate human dental pulp cells2018

    • Author(s)
      Pedano M, Li X, Li S, Sun Z, Cokic S, Putzeys E, Yoshihara K, Yoshida Y, Chen Z, Van Landuyt K, Van Meerbeek B
    • Journal Title

      Dental Materials

      Volume: 印刷中 Issue: 5 Pages: 1-12

    • DOI

      10.1016/j.dental.2018.02.005

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Etching Efficacy of Self-Etching Functional Monomers2018

    • Author(s)
      Yoshihara K.、Hayakawa S.、Nagaoka N.、Okihara T.、Yoshida Y.、Van Meerbeek B.
    • Journal Title

      Journal of Dental Research

      Volume: 印刷中 Issue: 9 Pages: 1-7

    • DOI

      10.1177/0022034518763606

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemical interaction of glycero-phosphate dimethacrylate (GPDM) with hydroxyapatite and dentin2018

    • Author(s)
      Yoshihara Kumiko、Nagaoka Noriyuki、Hayakawa Satoshi、Okihara Takumi、Yoshida Yasuhiro、Van Meerbeek Bart
    • Journal Title

      Dental Materials

      Volume: 印刷中 Issue: 7 Pages: 1072-1081

    • DOI

      10.1016/j.dental.2018.04.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Development of self-adhesive pulp-capping agents containing functional monomer2020

    • Author(s)
      Yoshihara K, Nagaoka N, Maruo Y, Yoshida Y, Van Meerbeek B
    • Organizer
      The 2020 IADR/AADR/CADR General Session & Exhibition,
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bacterial related to Root Caries; What is the cause?2020

    • Author(s)
      Yoshihara K
    • Organizer
      The 2020 IADR/AADR/CADR General Session & Exhibition,
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リン酸化ポリビニルアルコールのグラスアイオノマーセメントへの応用2019

    • Author(s)
      吉原久美子、長岡紀幸、吉田靖弘
    • Organizer
      第151回日本歯科保存学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 液体アクリルアミド系モノマー含有接着材の検討2019

    • Author(s)
      吉原久美子、長岡紀幸、吉田靖弘
    • Organizer
      第73回歯科理工学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of alkalic hydraulic calcium-silicate cement on the covering material2019

    • Author(s)
      Yoshihara K, Nagaoka N, Ogawa T, Yoshida Y, Van Meerbeek B.
    • Organizer
      The 2019 IADR/AADR/CADR General Session & Exhibition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The silane-coupling effect of a silane-containing self-adhesive composite cement,2019

    • Author(s)
      Yoshihara K, Nagaoka N, Yoshida Y, Van Meerbeek B.
    • Organizer
      International Congress on Adhesive Dentstry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ユニバーサルボンディング材のⅠ級窩洞における象牙質接着強さ2019

    • Author(s)
      吉原久美子、長岡紀幸、吉田靖弘
    • Organizer
      第128回保存歯科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新規シランカップリング剤添加型レジンセメントのシランカップリング2019

    • Author(s)
      吉原久美子、長岡紀幸、吉田靖弘
    • Organizer
      歯科補綴学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 化学重合型マルチプライマーの歯質接着界面の解析2019

    • Author(s)
      吉原久美子、長岡紀幸、吉田靖弘
    • Organizer
      歯科理工学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] プライマー接触硬化型レジンセメント重合のリアルタイム測定2018

    • Author(s)
      吉原久美子、長岡紀幸、吉田靖弘
    • Organizer
      第71回日本歯科理工学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] Chemical interaction of a novel functional monomer with zirconia Bond durability of a novel fluoro-carbon functional monomer with zirconia.2018

    • Author(s)
      YOSHIHARA K, Hayakawa S, Nagaoka N, Yoshida Y, Van Meerbeek B.
    • Organizer
      IADR/PER General Session. London, UK.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Atomic level structural analysis of 10-MDP-Ca salts in adhesive-dentin interface.2018

    • Author(s)
      YOSHIHARA K, Hayakawa S, Nagaoka N, Yoshida Y, Van Meerbeek B.
    • Organizer
      IADR/PER General Session. London, UK.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional Observation And Mechanical Property Analysis Of Self-assembled Nano-layering.2018

    • Author(s)
      YOSHIHARA K, Nagaoka N, Hara T, Nakamura A, Yoshida Y, Van Meerbeek B.
    • Organizer
      IADR/PER General Session. London, UK.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ワンステップ接着システムにおける歯質界面の生成物と物性の関係2018

    • Author(s)
      鈴木一臣、長岡紀幸、吉原久美子、松本卓也、吉田靖弘
    • Organizer
      第72回日本歯科理工学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 化学重合型マルチプライマーの歯質接着界面の解析2018

    • Author(s)
      吉原久美子、長岡紀幸、吉田靖弘
    • Organizer
      第72回日本歯科理工学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新規抗菌材添加セメントのバイオフィルム形成抑制特性2018

    • Author(s)
      吉原久美子、長岡紀幸、槇田洋二、山本裕也、吉田靖弘
    • Organizer
      平成30年度秋季大会日本歯科保存学会
    • Related Report
      2018 Research-status Report
  • [Presentation] モノマーカルシウム塩の層状構造の三次元観察と接着界面の弾性率評価2018

    • Author(s)
      吉原久美子、長岡紀幸、吉田靖弘
    • Organizer
      第37回日本接着歯学会学術大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2021-02-19  

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