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Elucidation of the mechanisms of PHT and NIF induced gingival overgrowth

Research Project

Project/Area Number 18K17070
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionHiroshima University

Principal Investigator

OKANOBU AI  広島大学, 医系科学研究科(歯), 助教 (00806581)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords薬物性歯肉増殖症 / マウスモデル / フェニトイン / ニフェジピン / モデルマウス / NR4A1 / シクロスポリンA
Outline of Final Research Achievements

The applicant conducted a study to investigate whether NR4A1 is a central mechanism of drug induced gingival overgrowth in the model of phenytoin (PHT) and nifedipine (NIF) induced gingival overgrowth. First, to establish PHT and NIF induced gingival overgrowth mice model, we conducted experiments at various concentrations, dosing methods, and dosing times, but did not develop prominent overgrowth. So, PHT and NIF and the effect of NR4A1 on gingival overgrowth was investigated in vitro. As a result, it was shown that in human gingival fibroblasts, NIF and PHT suppress the nuclear translocation of NFATc3 and also suppress the expression of NR4A1, resulting in the enhanced expression of type I collagen.

Academic Significance and Societal Importance of the Research Achievements

本研究は申請者が過去に実施してきたCsA誘導性歯肉増殖症の研究成果をもとに、PHT、NIFで誘導された歯肉増殖症モデルを作製し、NR4A1が薬物性歯肉増殖症メカニズムの中心的な役割を持つ分子であるかを調べることを目的としている。本研究のNR4A1を中心としたメカニズムの解明は、新規治療法や予防法の開発につながり、薬剤変更や外科処置が困難な患者、口腔衛生管理が困難な超高齢の薬物性歯肉増殖症患者にとって大きな負担軽減となる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2019

All Presentation (2 results)

  • [Presentation] ニフェジピン、フェニトイン誘導性歯肉増殖症におけるNR4A1の役割2019

    • Author(s)
      畑野 紗希、松田真司、岡信 愛、加治屋幹人、古玉大祐、目見田匠、藤田 剛、栗原英見
    • Organizer
      第62回秋季日本歯周病学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 薬物性歯肉増殖症のメカニズム解明に向けて2019

    • Author(s)
      國本 愛
    • Organizer
      日本歯周病学会中国四国3大学・日本臨床歯周病学会中国四国支部合同研修会
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2021-02-19  

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