| Project/Area Number |
18K17073
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Kyushu University |
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Principal Investigator |
Yuda Asuka 九州大学, 大学病院, 助教 (20814081)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | PDLIM5 / 仮足形成 / 歯周組織再生 / 歯肉のダウングロース / 仮足形成関連因子 |
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| Outline of Final Research Achievements |
In this study, we investigated the effects of PDLIM5 on association with cell extensions formation and migration activity of human periodontal ligament and gingival epithelial cells. To examine the roles of PDLIM5 in 1-11 and OBA9 cells, PDLIM5 was knocked down by siRNA. We examined formation of cell extentions and migration activities.PDLIM5-knockdown 1-11 cells reduced cell extensions formation and migration activities, compared with control cells. PDLIM5-knockdown OBA9 cells promoted cell extensions formation and migration activities, compared with control cells.
These results suggested that PDLIM5 may regulate of cell extensions formation and migration activity on periodontal ligament and gingival epithelial cells during wound hearing. PDLIM5 would be used as a therapeutic agent for periodontal regeneration.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、PDLIM5はヒト歯根膜細胞の仮足形成、細胞遊走において促進に働くことに対し、ヒト歯肉上皮細胞においては抑制に働く可能性が推察された。PDLIM5がヒト歯根膜細胞およびヒト歯肉上皮細胞に及ぼす影響が検証されれば、歯周組織再生治療の際起こりうる、歯肉のダウングロース防止に応用できる可能性があると考えられる。
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