Development of new bone regeneration therapy using Cluster of DFATs/ECM complex (C-DFAT)
| Project/Area Number |
18K17089
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | DFAT / C-DFAT / 骨再生 / 歯周病 / BMP-9 |
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| Outline of Final Research Achievements |
The purpose of this study was development of new bone regenerative therapy for lost bone tissues due to periodontal and oral disease by using Cluster of DFATs/ECM complex (C-DFAT).I confirmed the formation of C-DFAT which used extracelluar matrix (ECM) which rDFAT produced as a result of this study using rat DFAT(rDFAT) provided by ceiling culture.
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| Academic Significance and Societal Importance of the Research Achievements |
組織幹細胞は加齢とともに減少していくことが知られており、組織内に存在する数も非常に少なくなる。中高年者や高齢者のQOLの維持・増進を考えた時、予知性の高い新規顎骨組織再生療法の開発は歯の保存や、理想的なインプラント治療の提供につながり、社会的見地からも極めて重要な課題である。そこで本研究の目的は、C-DFATの樹立、さらに顎顔面領域における歯周組織欠損、抜歯窩、顎骨再建などの骨欠損部に対して、scaffoldを用いずにC-DFATを細胞移植することで、安全・効率的かつ予知性の高い理想的な骨再生療法の基盤確立を目指すことであった。
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Report
(5 results)
Research Products
(9 results)
