The impact of declines in oral function for developing metabolic syndrome and the components

• Project/Area Number: 18K17117
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Osaka University
• Principal Investigator: Kosaka Takayuki 大阪大学, 歯学研究科, 助教 (40755360)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯学 / 循環器・高血圧 / 衛生 / 老化

Outline of Final Research Achievements

This study assessed the relationship between oral health and general health in a Japanese urban population. Below results were found; 1. We developed a prediction model of masticatory performance change. 2. Periodical utilization of dental services is an effective breakthrough for declining masticatory performance. 3. The lower maximum bite force is a risk factor for developing cardiovascular disease. 4. Decreased masticatory performance is a risk factor for developing metabolic syndrome.

Academic Significance and Societal Importance of the Research Achievements

これまで、メタボリックシンドロームのリスク因子に着目した研究が多く行われる中、口腔の機能低下との関連についてはほとんど検討されていない。本研究では、都市部一般住民を対象とした大規模調査を行い、口腔機能の一つである咀嚼能率について客観的に評価した。その結果、咀嚼能率が低値であると、将来的なメタボリックシンドローム罹患のリスクとなることが明らかになった。本結果は、咀嚼能率の維持が、メタボリックシンドロームの予防に貢献する可能性を示すものである。

Research Products

• [Journal Article] Periodical utilization of dental services is an effective breakthrough for declining masticatory performance: the Suita study (2020)
  • Author(s): Fujii Katsunori, Kosaka Takayuki, Hasegawa Yoko, Kida Momoyo, Hashimoto Sakae, Fushida Shuri, Nokubi Takashi, Kokubo Yoshihiro, Watanabe Makoto, Higashiyama Aya, Miyamoto Yoshihiro, Ikebe Kazunori, Ono Takahiro
  • Journal Title: Odontology Volume: ‐ Issue: 4 Pages: 1-7
  • DOI: 10.1007/s10266-020-00501-3
  • Peer Reviewed / Open Access
• [Journal Article] Decreased masticatory performance is related to increased intima-media thickness in a general urban Japanese population: The Suita study (2020)
  • Author(s): Kida Momoyo、Ono Takahiro、Kokubo Yoshihiro、Yoshimuta Yoko、Kosaka Takayuki、Kikui Miki、Yamamoto Masa-aki、Ikebe Kazunori、Maeda Yoshinobu、Nokubi Takashi、Nishimura Kunihiro、Watanabe Makoto、Higashiyama Aya、Miyamoto Yoshihiro
  • Journal Title: Journal of Prosthodontic Research Volume: 64 Issue: 3 Pages: 346-353
  • DOI: 10.1016/j.jpor.2019.10.001
  • NAID: 130007885705
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed / Open Access
• [Journal Article] Tooth loss leads to reduced nutrient intake in middle-aged and older Japanese individuals. (2019)
  • Author(s): Kosaka T, Kida M
  • Journal Title: Environmental Health and Preventive Medicine Volume: 24(1) Issue: 1 Pages: 15-15
  • DOI: 10.1186/s12199-019-0770-3
  • NAID: 210000130333
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between the burden of major periodontal bacteria and serum lipid profile in a cross-sectional Japanese study (2018)
  • Author(s): Choi Youn-Hee、Kosaka Takayuki、Ojima Miki、Sekine Shinichi、Kokubo Yoshihiro、Watanabe Makoto、Miyamoto Yoshihiro、Ono Takahiro、Amano Atsuo
  • Journal Title: BMC Oral Health Volume: 18 Issue: 1 Pages: 77-77
  • DOI: 10.1186/s12903-018-0536-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Factors influencing the changes in masticatory performance: the Suita study. (2018)
  • Author(s): Kosaka T, Kida M, Kikui M, Hashimoto S, Fujii K, Yamamoto M, Nokubi T, Maeda Y, Hasegawa Y, Kokubo Y, Watanabe M, Higashiyama A, Miyamoto Y, Ono T
  • Journal Title: JDR Clinical & Translational Research Volume: 3(4) Issue: 4 Pages: 405-412
  • DOI: 10.1177/2380084418785863
  • Peer Reviewed / Open Access
• [Presentation] 都市部一般住民における咀嚼能率低下はメタボリックシンドローム罹患のリスクとなる：吹田研究 (2019)
  • Author(s): 伏田朱里、高阪貴之、來田百代、橋本栄、小野高裕、池邉一典
  • Organizer: 日本咀嚼学会第30回記念学術大会
• [Presentation] 都市部一般住民における最大咬合力と循環器病発症との追跡研究：吹田研究 (2019)
  • Author(s): 橋本栄、小野高裕、來田百代、高阪貴之、菊井美希、池邉一典
  • Organizer: 日本補綴歯科学会第128回学術大会
• [Presentation] A prediction model of objective masticatory performance change in 50-70 years old Japanese: the Suita study (2019)
  • Author(s): Kosaka T, Ono T, Kida M, Hashimoto S, Fujii K, Fushida S, Nokubi T, Kokubo Y, Watanabe M, Higshiyama A, Miyamoto Y, Ikebe K
  • Organizer: The 29th Congress of the European College of Gerodontology
  • Int'l Joint Research
• [Presentation] Lower maximum bite force affects the onset of cardiovascular disease (2019)
  • Author(s): Kosaka T, Ono T, Hashimoto S, Kida M, Fushida S, Kokubo Y, Watanabe M, Higashiyama A, Nakai M, Miyamoto Y, Ikebe K
  • Organizer: 4th Meeting of the International Association for Dental Research, Asian Pacific Region
  • Int'l Joint Research
• [Presentation] Impact of the state of dentition on objective masticatory performance in elderly (2018)
  • Author(s): Kosaka T
  • Organizer: IADE GORG Symposium
  • Int'l Joint Research / Invited
• [Presentation] 口腔と全身の関わり－都市部コホート研究より得られたエビデンス－ (2018)
  • Author(s): 高阪貴之
  • Organizer: 第7回日本精神科医学会学術大会
  • Invited
• [Presentation] 都市部一般住民における咀嚼能率低下予測モデルの開発－吹田研究－ (2018)
  • Author(s): 高阪貴之，小野高裕，來田百代，菊井美希，橋本栄，藤井克則，伏田朱里，小久保喜弘，野首孝祠，池邉一典
  • Organizer: 第29回日本咀嚼学会学術大会