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Improving the histological weakness of transcutaneous implants in maxillofacial prosthetic treatment

Research Project

Project/Area Number 18K17124
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionKyushu University

Principal Investigator

Narimatsu Ikue  九州大学, 歯学研究院, 助教 (70808146)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsインプラント / 軟組織 / 顎顔面補綴
Outline of Final Research Achievements

Defects in the maxillofacial region are severe and complex. Implants are applied as a structural base for maxillofacial prostheses; however, the success rate of maxillofacial implants is currently low.
This study focused on the soft tissue around implants that penetrate the oral mucosa and skin. Epithelial and fibroblast cells from rat oral mucosa and back skin were collected and cultured on titanium plates. The maxillary first molars of rats were extracted, and experimental implants were placed.
Evaluation of peri-implant soft tissue sealing revealed that the predominant surface properties differed between the epithelium and connective tissue. Additionally, the soft tissue sealing ability around implants was found to be inferior to that of natural teeth. These findings suggest that improvement in the surface properties of the implant and the soft tissue sealing ability may affect the success of implant treatment.

Academic Significance and Societal Importance of the Research Achievements

本研究結果は顎顔面インプラント治療の安定した提供、つまり、成功率の向上に寄与すると考える。さらに、今後の顎顔面補綴臨床を歯科発信の技術で大きく変革し、歯科医学・医療の目標である健康・福祉の向上に大きく貢献すると思われる。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (24 results)

All 2022 2021 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (18 results) (of which Int'l Joint Research: 9 results)

  • [Journal Article] The need for polishing and occlusal adjustment of zirconia prostheses for wear on antagonist teeth2021

    • Author(s)
      Tachibana Keishu, Atsuta Ikiru, Tsukiyama Yoshihiro, Kuwatsuru Rika, Morita Takehiro, Yoshimatsu Hiroya, Matsushita Yasuyuki, Narimatsu Ikue, Ayukawa Yasunori, Sawae Yoshinori, Koyano Kiyoshi
    • Journal Title

      Dental Materials Journal

      Volume: advpub Issue: 0 Pages: 650-656

    • DOI

      10.4012/dmj.2020-190

    • NAID

      130008045402

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Replacement Process of Carbonate Apatite by Alveolar Bone in a Rat Extraction Socket2021

    • Author(s)
      Xiaoxu Zhang , Ikiru Atsuta , Ikue Narimatsu , Nobuyuki Ueda , Ryosuke Takahashi , Yuki Egashira , Jing-Qi Zhang , Jiong-Yan Gu , Kiyoshi Koyano , Yasunori Ayukawa
    • Journal Title

      Materials

      Volume: 14(16) Issue: 16 Pages: 4457-4457

    • DOI

      10.3390/ma14164457

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of titanium or zirconia implant abutments on epithelial attachments after ultrasonic cleaning2020

    • Author(s)
      Hu Jiangqi,Atsuta Ikiru,Ayukawa Yasunori,Zhou Tianren,Narimatsu Ikue,Koyano Kiyoshi
    • Journal Title

      Journal of Oral Science

      Volume: 62 Issue: 3 Pages: 331-334

    • DOI

      10.2334/josnusd.19-0332

    • NAID

      130007863824

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epithelial and Connective Tissue Sealing around Titanium Implants with Various Typical Surface Finishes2019

    • Author(s)
      Narimatsu Ikue, Atsuta Ikiru, Ayukawa Yasunori, Oshiro Wakana, Yasunami Noriyuki, Furuhashi Akihiro, Koyano Kiyoshi
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 5 Issue: 10 Pages: 4976-4984

    • DOI

      10.1021/acsbiomaterials.9b00499

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel Application Method for Mesenchymal Stem Cell Therapy Utilizing Its Attractant-Responsive Accumulation Property2019

    • Author(s)
      Ueda Nobuyuki, Atsuta Ikiru, Ayukawa Yasunori, Yamaza Takayoshi, Furuhashi Akihiro, Narimatsu Ikue, Matsuura Yuri, Kondo Ryosuke, Watanabe Yu, Zhang Xiaoxu, Koyano Kiyoshi
    • Journal Title

      Applied Sciences

      Volume: 9 Issue: 22 Pages: 4908-4908

    • DOI

      10.3390/app9224908

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epithelial sealing effectiveness against titanium or zirconia implants surface2019

    • Author(s)
      Atsuta Ikiru、Ayukawa Yasunori、Furuhashi Akihiro、Narimatsu Ikue、Kondo Ryosuke、Oshiro Wakana、Koyano Kiyoshi
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: - Issue: 7 Pages: 1379-1385

    • DOI

      10.1002/jbm.a.36651

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Role of stem cells around carbonate apatite as bone substitute2022

    • Author(s)
      Takahashi Ryosuke, Atsuta Ikiru, Narimatsu Ikue, Zhang Xiaoxu, Egashira Yuki, Koyano Kiyoshi, Ayukawa Yasunori
    • Organizer
      2022 IADR/APR General Session & Exhibition
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 炭酸アパタイト製骨補填材が間葉系幹細胞に及ぼす影響について2022

    • Author(s)
      髙橋良輔,熱田生,成松生枝,張暁旭,江頭優希,古谷野潔,鮎川保則
    • Organizer
      第51回日本口腔インプラント学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Effect of carbonate apatite as bone substitute from the perspective of mesenchymal stem cells2022

    • Author(s)
      Takahashi Ryosuke, Atsuta Ikiru, Narimatsu Ikue, Zhang Xiaoxu, Egashira Yuki, Koyano Kiyoshi, Ayukawa Yasunori
    • Organizer
      Kyudai Oral Bioscience & OBT Research Center 6th Joint International Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 炭酸アパタイト製骨補填材周囲における間葉系幹細胞の役割について2021

    • Author(s)
      高橋良輔,熱田生,成松生枝,張暁旭,江頭優希,古谷野潔,鮎川保則
    • Organizer
      令和3年度公益社団法人日本補綴歯科学会九州支部学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 炭酸アパタイト製骨補填材周囲における間葉系幹細胞の役割について2021

    • Author(s)
      高橋良輔,熱田生,成松生枝,張暁旭,江頭優希,古谷野潔,鮎川保則
    • Organizer
      日本口腔インプラント学会第51回本部学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 炭酸アパタイト製骨補填材を介した骨形成における間葉系幹細胞の役割2021

    • Author(s)
      高橋良輔,熱田生,成松生枝,張暁旭,江頭優希,古谷野潔,鮎川保則
    • Organizer
      日本歯科理工学会九州地方会冬期セミナー
    • Related Report
      2021 Research-status Report
  • [Presentation] Epithelial and Connective Tissue Sealing around Titanium Implants with Various Typical Surface Finishes2021

    • Author(s)
      Narimatsu Ikue, Atsuta Ikiru, Ayukawa Yasunori, Oshiro Wakana,Yasunami Noriyuki, Furuhashi Akihiro, Koyano Kiyoshi
    • Organizer
      Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2021
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット抜歯窩の治癒過程から見る炭酸アパタイト骨補填材の有効性2020

    • Author(s)
      張暁旭,熱田生,鮎川保則,成松生枝,上田将之,高橋良輔,江頭優希,張旌旗,顧炯炎,古谷野潔
    • Organizer
      日本歯科理工学会九州地方会秋期セミナー
    • Related Report
      2020 Research-status Report
  • [Presentation] Replacement Process of Carbonate Apatite by Alveolar Bone in Rat Extraction Socket2020

    • Author(s)
      Zhang X, Atsuta I, Ayukawa Y, Narimatsu I, Ueda N, Zhang J, Gu J, Kihara M, Koyano K
    • Organizer
      AO Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of Cytrans granules as a Bone Substitute on Oral Mucosal Healing in Rat Extraction Socket2020

    • Author(s)
      Atsuta I, Ayukawa Y, Egashira Y, Narimatsu I, Zhang X, Hu J, Sugi T, Wachi S, Ueda N, Koyano K
    • Organizer
      IADR/AADR/CADR General Session
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔粘膜上皮はブリッジのポンティック底部に対して接着性を有するか?2019

    • Author(s)
      熱田生,鮎川保則,森山太一朗,古橋明大,成松生枝,古谷野潔
    • Organizer
      第128回公益社団法人日本補綴歯科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 口腔粘膜と接着するために必要なブリッジポンティック底部の条件とは?2019

    • Author(s)
      熱田生,鮎川保則,森山太一朗,古橋明大,成松生枝,古谷野潔
    • Organizer
      令和元年度公益社団法人日本補綴歯科学会九州支部会
    • Related Report
      2019 Research-status Report
  • [Presentation] 創傷治癒促進を目指した間葉系幹細胞の新規投与法についての検討2019

    • Author(s)
      上田将之,熱田生,鮎川保則,近藤綾介,松浦由梨,成松生枝,張暁旭,古谷野潔
    • Organizer
      日本口腔インプラント学会第49回本部学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Epithelial and connective tissue sealing around titanium implants with various typical surface finishes2019

    • Author(s)
      Narimatsu I, Ayukawa Y, Atsuta I, Oshiro W, Yasunami N, Furuhashi A, Koyano K
    • Organizer
      2019 Joint Meeting of the ICP and EPA
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Advanced Procedure for Systemic Injection of Mesenchymal Stem Cells with Collagen Gel For Healing of Tooth Extraction Sockets in Mice2019

    • Author(s)
      Ueda Nobuyuki, Atsuta Ikiru, Ayukawa Yasunori, Yamaza Takayoshi, Furuhashi Akihiro, Narimatsu Ikue, Matsuura Yuri, Kondo Ryosuke, Watanabe Yu, Koyano Kiyoshi
    • Organizer
      Academy of Osseointegration 2019 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of implant surface modifications subsequent to the application of different methods2019

    • Author(s)
      Hu Jiangqi, Atsuta Ikiru, Ayukawa Yasunori, Zhou Xudiyang, Zhou Tianren, Narimatsu Ikue, Imai Mikio, Koyano Kiyoshi
    • Organizer
      2019 Biennial Joint Congress of CPS-JPS-KAP
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of different divalent cation hydrothermal treatment of titanium on early peri-implant epithelium sealing2019

    • Author(s)
      Zhou Xudiyang, Ayukawa Yasunori, Atsuta Ikiru, Hu Jiangqi, Zhou Tianren, Narimatsu Ikue, Imai Mikio, Koyano Kiyoshi.
    • Organizer
      2019 Biennial Joint Congress of CPS-JPS-KAP
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 軟組織細胞親和性向上を目指したチタン表面処理技術2018

    • Author(s)
      坂本安繁, 鮎川保則, 古橋明大, 熱田生, 原口拓也, Rakhmatia Yunia Dwi, 成松生枝, 古谷野潔
    • Organizer
      日本歯科理工学会九州地方会夏期セミナー
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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