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Mechanism clarification of peri-implantitis based on bone quality

Research Project

Project/Area Number 18K17126
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionNagasaki University

Principal Investigator

KATO Hatsumi  長崎大学, 医歯薬学総合研究科(歯学系), 研究協力員 (30613608)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsインプラント周囲炎 / 荷重 / 細菌感染 / 炎症 / 骨質 / 骨関連細胞 / コラーゲン / インプラント
Outline of Final Research Achievements

Implant treatment is useful option to restore missing teeth. However, many patients have received periimplantitis as previously described clinical reports. No definitive treatment methods have been developed due to unknown mechanisms of periimplantitis. Thus, we hypothesized that bacterial and mechanical loads are required to induce periimplantitis. We created periimplantitis rat model in this study. Moreover, histopathological and immunopathological conditions in periimplantitis were clearly analyzed with this model. Our findings may contribute to the exploration of pathogenesis of periimplantitis.

Academic Significance and Societal Importance of the Research Achievements

インプラント治療が多く行われるようになってきた昨今ですが,インプラント周囲炎は治療法がないにもかかわらず多くの患者さんが罹患するため,現在大きな問題となっています.この研究では,ラットを用いて新しいインプラント周囲炎モデルを確立したことから,学術的な価値があるといえます.また,インプラント周囲炎の原因を究明する基盤構築研究であり,インプラント周囲炎の治療法開発に寄与できる可能性が高いことが社会的意義であるといえます.

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2019

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] ラット上顎骨に埋入したインプラントへの繰り返し荷重がインプラント周囲骨組織のリモデリングに与える影響2019

    • Author(s)
      右藤友督,黒嶋伸一郎,内田悠介,叶井里歩,鈴江正義,澤瀬 隆
    • Organizer
      第49回公益社団法人日本口腔インプラント学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 規則的な繰返し荷重は顎骨に埋入されたインプラント周囲骨組織の荷重応答性適応変化を誘導する2019

    • Author(s)
      右藤友督,黒嶋伸一郎,内田悠介,叶井里歩,鈴江正義,澤瀬 隆
    • Organizer
      第5回日本骨免疫学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Mechanical repetitive loads regulate bone related cells around the osseointegrated implants in rat maxillae2019

    • Author(s)
      Uto Y, Kuroshima S, Uchida Y, Kanai R, Suzue M, Sawase T
    • Organizer
      29th Australian and New Zealand Bone and Mineral Sosiety Annual Scientific Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2021-02-19  

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