| Project/Area Number |
18K17131
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 唾液腺 / 分泌機能亢進因子 / 細胞増殖 / BMP2 / 耳下腺初代培養細胞 / 分泌機能亢進 |
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| Outline of Final Research Achievements |
The purpose of this study is to identify factors that enhance secretory function in salivary glands with reduced secretory function. The unilateral parotid gland excretory duct of the mouse was ligated to prepare a mouse model of unilateral parotid gland injury. Analysis using DNA microarray was performed using the injured, non-injured and control parotid glands. Candidates for secretory function-enhancing factors were extracted from genes whose expression levels were more than doubled in the injured parotid gland as compared to the control parotid gland. In this study, we focused on Bmp2, which is involved in cell differentiation and proliferation, as a candidate for enhancing salivary gland secretion function. It was revealed that BMP2 has the effect of promoting cell proliferation of primary cultured cells of parotid gland acinar cells.
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| Academic Significance and Societal Importance of the Research Achievements |
唾液は口腔内環境を健康に保つために重要な役割を果たしている。高齢者は唾液の分泌量が低下することが知られている。本研究では、唾液分泌機能亢進因子としてBMP2を見出し、BMP2は腺房細胞を増殖させる役割があることを明らかにした。高齢化が進み、３人に１人が総義歯を使用する現在の社会において、唾液は義歯吸着にも関与していることから、唾液を産生する腺房細胞を増殖させる因子を見出したことは大変大きな意義がある。唾液の分泌機能を回復させる研究としては、器官再生による再生医療の研究が盛んにおこなわれている中で、高齢者へ侵襲がより少ない方法で唾液腺機能の回復を目指すことは学術的にも大いに意義がある。
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