| Project/Area Number |
18K17140
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISHIYAMA Hiroyuki 東京医科歯科大学, 東京医科歯科大学病院, 特任助教 (50782273)
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|---|
| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 閉塞性睡眠時無呼吸 / 口腔内装置 / 上下一体型 / 上下分離型 / 治療効果 / 患者満足度 / 副作用 / QOL / 口腔内装置治療 / 分離型装置の有効性 / 閉塞性睡眠時無呼吸症 / 分離型 / 治療効果・QOL |
|---|
| Outline of Final Research Achievements |
Oral appliance (OA) therapy for obstructive sleep apnea (OSA) can be structurally classified into mono-block and bi-block OA. The aim of this study was to conduct a systematic review and meta-analysis to determine which structure is more effective before proceeding with a prospective, comparative study of mono-block OA and bi-block OA. After secondary screening, two articles remained, and a meta-analysis showed that mono-block OA significantly reduced the apnea-hypopnea index (AHI) and significantly increased patient satisfaction compared to bi-block OA. Therefore, it was shown that mono-block OA was more effective than bi-block OA in OA therapy for OSA patients.
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| Academic Significance and Societal Importance of the Research Achievements |
OAの構造について, これまで一体型, 分離型どちらが有効かについて議論が分かれていたが, 本研究の結果は臨床医がOA療法を際, 装置の設計を考える上での指標となる. 一体型OAはOSA治療効果だけでなく, 患者満足度も良いという事から, 総合的にも有効な装置である事が示された.
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