| Project/Area Number |
18K17145
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 睡眠時ブラキシズム / ウルトラディアンリズム / 顎運動 / 脳波 / パワースペクトラル解析 / 動物モデル / ウレタン / 咀嚼リズム / ブラキシズム / 睡眠 / 麻酔 |
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| Outline of Final Research Achievements |
This study investigated the oromotor activity under urethane anesthesia in guinea pigs. The results showed that cortical brain states changed cyclically after intraperitoneal injection of urethane. Brain states were classified into NREM-like, REM-like and transition states according to the delta and theta cortical activities. In relation to the changes of the brain states, the patterns of jaw movements were altered. Repetitive lateral jaw movements were found to occur in cluster. The jaw movements were associated with the intense masseter muscle contractions but not with digastric muscle contractions. Moreover, this episode often occur with tooth grinding noise.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究から、ウレタン麻酔下で生じる周期的な脳波活動状態の変化に伴って、顎の運動を調節する神経ネットワークの活動モードが変化することから、脳内全体の活動のバランスの変化が、無意識下で発生する歯ぎしりの発生要因であることを示唆する点で学術的に重要である。本研究成果は、歯ぎしり発生の神経メカニズムを明らかにする解明したり、治療法や診断方法を開発するうえで有用な新しい実験系を開発できた点で意義がある。
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