• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Novel Bone Quality Regulation Strategy Focused on Inter-organ Networks by Glucose and Bone Metabolism Crosstalk

Research Project

Project/Area Number 18K17154
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionKyushu Dental College

Principal Investigator

Aonuma Fumiko  九州歯科大学, 歯学部, 医員 (60815900)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨代謝 / 糖代謝 / 骨造成 / OVX / メトホルミン / 骨粗鬆症 / 臓器間ネットワーク / 糖代謝改善薬 / 骨質改善
Outline of Final Research Achievements

It is believed that osteoporosis induces bone resorption in implant therapy and osteogenic surgery for this purpose, and that new bone formation is significantly reduced even after osteogenic surgery. Recently, the relationship between bone metabolism and glucose metabolism has been attracting attention, and since it is thought that glucose metabolism drugs may also affect bone metabolism and wound healing, we investigated this using a rat model of osteoporosis. The results suggest that therapeutic agents for glucose metabolism may affect the maintenance of bone formation and wound healing after osteogenic surgery in osteoporosis model rats.

Academic Significance and Societal Importance of the Research Achievements

近年、骨代謝と糖代謝との関連が注目され、糖代謝治療薬が骨代謝や創傷治癒にも影響を及ぼすことが考えられている。実際に、糖代謝治療薬は骨代謝に微弱ながらも影響を与え、骨の治癒改善に役立つ可能性があることが示唆された。現在、骨粗鬆症治療薬のBP製剤には歯科治療を契機とした顎骨壊死や骨の治癒遅延などが起こることが問題となっている。経口で使用できる糖代謝治療薬は、顎骨壊死のリスクも低く、安価で広く一般に使用することができることから、今後のインプラント治療やインプラント治療を目的とした骨造成手術において骨代謝の改善に寄与する可能性があると考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2021

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Effects of metformin on the prevention of bisphosphonate-related osteonecrosis of the jaw-like lesions in rats2021

    • Author(s)
      Nakagawa Tomohito、Tsuka Shintaro、Aonuma Fumiko、Nodai Tomotaka、Munemasa Takashi、Tamura Akiko、Mukaibo Taro、Kondo Yusuke、Masaki Chihiro、Hosokawa Ryuji
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 65 Issue: 2 Pages: 219-224

    • DOI

      10.2186/jpr.JPOR_2019_629

    • NAID

      130008059338

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi