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Differentiation and physiological function analysis of osteoclasts using Raman spectroscopy and its application to elucidation of the pathogenesis of osteonecrosis of the jaw

Research Project

Project/Area Number 18K17175
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionKyoto Institute of Technology

Principal Investigator

Marin Elia  京都工芸繊維大学, 材料化学系, 准教授 (10814014)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsラマン / 骨 / 骨壊死 / 顎骨壊死 / 破骨細胞 / ラマン分光法 / 薬剤関連顎骨壊死 / MRONJ / ビスホスホネート / BRONJ
Outline of Final Research Achievements

By using Raman spectroscopy, we were able to understand the changes in structure and microstructure of bone samples due to the effects of osteonecrosis, and in particular the loss of mineralization and the changes in the composition of the bone collagen. These information were obtained by samples acquired from patients, and we were able to notice differences in osteonecrosis caused by alcohol and osteonecrosis caused by the assumption of steroids. Overall, Raman spectroscopy proved to be a powerful tool in the study of human bone, able to assess the quality of both the mineral and the organic fraction. Moreover, Raman spectroscopy could be used as an imaging tool, giving accurate chemical maps of the structure and composition of large areas of bone.

Academic Significance and Societal Importance of the Research Achievements

この研究の科学的な重要性は、骨吸収細胞の分化と骨リモデリングのプロセスに対する理解に貢献する点にあります。RANKLとビスホスホネートがデンチン基質に及ぼす影響に関する洞察を提供し、骨の生物学に関する知識を進め、骨関連疾患の治療戦略につながる可能性があります。

社会的な観点から見ると、この研究は医療の向上と、人口の大部分に影響を及ぼす骨の疾患の対処に重要です。より良い治療法の開発につながり、生活の質を向上させ、医療費を削減することが期待されます。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2022

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 2 results)

  • [Journal Article] PCA-Assisted Raman Analysis of Osteonecrotic Human Femoral Heads2022

    • Author(s)
      Ishimura Eiji、Zhu Wenliang、Marin Elia、Honma Taigi、Sugano Nobuhiko、Ando Wataru、Pezzotti Giuseppe
    • Journal Title

      Methods and Protocols

      Volume: 5 Issue: 1 Pages: 10-10

    • DOI

      10.3390/mps5010010

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Innovative electrospun PCL/fibroin/l-dopa scaffolds scaffolds supporting bone tissue regeneration2022

    • Author(s)
      Marin Elia、Yoshikawa Orion、Boschetto Francesco、Honma Taigi、Adachi Tetsuya、Zhu Wenliang、Xu Huaizhong、Kanamura Narisato、Yamamoto Toshiro、Pezzotti Giuseppe
    • Journal Title

      Biomedical Materials

      Volume: 17 Issue: 4 Pages: 045010-045010

    • DOI

      10.1088/1748-605x/ac6c68

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Raman Spectroscopic Investigation of Osteoclastic Activity under the Influence of Bisphosphonate2022

    • Author(s)
      Marin Elia、Adachi Tetsuya、Boschetto Francesco、Zhu Wenliang、Adachi Keiji、Kanamura Narisato、Yamamoto Toshiro、Pezzotti Giuseppe
    • Journal Title

      Applied Sciences

      Volume: 12 Issue: 8 Pages: 3757-3757

    • DOI

      10.3390/app12083757

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2018-04-23   Modified: 2024-01-30  

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