| Project/Area Number |
18K17185
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Osaka Medical and Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 生体材料 / 人工骨 / バイオマテリアル / 積層造形 / チタン / 表面処理 / 骨再生 / 混酸・加熱処理 / 骨セメント / 口腔顎顔面債権外科 / 抗菌性チタン人工骨 / 再生医療 / 純チタン粒子 / 積層造形チタン |
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| Outline of Final Research Achievements |
Autogenous or artificial bone graft has been operated for bone defects caused by tumors and traumas. However, autogenous bone graft has been considered to have several disadvantages such as the limited quantities available, donor-site morbidity and postoperative inflammation. Whereas artificial bone graft has not had sufficient strength or sculpted various shapes. These problems could make it difficult to reproduce the appearance and could cause postoperative inflammation.
In this study, Selective Laser Melting (SLM) titanium artificial bone which is sculpted in various shapes has been manufactured and applied various surfaces treatment to develop new bioactive titanium artificial bone and new bone cement to be fixed.
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| Academic Significance and Societal Importance of the Research Achievements |
この研究では、選択的レーザー溶融法(SLM法)を用いて、いかなる形態の骨欠損部にも適合可能な積層造形チタン人工骨を作製、さらに骨再生能を持つ表面処理を施した生体活性型チタン人工骨と人工骨固定のための新規骨セメントの開発を行い実用化のための基礎データとした。すでに基礎医療分野で研究されている、金属粒子に抗菌力を付与する最新技術をハイブリッドさせ、人工骨のコアマテリアルである純チタン微粒子に抗菌力を付与することで、世界初の抗菌力を有するチタン人工骨および骨セメントの開発が可能であると考えている。
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