• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of antibacterial additive manufacturing titanium artificial bone using HDSI method.

Research Project

Project/Area Number 18K17185
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionOsaka Medical and Pharmaceutical University

Principal Investigator

Yamamoto Kayoko  大阪医科薬科大学, 医学部, 助教 (70814094)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体材料 / 人工骨 / バイオマテリアル / 積層造形 / チタン / 表面処理 / 骨再生 / 混酸・加熱処理 / 骨セメント / 口腔顎顔面債権外科 / 抗菌性チタン人工骨 / 再生医療 / 純チタン粒子 / 積層造形チタン
Outline of Final Research Achievements

Autogenous or artificial bone graft has been operated for bone defects caused by tumors and traumas. However, autogenous bone graft has been considered to have several disadvantages such as the limited quantities available, donor-site morbidity and postoperative inflammation. Whereas artificial bone graft has not had sufficient strength or sculpted various shapes. These problems could make it difficult to reproduce the appearance and could cause postoperative inflammation.
In this study, Selective Laser Melting (SLM) titanium artificial bone which is sculpted in various shapes has been manufactured and applied various surfaces treatment to develop new bioactive titanium artificial bone and new bone cement to be fixed.

Academic Significance and Societal Importance of the Research Achievements

この研究では、選択的レーザー溶融法(SLM法)を用いて、いかなる形態の骨欠損部にも適合可能な積層造形チタン人工骨を作製、さらに骨再生能を持つ表面処理を施した生体活性型チタン人工骨と人工骨固定のための新規骨セメントの開発を行い実用化のための基礎データとした。すでに基礎医療分野で研究されている、金属粒子に抗菌力を付与する最新技術をハイブリッドさせ、人工骨のコアマテリアルである純チタン微粒子に抗菌力を付与することで、世界初の抗菌力を有するチタン人工骨および骨セメントの開発が可能であると考えている。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (32 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (11 results) (of which Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (21 results) (of which Int'l Joint Research: 11 results,  Invited: 1 results)

  • [Journal Article] Characterization of Oral Microbiota Following Chemotherapy in Patients With Hematopoietic Malignancies2023

    • Author(s)
      Omori Michi、Kato-Kogoe Nahoko、Sakaguchi Shoichi、Komori Eri、Inoue Kazuya、Yamamoto Kayoko、Hamada Wataru、Hayase Tomoyoshi、Tano Tomoyuki、Nakamura Shota、Nakano Takashi、Une Hidenori、Ueno Takaaki
    • Journal Title

      Integrative Cancer Therapies

      Volume: 22 Pages: 1-11

    • DOI

      10.1177/15347354231159309

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of Implant Stability Quotient Values of Dental Implants Placed in Vascularized Bone Grafts2022

    • Author(s)
      Matsumoto Keisuke、Mano Takamitsu、Inoue Kazuya、Yamamoto Kayoko、Imagawa Naoko、Takahashi Ayaka、Ueno Takaaki
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 31 Issue: 1 Pages: 55-58

    • DOI

      10.2485/jhtb.31.55

    • NAID

      130008149075

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2021 Research-status Report
  • [Journal Article] Mechanical, Histological, and Scanning Electron Microscopy Study of the Effect of Mixed-Acid and Heat Treatment on Additive-Manufactured Titanium Plates on Bonding to the Bone Surface2020

    • Author(s)
      Imagawa Naoko、Inoue Kazuya、Matsumoto Keisuke、Ochi Ayako、Omori Michi、Yamamoto Kayoko、Nakajima Yoichiro、Kato-Kogoe Nahoko、Nakano Hiroyuki、Matsushita Tomiharu、Yamaguchi Seiji、Thi Minh Le Phuc、Maruyama Shinpei、Ueno Takaaki
    • Journal Title

      Materials

      Volume: 13 Issue: 22 Pages: 5104-5104

    • DOI

      10.3390/ma13225104

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Preliminary Study of the Relationship between Oral and Vascular Function in the Elderly Population2020

    • Author(s)
      Suzuki Kei、Nakano Hiroyuki、Kato-Kogoe Nahoko、Inoue Kazuya、Omori Michi、Imagawa Naoko、Suwa Yoshifumi、Yamamoto Kayoko、Kamiya Kuniyasu、Ikehara Satoyo、Tamaki Junko、Hoshiga Masaaki、Ueno Takaaki
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 29 Issue: 3 Pages: 161-164

    • DOI

      10.2485/jhtb.29.161

    • NAID

      130007877474

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between Oral Function and Occlusal Bite Force in the Elderly2020

    • Author(s)
      Imagawa Naoko、Kato-Kogoe Nahoko、Suzuki Kei、Omori Michi、Suwa Yoshifumi、Inoue Kazuya、Nakano Hiroyuki、Yamamoto Kayoko、Kamiya Kuniyasu、Ikehara Satoyo、Hoshiga Masaaki、Tamaki Junko、Kawata Ryo、Ueno Takaaki
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 29 Issue: 3 Pages: 165-168

    • DOI

      10.2485/jhtb.29.165

    • NAID

      130007877471

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Removal of a Fixation Screw That Was Forced Into the Postsuperior Maxillary Sinus Wall2019

    • Author(s)
      Nakajima Yoichiro、Omori Michi、Inoue Kazuya、Nakano Hiroyuki、Fukui Nozomu、Kato-Kogoe Nahoko、Yamamoto Kayoko、Suwa Yoshifumi、Sunano Akihiro、Ueno Takaaki
    • Journal Title

      Implant Dentistry

      Volume: 28 Issue: 3 Pages: 313-316

    • DOI

      10.1097/id.0000000000000867

    • Related Report
      2019 Research-status Report
  • [Journal Article] Reconstruction of the Alveolar Bone Using Bone Augmentation With Selective Laser Melting Titanium Mesh Sheet2018

    • Author(s)
      Inoue Kazuya、Nakajima Yoichiro、Omori Michi、Suwa Yoshifumi、Kato-Kogoe Nahoko、Yamamoto Kayoko、Kitagaki Hisashi、Mori Shigeo、Nakano Hiroyuki、Ueno Takaaki
    • Journal Title

      Implant Dentistry

      Volume: 27 Issue: 5 Pages: 602-607

    • DOI

      10.1097/id.0000000000000822

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Guided Bone Regeneration Using the Bone Substitute Bio-Oss<sup>®</sup> and a Collagen Membrane in a Rat Cranial Bone Defect Model2018

    • Author(s)
      Shin Kasuya, Shihoko Inui, Nahoko Kato-Kogoe, Michi Omori, Kayoko Yamamoto,Kazuya Inoue, Yuichi Ito, Yoichiro Nakajima, Azumi Hirata and Takaaki Ueno
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 27 Issue: 1 Pages: 79-84

    • DOI

      10.2485/jhtb.27.79

    • NAID

      130006302032

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteogenic capacity of mixed-acid and heat-treated titanium mesh prepared by a selective laser melting technique2018

    • Author(s)
      Yamamoto Kayoko、Yamaguchi Seiji、Matsushita Tomiharu、Mori Shigeo、Hirata Azumi、Kato-Kogoe Nahoko、Nakano Hiroyuki、Nakajima Yoichiro、Nishitani Yoshihiro、Nagatsuka Hitoshi、Ueno Takaaki
    • Journal Title

      RSC Advances

      Volume: 8 Issue: 46 Pages: 26069-26077

    • DOI

      10.1039/c8ra04193h

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] New Bone Formation Process Using Bio-Oss and Collagen Membrane for Rat Calvarial Bone Defect2018

    • Author(s)
      Kasuya Shin、Kato-Kogoe Nahoko、Omori Michi、Yamamoto Kayoko、Taguchi Shogo、Fujita Hiroshi、Imagawa Naoko、Sunano Akihiro、Inoue Kazuya、Ito Yuichi、Hirata Azumi、Ueno Takaaki、Moy Peter K.
    • Journal Title

      Implant Dentistry

      Volume: 27 Issue: 2 Pages: 158-164

    • DOI

      10.1097/id.0000000000000738

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biological Safety of Mixed Acid Heat Treatment in SLM (Selective Laser Melting Technique) Titanium Mesh2018

    • Author(s)
      Inui Shihoko、Yamamoto Kayoko、Kato-Kogoe Nahoko、Nakajima Yoichiro、Inoue Kazuya、Nakano Hiroyuki、Yamaguchi Seiji、Hirata Azumi、Kondo Yoichi、Ueno Takaaki
    • Journal Title

      Journal of Oral Tissue Engineering

      Volume: 16 Pages: 27-31

    • NAID

      130007608264

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Evaluation of postoperative oral function for patients following mandibular reconstruction.2022

    • Author(s)
      Kayoko Yamamoto, Kazuya Inoue, Nahoko Kato-Kogoe, Yoichiro Nakajima, Takamitsu Mano, Ian Matthew, Takaaki Ueno.
    • Organizer
      The 26th EACMFS Congress.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯科インプラント埋入部位に発症した広範囲薬剤関連顎骨壊死の一例.2022

    • Author(s)
      山本佳代子、井上和也 、有吉靖則 、中島世市郎、真野隆充、植野高章.
    • Organizer
      第67回日本口腔外科学会総会・学術大会.
    • Related Report
      2022 Annual Research Report
  • [Presentation] Dental education at medical college: the importance of interprofessional collaboration.2022

    • Author(s)
      Kayoko Yamamoto.
    • Organizer
      The 2nd Annual Meeting of the International Society of Oral Care.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Full custom titanium membrane usage for bone augmentation of dental implant treat- ment to recover lost occlusal function.2022

    • Author(s)
      Kayoko Yamamoto, Takaaki Ueno, Yoichiro Nakajima, Hiroyuki Nakano, Kazuya Inoue.
    • Organizer
      The 2nd Annual Meeting of the International Society of Oral Care.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chondrogenesis potential of free grafted peri- osteum in rat experimental model.2022

    • Author(s)
      Kayoko Yamamoto, Hiroyuki Nakano, Yoichiro Nakajima, Takaaki Ueno, Kazuya Inoue.
    • Organizer
      The 2nd Annual Meeting of the International Society of Oral Care.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Shine a light on the importance of oral care on malnourished patients; the experience of NST and Oral Care Team.2022

    • Author(s)
      Kayoko Yamamoto, Mariko Urase, Tomomi Higashio, Ryo Tanaka, Norio Kanatsuna, Sang-Woong Lee, Takaaki Ueno.
    • Organizer
      The 2nd Annual Meeting of the International Society of Oral Care.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oral care management and its role in pallia- tive care patients.2022

    • Author(s)
      Kayoko Yamamoto, Ken Asaishi, Minako Nagaeki, Shinya Kinoshita, Keiji Nihei, Takaaki Ueno.
    • Organizer
      The 2nd Annual Meeting of the International Society of Oral Care.
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of titanium mesh sheet prepared by selective laser melting technique for alveolar ridge augmentation: clinical case reports.2021

    • Author(s)
      1.Yamamoto K, Kato-Kogoe N, Imagawa N, Inoue K, Nakajima Y, Nakano H, Matthew I, Ueno T
    • Organizer
      The 25th European Association for Cranio-Maxillo-Facial Surgery
    • Related Report
      2021 Research-status Report
  • [Presentation] Good oral health is important: the reality of dental care in Canada.2021

    • Author(s)
      Yamamoto K
    • Organizer
      The 1st Annual Meeting of the International Society of Oral Care
    • Related Report
      2021 Research-status Report
  • [Presentation] Apatite formation of blast and acid etched commercial dental Ti implant induced by heat treatment: effect of kinds of blast particles on apatite formation2020

    • Author(s)
      Ogura A, Yamaguchi S, Yamamoto K, Inoue K, Nakajima Y, Nakano H, Ueno T
    • Organizer
      11th World Biomaterials Congress
    • Related Report
      2020 Research-status Report
  • [Presentation] 造血器腫瘍患者の化学療法によるOral Microbiomeの変化に関するメタゲノム解析2020

    • Author(s)
      大森実知,小越菜保子,福居希,越智文子,山本佳代子,寺井陽彦,早瀬友克,田野智之,宇根秀則,植野高章
    • Organizer
      第65回日本口腔外科学会総会・学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 埋入部位がインプラント安定指数(ISQ値)に及ぼす影響2020

    • Author(s)
      松本佳輔,井上和也,中島世市郎,山本佳代子,今川尚子,田口尚吾,諏訪吉史,植野高章
    • Organizer
      第50回日本口腔インプラント学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Mechanical properties of chemical treated titanium-enriched glass ionomer cement2020

    • Author(s)
      Yamamoto K, Palma-Dibb RG, Ueno T, Manso AP, Carvalho RM
    • Organizer
      The 98th International Association for Dental Research General Session
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 下顎骨C Tデータから取得したパラメータの性識別判定への有効性の検証2019

    • Author(s)
      鈴木慶,中野旬之,井上和也,山本佳代子,溝渕祥,植野高章
    • Organizer
      第64回日本口腔外科学会総会・学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 歯科インプラント安定指数(ISQ値)変化に影響を与える要素の検討2019

    • Author(s)
      松本佳輔,井上和也,中島世市郎,山本佳代子,今川尚子,植野高章
    • Organizer
      第49回日本口腔インプラント学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Mechanical properties of titanium-enriched glass ionomer cement2019

    • Author(s)
      Yamamoto K, Palma-Dibb RG, Ueno T, Manso AP, Carvalho RM
    • Organizer
      The 97th International Association for Dental Research General Session
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical Evaluation of Titanium Mesh Prepared Using Selective Laser Melting Technique (Additive Manufacturing) for Alveolar Ridge Augmentation2018

    • Author(s)
      Ochi Ayako, Kato-Kogoe Nahoko, Yamamoto Kayoko, Inoue Kazuya, Inui Shihoko, Ueno Takaaki
    • Organizer
      24th European Association for Cranio-Maxillo-Facial Surgery
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bone Augmentation Performed with SLM Titanium Mesh: A Case Report2018

    • Author(s)
      Ochi Ayako, Kato-Kogoe Nahoko, Yamamoto Kayoko, Inoue Kazuya, Inui Shihoko, Ueno Takaaki
    • Organizer
      24th European Association for Cranio-Maxillo-Facial Surgery
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] iological Safety of SLM Titanium Mesh2018

    • Author(s)
      Inui Shihoko, Kato-Kogoe Nahoko, Yamamoto Kayoko, Inoue Kazuya, Ueno Takaaki, Ochi Ayako
    • Organizer
      24th European Association for Cranio-Maxillo-Facial Surgery
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 積層造形チタン人口骨を用いた骨形成過程の観察2018

    • Author(s)
      松本佳輔、中野旬之、中島世市郎、井上和也、小越菜保子、山本佳代子、越智文子、今川尚子、植野高章
    • Organizer
      第22回公益社団法人日本顎顔面インプラント学会総会・学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 選択的レーザー溶融技術(Selective Laser Melting = SLM法)を用いて作製したチタンメッシュの臨床使用経験2018

    • Author(s)
      越智文子、小越菜保子、山本佳代子、井上和也、乾志帆子、植野高章
    • Organizer
      第22回公益社団法人日本顎顔面インプラント学会総会・学術大会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi