| Project/Area Number |
18K17200
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | OSCC / EMT / microRNA / miR-205 / ZEB / p63 / ΔNp63 / ZEB1 / ZEB2 / ΔNp63β / miRNA / cancer |
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| Outline of Final Research Achievements |
Recently, epitherial-mesenchymal transition (EMT) plays an important role in the process of invasion and metastasis of cancer. We have shown that EMT is induced by ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma (OSCC). Furthermore, recent findings suggest that microRNA (miRNA) is involved in the molecular mechanism. We found that miR-205 plays an important role downstream of ΔNp63 and regulates its expression by targeting mesenchymal markers such as ZEB1 and ZEB2, which are associated with EMT.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は口腔扁平上皮癌における浸潤・転移の分子メカニズムの一部にΔNp63と関連してmicroRNA（miR-205）が関与している可能性を示した。癌の転移は生命予後を左右する重要な要素で有り、口腔癌においても頸部リンパ節転移や他臓器への遠隔転移は予後に大きく関与し、やはりその制御は未だ十分ではない。本研究のように癌の浸潤・転移の分子メカニズムを部分的にでも明らかにしていくことにより、新たな標的として治療方法を確立することで、口腔癌の治療成績のさらなる向上へ役立てることが出来ると考えている。
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