| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
After transplanting carbonated hydroxyapatite into cleft palate rats, CT imaging was performed as a radiological evaluation before transplantation, and at 4, 8, 12, and 16 weeks after transplantation.It was difficult to distinguish because the CT values of the mother bone and the transplanted materials were almost same to each other. As a method for evaluating new bone, the number of osteoclasts and osteoblasts were counted by histological evaluation by HE staining, TRAP staining, and ALP staining, and the timing of bone metabolism was examined. The number of osteoclasts and osteoblasts was significantly higher at 16 weeks than at 12 weeks after transplantation. Based on the above, it was considered that bone glue modeling is performed gently after transplantation, mild bone metabolism can be expected without excessive absorption of the mother bone of the transplantation area, and transplantation to the cleft bone defect of the jaw is effective.
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