| Project/Area Number |
18K17224
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Okayama University |
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Principal Investigator |
Kawai Hotaka 岡山大学, 医歯薬学域, 助教 (10803687)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔扁平上皮癌 / 腫瘍微小環境 / 前転移niche / 転移niche / 骨髄由来細胞 / 癌微小環境 / 口腔癌 / 扁平上皮癌 / 遠隔転移 / GFP骨髄移植マウス / 動物モデル |
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| Outline of Final Research Achievements |
When tumors metastasize to distant organs, the ease of metastasis varies from organ to organ. In recent years, it has become clear that this difference is related to a microenvironment called the "pre-metastatic niche. The "pre-metastatic niche" is a microenvironment formed in remote organs under the influence of tumors, and tumor metastasis is established using this microenvironment as a foothold.
In this study, we examined the properties of bone marrow-derived cells in high-metastasis and low-metastasis organs by using tumor-transplanted mice with good tumor growth and mice with poor tumor growth. The results showed that Arginase1-positive MDSCs were more abundant in high metastatic organs and were involved in the formation of metastatic niche.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでの研究により、肺癌や肝臓癌、大腸癌、卵巣癌などにおいて前転移nicheが形成されているとの報告があるが、本研究の結果により、口腔癌においても一部遠隔臓器で自身の免疫応答を抑制しながら前転移nicheを形成し、腫瘍の転移を促進していることが明らかとなった。したがって、口腔癌において前転移niche形成を抑制することで、腫瘍の転移を事前に制御することが可能になると考える。
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