Elucidation of tooth movement mechanism by the sympathetic nervous system via bone cells

• Project/Area Number: 18K17272
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Aichi Gakuin University
• Principal Investigator: Sato Takuma 愛知学院大学, 歯学部, 講師 (80609868)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 骨細胞 / 歯の移動 / 交感神経 / 骨代謝 / β-遮断薬 / 歯周病 / 骨吸収 / 骨量 / 歯科矯正学

Outline of Final Research Achievements

The purpose of this study was to elucidate the mechanism of tooth movement by the sympathetic nervous system via osteoocytes and to investigate the application of β-adrenergic receptor (AR) blockers as new therapeutic agents for periodontal disease. β-AR blockers decreased tooth movement and downregulated Sclerostin and RANKL in osteocytes.In addition, β2-AR blockers may be effective in preventing periodontitis.

Academic Significance and Societal Importance of the Research Achievements

本研究より、歯の移動時において、交感神経系が骨細胞からのスクレロスチンおよびRANKLの産生に関与しており、交感神経系は骨細胞を介して歯槽骨代謝の骨吸収を調節している可能性が示された。また歯周病モデルラットにおいて、β2-AR遮断薬による歯周病予防効果が認められた。将来的な歯周病予防薬としてβ2-AR遮断薬が一つの候補になる可能性が示された。

Research Products

• [Journal Article] Effects of a β2-adrenergic receptor blocker on experimental periodontitis in spontaneously hypertensive rats (2021)
  • Author(s): Atsushi Takeguchi, Ken Miyazawa, Takuma Sato, Masako Tabuchi, Ryujiro Muramatsu, Hatsuhiko Maeda, Akifumi Togari, and Shigemi Goto
  • Journal Title: Life Sciences Volume: -
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Suppression of tooth movement-induced sclerostin expression using β-adrenergic receptor blockers (2020)
  • Author(s): Shiho Uchibori, Takeo Sekiya, Takuma Sato, Kaori Hayashi, Atsushi Takeguchi, Ryujiro Muramatsu, Kyoko Ishizuka, Hisataka Kondo, Ken Miyazawa, Akifumi Togari, Shigemi Goto
  • Journal Title: Oral Diseases Volume: 26 Issue: 3 Pages: 621-629
  • DOI: 10.1111/odi.13280
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sympathicotonia-exacerbated periodontitis in a new experimental periodontitis rat model (2019)
  • Author(s): Atsushi Takeguchi, Takeyo Sekiya, Takuma Sato, Ryujiro Muramatsu, Ken Miyazawa, Hatsuhiko Maeda, Akifumi Togari, Shigemi Goto
  • Journal Title: Aichi-Gakuin dental science Volume: 32 Pages: 15-21
  • Peer Reviewed
• [Presentation] β2-アドレナリン受容体遮断は実験的歯周炎モデルラットにおいて歯周炎を予防する (2019)
  • Author(s): 竹口敦士，佐藤琢麻，村松隆二郎，宮澤健，後藤滋巳
  • Organizer: 第78回日本矯正歯科学会学術大会
• [Presentation] Effects of β-blocker on osteocyte during tooth movement (2018)
  • Author(s): 佐藤琢麻, 宮澤健, 内堀志保, 林香里, 竹口敦士, 近藤久貴, 戸苅彰史, 後藤滋巳
  • Organizer: The Korean Association of Orthodontists The 51st Annual Scientific Congress
  • Int'l Joint Research