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Development of "Next generation preventive drug for periodontal disease" aiming at "Health of oral microbiome"

Research Project

Project/Area Number 18K17276
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionTohoku University

Principal Investigator

Domon Hitomi  東北大学, 歯学研究科, 大学院非常勤講師 (60747145)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords歯周病関連菌 / フッ化物 / 増殖抑制 / 代謝抑制 / 増殖抑制効果 / 選択性阻害剤 / 口腔マイクロバイオームの健全化 / 阻害メカニズム
Outline of Final Research Achievements

We searched for substances that specifically inhibit the metabolism of proteins and dipeptides in periodontal disease-related bacteria, and investigated the mechanism of the inhibition.
In Pg ATCC33277T and Pg JCM8525, significant suppression of growth was observed even at low concentrations of fluoride, and growth was almost stopped. In addition, metabolome analysis showed an increase in some end products of Pg ATCC33277T and decrease in some intermediate metabolites due to low concentrations of fluoride. From these results, it seems possible to identify the metabolic steps inhibited by fluoride and their responsible enzymes.

Academic Significance and Societal Importance of the Research Achievements

食品添加物や医薬部外品として認可されている物質からPorphyromonas gingivalisの代謝阻害を介して増殖を抑制する物質としてフッ化物の可能性が得られた。その阻害メカニズムを解明し、歯周病関連菌選択性抗菌剤の提案を行うことは、口腔マイクロバイオームの健全化を念頭にしたこれからの歯周病予防に不可欠であると思われる。さらに、歯周病関連菌の選択的抑制に有効な薬剤を選択することができれば、『次代の歯周病予防薬』を開発できるのでないかと考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2020 2019

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Nitrite Production from Nitrate and Its Link with Lactate Metabolism in Oral Veillonella spp.2020

    • Author(s)
      Wicaksono Dimas Prasetianto、Washio Jumpei、Abiko Yuki、Domon Hitomi、Takahashi Nobuhiro
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 86 Issue: 20 Pages: 1-9

    • DOI

      10.1128/aem.01255-20

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] フッ化物による歯周病関連菌Porphyromonas gingivalisの増殖・代謝の抑制効果2019

    • Author(s)
      土門ひと美 鷲尾純平 安彦友希 川嶋順子 高橋信博
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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