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Development of stain-free denture using MPC polymer

Research Project

Project/Area Number 18K17296
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionShowa University

Principal Investigator

Fukunishi Miya  昭和大学, 歯学部, 兼任講師 (30783287)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsMPC / デンチャープラーク / 超高齢社会 / PMMA / バイオマテリアル / MPCポリマー / バイオフィルム / 誤嚥性肺炎
Outline of Final Research Achievements

This study focuses on the excellent biocompatibility, protein adsorption inhibition, and cell attachment inhibition of 2-methacryloyloxyethyl phosphorylcholine (MPC), an organic polymer that has been widely applied in the medical field. The purpose was to develop a denture.
In this study, we developed an MPC copolymer using camphorquinone, developed a polymer that can be used to coat the denture base with a dental irradiator in the clinical setting, confirmed the coating, tested anti-biofilm, etc. Were planned to be performed sequentially.
Although a more efficient method could be investigated by modifying the conventional coating method, a new MPC was not developed.

Academic Significance and Societal Importance of the Research Achievements

本研究で新たなMPCポリマーの開発は達成することができなかったが,より効率的なコーティング方法の検討を行うなど実施することができた.現状のコーティング方法よりもより効率的な方法が発見することができれば現在よりもより多くコーティングすることができ,多くの被験者にMPCコーティングを施工することができると考えられる.
現在の超高齢社会において義歯装着者は年々増加傾向にあり,義歯に対してそのようなコーティングを行うことができればより多くの装着者を誤嚥性肺炎等の疾患を防ぐことが可能である.その点から鑑みても本研究の社会的意義は大きいと考えられる.

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results)

  • [Journal Article] Inhibition of denture plaque deposition on complete dentures by 2-methacryloyloxyethyl phosphorylcholine polymer coating: A clinical study2018

    • Author(s)
      Ikeya K
    • Journal Title

      The Journal of Prosthetic Dentistry

      Volume: 119(1) Issue: 1 Pages: 67-74

    • DOI

      10.1016/j.prosdent.2017.02.012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

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