| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Anion gap (AG) implies the gap of unmeasured anions and cations, and it reflects homeostasis of electrolytes balance in serum. Because the associations between AG and hypertension, or mortality among general populations were reported, AG is used to evaluate such disease risk. However, in the evaluation, effects of other electrolytes not used in a calculation of AG were not considered well. Therefore, thorough a general population-based cohort study, I evaluated the associations between improved AG and kinds of values about blood pressure and arteriosclerosis, under taking effects of all measured electrolytes into consideration. In the result of this evaluations, improved AG is associated with cardiovascular characteristics independent of sex, age, BMI, eGFR, drug taking
and lifestyles. Besides, an electrolyte can associate with a cardiovascular characteristic independent of other electrolytes. These results contribute to elucidate a linkage among AG, electrolytes, and diseases.
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