| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Various pathological conditions of shock exhibit a peripheral circulatory failure. Focus was placed on the action of ethanol regarding the hyperdynamic circulation of superior mesenteric arteries (SMAs) occurring in warm shock, which is the earliest symptom of endotoxin shock. Vascular rings isolated from rat SMAs were showed the transient contraction by interleukin (IL)-1β was added at the top of peak contraction. Transient contraction in chronic ethanol-fed rats was further increased compared to that in the control group. In both the control and chronic ethanol-fed groups, transient contraction via IL-1β was suppressed by thromboxane A2 receptor antagonist.
Ethanol enhanced the transient contraction by IL-1β exposure and suppressed subsequent relaxation. Ethanol might have a protective effect on vessels in endotoxin shock.
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