| Project/Area Number |
18K17358
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | Tokyo Medical University (2021)
St. Luke's International University (2018-2020) |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ノロウイルス / 不顕性感染 / 前向きコホート / 追跡調査 |
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| Outline of Final Research Achievements |
This prospective age- and sex-matched cohort study included apparently healthy asymptomatic adults with a positive norovirus result and those with a negative result (ratio 1:3) during the 2016 to 2017 screening. The primary outcome was real-time reverse-transcription polymerase chain reaction-confirmed norovirus in stool specimens. Of 288 participants, 73 were positive for norovirus previously, while 215 were negative. After a median of 599 days between baseline screening and follow-up, 14 tested positive for norovirus (2.7% and 5.6% among positive- and negative-norovirus groups at baseline, respectively). Among previously norovirus-negative participants, being older, having elevated blood pressure and hemoglobin A1c level, and drinking Japanese sake at baseline were associated with positive results at follow-up. There may be higher risks of future asymptomatic norovirus infection in previously no-norovirus asymptomatic infection people with specific lifestyles or medical histories.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、健常者を対象としたノロウイルス不顕性感染の前向き研究として、最大規模であり他に類を見ないものである。現在までの研究は横断研究が主であり、現在の感染を評価するのみであった。しかしながら本研究は前向き研究であり、過去に不顕性感染を起こしたものと、起こしていないものの双方の感染のリスクを評価した点でユニークである。
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