Postural hypertension and cardiovascular disease/dementia: Hisayama Study

• Project/Area Number: 18K17382
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Kyushu University
• Principal Investigator: Sakata Satoko 九州大学, 医学研究院, 助教 (50815016)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 血圧変動 / 認知症 / 心血管病

Outline of Final Research Achievements

(1) Association of postural hypertension with the development of dementia: Using 17-year follow-up data of this cohort, we investigated the association of postural hypertension with the risk of dementia. Supine hypertension and both postural hypertension were significant and independent risk factors for dementia.
(2) Association of postural hypertension with the development of cardiovascular disease: Using 24-year follow-up data of this cohort, we investigated the association of postural hypertension with the risk of cardiovascular disease. Supine hypertension and both postural hypertension were significant and independent risk factors for cardiovascular disease.

Academic Significance and Societal Importance of the Research Achievements

精度の高い久山町の前向きコホート研究の成績をもとに、体位による血圧変動と認知症、心血管病との関連について明らかにし、臥位での血圧測定の有用性が示唆された。これは、認知症、心血管病の病態解明やその予防対策の一助になると考えられ、ひいては国民の保険・医療・福祉の向上につながることが期待される。

Research Products

• [Journal Article] Serum Lipopolysaccharide‐Binding Protein Levels and the Incidence of Cardiovascular Disease in a General Japanese Population: The Hisayama Study (2019)
  • Author(s): Asada Masako、Oishi Emi、Sakata Satoko、Hata Jun、Yoshida Daigo、Honda Takanori、Furuta Yoshihiko、Shibata Mao、Suzuki Kosuke、Watanabe Hiroshi、Murayama Norihito、Kitazono Takanari、Yamaura Ken、Ninomiya Toshiharu
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 21
  • DOI: 10.1161/jaha.119.013628
  • Peer Reviewed / Open Access
• [Journal Article] Serum elaidic acid concentration and risk of dementia (2019)
  • Author(s): Honda Takanori、Ohara Tomoyuki、Shinohara Masakazu、Hata Jun、Toh Ryuji、Yoshida Daigo、Shibata Mao、Ishida Tatsuro、Hirakawa Yoichiro、Irino Yasuhiro、Sakata Satoko、Uchida Kazuhiro、Kitazono Takanari、Kanba Shigenobu、Hirata Ken-Ichi、Ninomiya Toshiharu
  • Journal Title: Neurology Volume: 93 Issue: 22
  • DOI: 10.1212/wnl.0000000000008464
  • Peer Reviewed
• [Journal Article] NT‐proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study (2019)
  • Author(s): Nagata Takuya、Ohara Tomoyuki、Hata Jun、Sakata Satoko、Furuta Yoshihiko、Yoshida Daigo、Honda Takanori、Hirakawa Yoichiro、Ide Tomomi、Kanba Shigenobu、Kitazono Takanari、Tsutsui Hiroyuki、Ninomiya Toshiharu
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 17
  • DOI: 10.1161/jaha.118.011652
  • Peer Reviewed / Open Access
• [Journal Article] Association Between Serum β-Alanine and Risk of Dementia (2019)
  • Author(s): Hata Jun、Ohara Tomoyuki、Katakura Yoshinori、Shimizu Kuniyoshi、Yamashita Shuntaro、Yoshida Daigo、Honda Takanori、Hirakawa Yoichiro、Shibata Mao、Sakata Satoko、Kitazono Takanari、Kuhara Satoru、Ninomiya Toshiharu
  • Journal Title: American Journal of Epidemiology Volume: 188 Issue: 9 Pages: 1637-1645
  • DOI: 10.1093/aje/kwz116
  • Peer Reviewed
• [Journal Article] Serum Ethylamine Levels as an Indicator of l-Theanine Consumption and the Risk of Type 2 Diabetes in a General Japanese Population: The Hisayama Study (2019)
  • Author(s): Ninomiya Toshiharu、Kanzaki Noriyuki、Hirakawa Yoichiro、Yoshinari Masahito、Higashioka Mayu、Honda Takanori、Shibata Mao、Sakata Satoko、Yoshida Daigo、Teramoto Takanori、Takemoto Susumu、Nishimoto Shozo、Hata Jun、Kitazono Takanari
  • Journal Title: Diabetes Care Volume: 42 Issue: 7 Pages: 1234-1240
  • DOI: 10.2337/dc18-2655
  • Peer Reviewed
• [Journal Article] Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: The Hisayama Study (2018)
  • Author(s): Honda Takanori、Yoshida Daigo、Hata Jun、Hirakawa Yoichiro、Ishida Yuki、Shibata Mao、Sakata Satoko、Kitazono Takanari、Ninomiya Toshiharu
  • Journal Title: Atherosclerosis Volume: 279 Pages: 38-44
  • DOI: 10.1016/j.atherosclerosis.2018.10.014
  • Peer Reviewed
• [Journal Article] Impact of obstructive sleep apnea on long-term blood pressure variability in Japanese men: a cross-sectional study of a work-site population (2018)
  • Author(s): Kansui Yasuo、Matsumura Kiyoshi、Morinaga Yuki、Inoue Minako、Sakata Satoko、Oishi Emi、Goto Kenichi、Ohtsubo Toshio、Ooboshi Hiroaki、Kitazono Takanari
  • Journal Title: Hypertension Research Volume: 41 Issue: 11 Pages: 957-964
  • DOI: 10.1038/s41440-018-0096-3
  • Peer Reviewed
• [Presentation] 地域高齢住民における臥位高血圧と認知症発症の関連：久山町研究 (2018)
  • Author(s): 坂田智子、大石絵美、小原知之、秦淳、大坪俊夫、北園孝成、二宮利治
  • Organizer: 第41回日本高血圧学会総会