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The effects of frailty and sarcopenia on the incident of disability and prognosis.

Research Project

Project/Area Number 18K17393
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

Hideaki Ishii  国立研究開発法人国立長寿医療研究センター, 老年学・社会科学研究センター, 研究員 (50751046)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsフレイル / サルコペニア / 予後 / 新規要介護発生 / 介護保険 / 要介護発生 / 地域在住高齢者
Outline of Final Research Achievements

This purpose of study was to examine the similarities and differences between frailty and sarcopenia on the incident disability, costs for long-term care and mortality. The result showed that frailty and sarcopenia were associated with incident disability, costs for long-term care and mortality, respectively. In addition, the participants were divided into four groups: sarcopenia group, frailty group, group with overlapping sarcopenia and frailty (overlap group), and robust group. As a result, the risk of incident disability, death and costs for long-term care were higher in the overlap group. In addition, the frailty group had a higher risk of incident disability and higher costs for long-term care than the sarcopenia group.

Academic Significance and Societal Importance of the Research Achievements

本研究より、フレイルとサルコペニアは新規要介護発生や予後に関連するが、フレイルはサルコペニアより新規要介護発生のリスクや介護給付費に影響する可能性があると考えられる。また、フレイルとサルコペニアを有する高齢者は、要介護だけでなく死亡率にも影響することが明らかとなった。以上のことより、フレイルはサルコペニアより新規要介護発生や介護給付費に対する影響が大きいが、両方を有する高齢者はそれぞれ単独で有する高齢者よりも死亡に対するリスクが高いため、併用してスクリーニングしていく必要があると考えられる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (15 results)

All 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (9 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Association between Anorexia of Aging and Sarcopenia among Japanese Older Adults2020

    • Author(s)
      Tsutsumimoto K, Doi T, Nakakubo S, Kim M, Kurita S, Ishii H, Shimada H
    • Journal Title

      J Cachexia Sarcopeni

      Volume: Epub ahead of print Issue: 5 Pages: 1250-1257

    • DOI

      10.1002/jcsm.12571

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictivity of bioimpedance phase angle for incident disability in older adults2020

    • Author(s)
      Uemura K, Doi T, Tsutsumimoto K, Nakakubo S, Kim MJ, Kurita S, Ishii H, Shimada H
    • Journal Title

      J Cachexia Sarcopenia Muscle

      Volume: 11 Issue: 1 Pages: 46-54

    • DOI

      10.1002/jcsm.12492

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of comorbid physical frailty and low muscle mass on incident disability in community-dwelling older adults: A 24-month follow-up longitudinal study.2020

    • Author(s)
      Ishii Hideaki, Tsutsumimoto Kota, Doi Takehiko, Nakakubo Sho, Kim Min-ji, Kurita Satoshi, Shimada Hiroyuki
    • Journal Title

      Maturitas

      Volume: ー

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatio-temporal gait variables predicted incident disability2020

    • Author(s)
      Doi T, Nakakubo S, Tsutsumimoto K, Kim M, Kurita S, Ishii H, Shimada H
    • Journal Title

      J Neuroeng Rehabil

      Volume: 17 Issue: 1 Pages: 11-11

    • DOI

      10.1186/s12984-020-0643-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations of Skeletal Muscle Mass, Lower-Extremity Functioning, and Cognitive Impairment in Community-Dwelling Older People in Japan2018

    • Author(s)
      Ishii Hideaki、Makizako H.、Doi T.、Tsutsumimoto K.、Shimada H.
    • Journal Title

      The journal of nutrition, health & aging

      Volume: 23 Issue: 1 Pages: 35-41

    • DOI

      10.1007/s12603-018-1110-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of sarcopenia and its association with activities of daily living among japanese nursing home residents2018

    • Author(s)
      Kamo Tomohiko、Ishii Hideaki、Suzuki Keisuke、Nishida Yuusuke
    • Journal Title

      Geriatric Nursing

      Volume: 39 Issue: 5 Pages: 528-533

    • DOI

      10.1016/j.gerinurse.2018.02.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Association between Anorexia of Aging and Sarcopenia among Japanese Older Adults.2020

    • Author(s)
      Tsutsumimoto K, Doi T, Nakakubo S, Kurita S, Ishii H, Shimada H
    • Organizer
      International Conference on Frailty and Sarcopenia Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域在住高齢者における下肢機能の低下と多領域の認知障害の関連.2019

    • Author(s)
      石井秀明, 土井剛彦, 堤本広大, 中窪翔, 金珉智, 栗田智史, 島田裕之.
    • Organizer
      第9回日本認知症予防学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 歩行能力の低下は死亡リスクの予測因子となりうるのか?2019

    • Author(s)
      土井剛彦, 中窪翔, 堤本広大, 金珉智, 栗田智史, 石井秀明, 島田裕之.
    • Organizer
      第61回日本老年医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高齢期における身体的フレイルと筋量低下の併発は,新規要介護発生に影響を与えうるのか?―2年間の縦断研究―.2019

    • Author(s)
      石井秀明, 堤本広大, 土井剛彦, 中窪翔, 金珉智, 栗田智史, 島田裕之
    • Organizer
      第61回日本老年医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高齢期の食欲低下は,フレイルを介して間接的に将来の要介護を引き起こす.2019

    • Author(s)
      堤本広大, 土井剛彦, 中窪翔, 金珉智, 栗田智史, 石井秀明, 島田裕之
    • Organizer
      第61回日本老年医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Association of Skeletal Muscle Mass and Lower-Extremity Functioning with Cognitive Impairment in Community-Dwelling Older People in Japan2018

    • Author(s)
      Ishii H, Makizako H Doi T Tsutsumimoto K Shimada H.
    • Organizer
      ACPT Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spatio-Temporal Gait Variables Related to Disability.2018

    • Author(s)
      Doi T, Nakakubo S, Tsutsumimoto K, Kim M, Kurita S, Ishii H, Shimada H.
    • Organizer
      ACPT Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Associations Between Skeletal Muscle Mass Index and Walking Parameters in Japanese Older Adults.2018

    • Author(s)
      Shimada H, Doi T, Lee S, Bae S, Nakakubo S, Ishii H.
    • Organizer
      ACPT Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rate of torque development and maximal torque production in elderly fallers and non-fallers.2018

    • Author(s)
      Kamo T, Ogihara H, Ikeda T, Asahi R, Azami M, Suzuki K, Ishii H, Nishida Y.
    • Organizer
      ACPT Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2021-02-19  

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