Multifaceted investigation of screening method on postprandial hyperglycemia and hypertension based on self-measured home blood pressure

• Project/Area Number: 18K17396
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Teikyo University
• Principal Investigator: Tatsumi Ykako 帝京大学, 医学部, 講師 (00757685)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 家庭血圧 / 食後血糖 / 血圧コントロール / 食後高血糖 / 家庭血圧測定 / 健康診断 / 糖尿病 / 高血圧 / スクリーニング

Outline of Final Research Achievements

Postprandial hyperglycaemia: a glucose tolerance test using fingertip peripheral blood glucose measurement was planned as a demonstration of the simple glucose tolerance test, but due to the COVID19 epidemic, the test could not be carried out. However, during the study period, the plan was switched to a simplified glucose tolerance test using a less invasive and painless blood glucose estimation method using Flash Glucose Monitoring (FGM) instead of fingertip peripheral blood sampling, and the feasibility of FGM is being examined.
Home hypertension：The results of a large-scale questionnaire survey on home blood pressure measurement were published, analysing the characteristics of those who usually measured home blood pressure and the association between measuring home blood pressure and blood pressure control among a working population.
The association between postprandial hyperglycaemia and home hypertension was analysed using a cohort study.

Academic Significance and Societal Importance of the Research Achievements

食後高血糖は、通常の採血で測定できる空腹時高血糖やヘモグロビンA1cからは発見しにくいため、糖分を摂取した後の血糖測定が非常に重要である。現代の標準的な方法では被験者の苦痛が大きいため、出来るだけ侵襲や痛みを伴わず、簡易的に食後高血糖を測定することは非常に重要である。
家庭血圧は将来の脳心血管疾患を予防するために非常に重要であるが、高血圧の治療を受けていても測定が習慣化している者とそうでない者がいる。習慣化していない者に測定を促すためには対象者の傾向を理解し、家庭血圧を測定することが血圧コントロールにつながることを証明し、その利点を対象者に示すことが重要である。

Research Products

• [Journal Article] Association between urinary sodium-to-potassium ratio and home blood pressure and ambulatory blood pressure: the Ohasama study (2022)
  • Author(s): Muroya Tomoko、Satoh Michihiro、Murakami Takahisa、Nakayama Shingo、Asayama Kei、Hirose Takuo、Tatsumi Yukako、Inoue Ryusuke、Tsubota-Utsugi Megumi、Hara Azusa、Kogure Mana、Nakaya Naoki、Nomura Kyoko、Kikuya Masahiro、Metoki Hirohito、Imai Yutaka、Hozawa Atsushi、Ohkubo Takayoshi
  • Journal Title: Journal of Hypertension Volume: 40 Issue: 5 Pages: 862-869
  • DOI: 10.1097/hjh.0000000000003087
  • Peer Reviewed / Open Access
• [Journal Article] Current status of home blood pressure measurement and relevant demographics and lifestyle characteristics of individuals with periodic measurement: a cross-sectional study in a worksite population (2021)
  • Author(s): 辰巳友佳子、志摩梓、川村敦子、森野亜弓、河津雄一郎、大久保孝義
  • Journal Title: SANGYO EISEIGAKU ZASSHI Volume: 63 Issue: 2 Pages: 43-52
  • DOI: 10.1539/sangyoeisei.2020-016-B
  • NAID: 130008002696
  • ISSN: 1341-0725, 1349-533X
  • Year and Date: 2021-03-20
  • Peer Reviewed / Open Access
• [Journal Article] Prediction Models for the 5- and 10-Year Incidence of Home Morning Hypertension: The Ohasama Study (2021)
  • Author(s): Satoh Michihiro、Metoki Hirohito、Asayama Kei、Kikuya Masahiro、Murakami Takahisa、Tatsumi Yukako、Hara Azusa、Tsubota-Utsugi Megumi、Hirose Takuo、Inoue Ryusuke、Nomura Kyoko、Hozawa Atsushi、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: American Journal of Hypertension Volume: 35 Issue: 4 Pages: 328-336
  • DOI: 10.1093/ajh/hpab177
  • Peer Reviewed / Open Access
• [Journal Article] Cluster-randomized controlled trial for the early promotion of clinic visits for untreated hypertension (2020)
  • Author(s): 1.Shima A, Arima H, Miura K, Tatsumi Y, Ohkubo T, Kawatsu T, Morino A, Kimura T, Godai K, Azuma S, Miyamatsu N.
  • Journal Title: Hypertension research Volume: 44(3) Issue: 3 Pages: 355-362
  • DOI: 10.1038/s41440-020-00559-0
  • Peer Reviewed
• [Journal Article] Recent status of self-measured home blood pressure in the Japanese general population: a modern database on self-measured home blood pressure (MDAS) (2020)
  • Author(s): Asayama Kei、Tabara Yasuharu、Oishi Emi、Sakata Satoko、Hisamatsu Takashi、Godai Kayo、Kabayama Mai、Tatsumi Yukako、Hata Jun、Kikuya Masahiro、Kamide Kei、Miura Katsuyuki、Ninomiya Toshiharu、Ohkubo Takayoshi
  • Journal Title: Hypertension Research Volume: 43 Issue: 12 Pages: 1403-1412
  • DOI: 10.1038/s41440-020-0530-1
  • Peer Reviewed
• [Journal Article] Hyperuricemia predicts the risk for developing hypertension independent of alcohol drinking status in men and women: the Saku study. (2020)
  • Author(s): Tatsumi Y, Asayama K, Morimoto A, Satoh M, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T.
  • Journal Title: Hypertension Research Volume: 43 Issue: 5 Pages: 442-449
  • DOI: 10.1038/s41440-019-0361-0
  • Peer Reviewed
• [Journal Article] 大規模健診時血圧データに基づく加齢に伴う血圧推移に関する縦断解析 (2020)
  • Author(s): 佐藤 倫広, 村上 任尚, 小原 拓, 辰巳 友佳子, 高畠 恭介, 原 梓, 浅山 敬, 今井 潤, 菊谷 昌浩, 大久保 孝義, 目時 弘仁
  • Journal Title: 日本循環器病予防学会誌 Volume: 54 Pages: 163-170
  • Peer Reviewed
• [Journal Article] Fasting Blood Glucose Predicts Incidence of Hypertension Independent of HbA1c Levels and Insulin Resistance in Middle-Aged Japanese: The Saku Study. (2019)
  • Author(s): Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T.
  • Journal Title: American Journal of Hypertension Volume: 32 Issue: 12 Pages: 1178-1185
  • DOI: 10.1093/ajh/hpz123
  • Peer Reviewed
• [Journal Article] Risk of developing type 2 diabetes according to blood pressure levels and presence or absence of hypertensive treatment: the Saku study. (2019)
  • Author(s): Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T
  • Journal Title: Hypertension Research Volume: 42 Issue: 1 Pages: 105-113
  • DOI: 10.1038/s41440-018-0121-6
  • Peer Reviewed
• [Presentation] 降圧治療中の労働者における家庭血圧測定実施と健診時血圧コントロール状況との関連: 服薬開始時期を考慮した検討 (2021)
  • Author(s): 辰巳友佳子, 志摩梓, 川村敦子, 森野亜弓, 河津雄一郎, 宮松直美, 大久保孝義
  • Organizer: 第57回日本循環器病予防学会学術集会
• [Presentation] High fasting blood glucose levels increase risk of hypertension incidence independent insulin resistance in Japanese: The Saku study (2021)
  • Author(s): Yukako Tatsumi, Kei Asayama, Akiko Morimoto, Nao Sonoda, Naomi Miyamatsu, Yuko Ohno, Yoshihiro Miyamoto, Satoshi Izawa, Takayoshi Ohkubo
  • Organizer: Joint meeting ESH-ISH 2020
  • Int'l Joint Research
• [Presentation] High fasting blood glucose level increase risk of hypertension incidence independent insulin resistance in Japanese: The Saku study (2021)
  • Author(s): Yukako Tatsumi, Kei Asayama, Akiko Morimoto, Nao Sonoda, Naomi Miyamatsu, Yuko Ohno, Yoshihiro Miyamoto, Satoshi Izawa, Takayoshi Ohkubo
  • Organizer: JOINT MEETIN ESH-ISH2021
  • Int'l Joint Research
• [Presentation] Association between hyperuricemia and hypertension among non-drinkers: Japanese prospective cohort study (2019)
  • Author(s): Yukako Tatsumi, Kei Asayama, Akiko Morimoto, Michihiro Satoh, Nao Sonoda, Naomi Miyamatsu, Yuko Ohno, Yoshihiro Miyamoto, Satoshi Izawa, Takayoshi Ohkubo
  • Organizer: 29th European Meeting on Hypertension and Cardiovascular Protection
  • Int'l Joint Research
• [Presentation] 降圧剤服用の有無およびJSH2019診察室血圧分類と家庭血圧測定実施率の関連：職域横断研究 (2019)
  • Author(s): 辰巳友佳子、志摩梓、宮松直美、大久保孝義
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] 未治療高血圧者への健診現場における即日の紹介状発行が外来受診率向上に及ぼす効果 (2019)
  • Author(s): 志摩梓、有馬久富、三浦克之、辰巳友佳子、大久保孝義、呉代華容、木村隆、宮松直美
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] Age-related trends in blood pressure based on large-scale health checkup data using longitudinal analysis (2019)
  • Author(s): Michihiro Satoh, Takahisa Murakami, Taku Obara, Yukako Tatsumi, Kyosuke Takabatake, Azusa Hara, Kei Asayama, Yutaka Imai, Masahiro Kikuya, Takayoshi Ohkubo, Hirohito Metoki
  • Organizer: 29th European Meeting on Hypertension and Cardiovascular Protection
  • Int'l Joint Research
• [Presentation] 肥満の有無による高血圧と糖尿病発症リスクとの関連：佐久研究 (2018)
  • Author(s): 辰巳友佳子、浅山敬、宮松直美、宮本恵宏、大久保孝義
  • Organizer: 日本高血圧学会
• [Presentation] Risk of developing type 2 diabetes according to blood pressure levels and presence or absence of hypertensive treatment: the Saku study (2018)
  • Author(s): Yukako Tatsumi, Akiko Morimoto, Kei Asayama, Nao Sonoda, Naomi Miyamatsu, Yuko Ohno, Yoshihiro Miyamoto, Satoshi Izawa, Takayoshi Ohkubo
  • Organizer: 欧州高血圧学会
  • Int'l Joint Research
• [Presentation] 血糖およびインスリン作用と高血圧発症との関連：佐久研究 (2018)
  • Author(s): 辰巳友佳子、森本明子、浅山敬、園田奈央、宮松直美、大野ゆう子、宮本恵宏、伊澤敏、大久保孝義
  • Organizer: 日本循環器病予防学会