Association of frailty Trajectories with Medical and Long-Term Care Costs

• Project/Area Number: 18K17409
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: National Institute for Environmental Studies (2019); Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2018)
• Principal Investigator: Taniguchi Yu 国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 主任研究員 (40636578)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: frailty score / trajectory / 類型化 / 死亡リスク / 医療費 / 介護費 / Frailty / 加齢変化パターン / 社会保障費 / フレイル / frailty

Outline of Final Research Achievements

Using up to 12 years of repeated-measures data, we identified aging trajectories for an index in frailty score among older Japanese and examined whether these trajectories were associated with all-cause mortality and healthcare costs. The total number of observations was 6373. Frailty was defined by criteria from Fried’s phenotype. We identified four aging trajectories for frailty. Specifically, 6.5%, 47.3%, 30.3%, and 16.0% of participants were in the high, second, third, and low trajectory groups, respectively. As compared with the low trajectory group, the high trajectory group had greater risks of death. Medical and long-term care costs greatly increased after age 80 years in the second and third trajectory groups. Medical and care needs greatly increased for the second and third trajectory groups when they progressed from pre-frailty to frailty.

Academic Significance and Societal Importance of the Research Achievements

本研究から、地域在住高齢者がFrailtyに至るプロセスには異なるパターンが存在することが明らかになり、後期高齢期にpre-frailtyの状態を経てFrailtyに至る47.3%の集団や後期高齢期にrobustからpre-frailtyに至る30.3%の集団が特定された。後期高齢期にpre-frailtyやFrailtyに至る集団の死亡リスク及び社会保障費の上昇が明らかになったことから、地域在住高齢者に対する健康増進施策において、後期高齢期のFrailty及びpre-frailty対策を推進することにより、高齢者本人の健康長寿と我が国の社会保障費の安定に寄与できる可能性が示唆された。

Research Products

• [Journal Article] Trajectories of kidney function and associated factors among community dwelling older Japanese: a 16 year longitudinal study (2020)
  • Author(s): Kaito Sho, Taniguchi Yu , Kitamura Akihiko, Seino Satoshi, Amano Hidenori, Yokoyama Yuri, Fukuda Hiroshi, Yokokawa Hirohide, Fujiwara Yoshinori, Shinkai Shoji, Naito Toshio
  • Journal Title: Clinical and Experimental Nephrology Volume: 24 Issue: 4 Pages: 330-338
  • DOI: 10.1007/s10157-019-01837-z
  • Peer Reviewed
• [Journal Article] Association of trajectories of cognitive function with cause‐specific mortality and medical and long‐term care costs (2019)
  • Author(s): Taniguchi Yu、Kitamura Akihiko、Ishizaki Tatsuro、Fujiwara Yoshinori、Shinozaki Tomohiro、Seino Satoshi、Mitsutake Seigo、Suzuki Hiroyuki、Yokoyama Yuri、Abe Takumi、Ikeuchi Tomoko、Yokota Isao、Matsuyama Yutaka、Shinkai Shoji
  • Journal Title: Geriatrics & Gerontology International Volume: 19 Issue: 12 Pages: 1236-1242
  • DOI: 10.1111/ggi.13802
  • Peer Reviewed
• [Journal Article] Albumin and Hemoglobin Trajectories and Incident Disabling Dementia in Community-Dwelling Older Japanese (2019)
  • Author(s): Taniguchi Y, Kitamura A, Kaito S, Yokoyama Y, Yokota I, Shinozaki T, Seino S, Murayama H, Matsuyama Y, Ikeuchi T, Fujiwara Y, Shinkai S
  • Journal Title: Dementia and Geriatric Cognitive Disorders Volume: 47 Issue: 4-6 Pages: 233-242
  • DOI: 10.1159/000499837
  • Peer Reviewed
• [Journal Article] Characteristics for Gait Parameters of Community-Dwelling Elderly Japanese with Lower Cognitive Function (2019)
  • Author(s): Yu Taniguchi, Yutaka Watanabe, Yosuke Osuka, Akihiko Kitamura, Satoshi Seino, Hunkyun Kim, Hisashi Kawai, Ryota Sakurai, Hiroki Inagaki, Shuichi Awata, Shoji Shinkai.
  • Journal Title: Plos One Volume: 27 Issue: 3 Pages: 0-0
  • DOI: 10.1371/journal.pone.0212646
  • Peer Reviewed / Open Access
• [Journal Article] Combined effect of diabetes and frailty on mortality and incident disability in older Japanese adults. (2019)
  • Author(s): Akihiko Kitamura, Yu Taniguchi, Satoshi Seino, Yuri Yokoyama, Hidenori Amano, Yoshinori Fujiwara, Shoji Shinkai.
  • Journal Title: Geriatrics & Gerontology International Volume: 印刷中 Issue: 5 Pages: 423-428
  • DOI: 10.1111/ggi.13637
  • Peer Reviewed / Open Access
• [Journal Article] Albumin and Hemoglobin Trajectories and Incident Disabling Dementia in Community-Dwelling Older Japanese. (2019)
  • Author(s): Yu Taniguchi, Akihiko Kitamura, Sho Kaito, Yuri Yokoyama, Isao Yokota, Tomohiro Shinozaki, Satoshi Seino, Hiroshi Murayama, Yutaka Matsuyama, Tomoko Ikeuchi, Yoshinori Fujiwara, Shoji Shinkai.
  • Journal Title: Dementia and Geriatric Cognitive Disorders Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Association of Trajectories of Higher-Level Functional Capacity with Mortality and Medical and Long-Term Care Costs Among Community-Dwelling Older Japanese. (2018)
  • Author(s): Yu Taniguchi, Akihiko Kitamura, Yu Nofuji, Tatsuro Ishizaki, Satoshi Seino, Yuri Yokoyama, Tomohiro Shinozaki, Hiroshi Murayama, Seigo Mitsutake, Hidenori Amano, Mariko Nishi, Yutaka Matsuyama, Yoshinori Fujiwara, Shoji Shinkai.
  • Journal Title: The Journals of Gerontology Medical Science Volume: 16 Pages: 211-218
  • Peer Reviewed
• [Journal Article] Trajectories of Arterial Stiffness and All-Cause Mortality Among Community-Dwelling Older Japanese. (2018)
  • Author(s): Yu Taniguchi, Akihiko Kitamura, Tomohiro Shinozaki, Satoshi Seino, Yuri Yokoyama, Miki Narita, Hidenori Amano, Yutaka Matsuyama, Yoshinori Fujiwara, Shoji Shinkai.
  • Journal Title: Geriatrics & Gerontology International Volume: 18 Issue: 7 Pages: 1108-1113
  • DOI: 10.1111/ggi.13323
  • Peer Reviewed
• [Journal Article] Are the Kihon Checklist and the Kaigo-Yobo Checklist compatible with the Frailty Index? (2018)
  • Author(s): Gotaro Kojima, Yu Taniguchi, Akihiko Kitamura, Shoji Shinkai.
  • Journal Title: Journals of the American Medical Directors Association Volume: 19 Issue: 9 Pages: 797-800.e2
  • DOI: 10.1016/j.jamda.2018.05.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Physical, social, and psychological characteristics of community-dwelling elderly Japanese dog and cat owners. (2018)
  • Author(s): Yu Taniguchi, Satoshi Seino, Mariko Nishi, Yui Tomine, Izumi Tanaka, Yuri Yokoyama, Hidenori Amano, Akihiko Kitamura, Shoji Shinkai.
  • Journal Title: Plos One Volume: 14 Issue: 11 Pages: 0206399-0206399
  • DOI: 10.1371/journal.pone.0206399
  • Peer Reviewed / Open Access
• [Journal Article] Transitions between frailty states among community-dwelling older people: A systematic review and meta-analysis. (2018)
  • Author(s): Gotaro Kojima, Yu Taniguchi,Steve Iliffe, Stephen Jivraj, Kate Walters.
  • Journal Title: Ageing Research Reviews Volume: 50 Pages: 81-88
  • DOI: 10.1016/j.arr.2019.01.010
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Association of Trajectories of Cognitive Function with Cause-Specific Mortality and Medical and Long-Term Care Costs (2019)
  • Author(s): Taniguchi Yu, Kitamura Akihiko, Ishizaki Tatsuro, Fujiwara Yoshinori, Seino Satoshi, Mitsutake Seigo, Suzuki Hiroyuki, Yokoyama Yuri, Abe Takumi, Ikeuchi Tomoko, Shinkai Shoji
  • Organizer: 11th International Association of Gerontology and Geriatrics Asia/Oceania Regional
  • Int'l Joint Research
• [Presentation] 認知機能の経時的変化パターンと身体・心理・社会的機能との関連 (2019)
  • Author(s): 谷口優，北村明彦，藤原佳典，清野諭，鈴木宏幸，横山友里，天野秀紀，成田美紀，阿部巧，新開省二
  • Organizer: 第61回日本老年医学会学術集会
• [Presentation] 歩行機能の加齢変化パターンと医療費との関連 (2018)
  • Author(s): 谷口優、北村明彦、清野諭、横山友里、石崎達郎、光武誠吾、西真理子、天野秀紀、藤原佳典、新開省二
  • Organizer: 第60回日本老年医学会学術集会
• [Presentation] 地域在宅高齢者における足底圧分布プラットフォームにより計測した種々の歩行機能と認知機能との関連 (2018)
  • Author(s): 谷口優、渡邊裕、大須賀洋祐、北村明彦、清野諭、金憲経、河合恒、桜井良太、稲垣宏樹、粟田主一、新開省二．
  • Organizer: 第13回日本応用老年学会
• [Presentation] 認知機能の変化パターンと医療費及び介護費との関連－草津町研究－ (2018)
  • Author(s): 谷口優、北村明彦、石﨑達郎、清野諭、横山友里、藤原佳典、鈴木宏幸、光武誠吾、野藤悠、天野秀紀、西真理子、干川なつみ、濱口奈緒美、岡部たづる、新開省二
  • Organizer: 第77回日本公衆衛生学会総会