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Exhaustive detection of micro-ruptured cortical arteries in subdural hematoma using the tissue-clearing CUBIC (clear, unobstructed, brain/body imaging cocktails and computational analysis) method

Research Project

Project/Area Number 18K17412
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58040:Forensics medicine-related
Research InstitutionNiigata University

Principal Investigator

Funayama Kazuhisa  新潟大学, 医歯学系, 助教 (80568486)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords皮質動脈破裂による硬膜下血腫 / 組織透明化/3次元イメージング技術「CUBIC」 / 死後頭部造影CT / 皮質動脈破綻による硬膜下血腫 / 死後造影CT / 死後MRI / 死後超音波画像
Outline of Final Research Achievements

Our study demonstrated the utility of head postmortem angiographic CT for identifying cortical artery rupture sites in cases of acute subdural hematoma, successfully identifying the rupture site in over half of the cases. This technique proves to be a valuable method for reliably locating these lesions, which can be challenging to detect macroscopically.
Furthermore, our findings revealed that the CUBIC method offers superior ease of detection compared to traditional macroscopic observation. Additionally, CUBIC enables high-definition three-dimensional and two-dimensional morphological analysis equivalent to pathological tissue images, making it a valuable tool for guiding the preparation of actual pathological tissue sections and complementing pathohistological findings by synthesizing multiple hypothetical histological sections.

Academic Significance and Societal Importance of the Research Achievements

本研究によって硬膜下血腫の解剖において出血源として皮質動脈の破裂を検出し、破裂部位の詳細な病理組織学的検索を実行することが可能となった。硬膜下血腫の解剖において出血源として皮質動脈の破裂を検出し、破裂部位の詳細な病理組織学的検索を行った2症例について、1950年以来71年ぶりに症例報告を行うことができた。病理組織学的知見の蓄積が不十分なために未解明であった皮質動脈破裂の詳細な病態について、病理組織学的知見が蓄積され解明されることが期待される。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2024 2023 2022 2021 2019

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Bleeding-Source Exploration in Subdural Hematoma: Observational Study on the Usefulness of Postmortem Computed Tomography Angiography2023

    • Author(s)
      Funayama Kazuhisa、Koyama Akihide、Katsuragi-Go Rieka、Aoyama Takashi、Watanabe Hiraku、Takahashi Naoya、Takatsuka Hisakazu
    • Journal Title

      Diagnostics

      Volume: 13 Issue: 13 Pages: 2286-2286

    • DOI

      10.3390/diagnostics13132286

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 皮質動脈破裂による硬膜下血腫2023

    • Author(s)
      舟山 一寿
    • Journal Title

      新潟県医師会報

      Volume: 879 Pages: 2-6

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Detection and Morphological Analysis of Micro-Ruptured Cortical Arteries in Subdural Hematoma: Three-Dimensional Visualization Using the Tissue-Clearing Clear, Unobstructed, Brain/Body Imaging Cocktails and Computational Analysis Method2022

    • Author(s)
      Funayama K, Tainaka K, Koyama A, et al.
    • Journal Title

      Diagnostics (Basel)

      Volume: 12 Issue: 11 Pages: 2875-2875

    • DOI

      10.3390/diagnostics12112875

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The usefulness of postmortem computed tomography angiography for subdural hematoma caused by rupture of the cortical artery: A report of two autopsy cases and a literature review2021

    • Author(s)
      Funayama K, Harada K, Koyama A, Katsuragi-Go R, Nishikawa-Harada N, Higuchi R, Aoyama T, Watanabe H, Takahashi N, Takatsuka H.
    • Journal Title

      Legal medicine

      Volume: 53 Pages: 101941-101941

    • DOI

      10.1016/j.legalmed.2021.101941

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] An autopsy case of peliosis hepatis with X-linked myotubular myopathy2019

    • Author(s)
      Funayama K, Shimizu H, Tanaka H, Kawachi I, Nishino I, Matsui K, Takahashi N6, Koyama A, Katsuragi-Go R, Higuchi R, Aoyama T, Watanabe H, Kakita A, Takatsuka H.
    • Journal Title

      Legal Medicine

      Volume: 38 Pages: 77-82

    • DOI

      10.1016/j.legalmed.2019.04.005

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 硬膜下血腫における皮質動脈破裂の検出と形態解析:CUBIC法による組織透明化を用いた3次元画像化2024

    • Author(s)
      舟山 一寿、田井中 一貴、小山 哲秀、葛城 梨江香、青山 崇、渡邉 拓、髙橋 直也、高塚 尚和
    • Organizer
      第108次日本法医学会学術全国集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 死後造影CTによって皮質動脈の破裂を描出した硬膜下血腫の2剖検例2021

    • Author(s)
      舟山 一寿, 原田 一樹, 小山 哲秀, 葛城 梨江香, 西川 夏実, 樋口 涼子, 青山 崇, 渡邉 拓, 高橋 直也, 高塚 尚和
    • Organizer
      第19回Ai学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 皮質動脈破綻による硬膜下血腫の2剖検例:死後造影CTと連続切片による動脈破綻の検索2021

    • Author(s)
      舟山 一寿, 原田 一樹, 小山 哲秀, 葛城 梨江香, 西川 夏実, 樋口 涼子, 青山 崇, 渡邉 拓, 高橋 直也, 高塚 尚和
    • Organizer
      第43回日本法医学会学術中部地方集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 硬膜下血腫の出血源:剖検における皮質動脈破裂の検索2021

    • Author(s)
      舟山 一寿
    • Organizer
      第2回 ヒト剖検脳研究に関する勉強会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] An autopsy case of subacute subdural hematoma caused by tiny rupture of the cortical artery2019

    • Author(s)
      Kazuhisa Funayama
    • Organizer
      The Forth Education Center for Forensic Pathology and Science Symposium & Japan and Korea Forensic Pathology Joint Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2025-01-30  

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