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Elucidation of the Mechanism of Care Effectiveness Using Complementary and Alternative Medicine Material Detergent for Radiation Skin Damage

Research Project

Project/Area Number 18K17460
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 58050:Fundamental of nursing-related
Research InstitutionNiigata University

Principal Investigator

KAKIHARA Nahoko  新潟大学, 医歯学系, 准教授 (50588762)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords放射線皮膚障害 / 治癒促進効果 / 予防効果 / 抗酸化 / フラボノイド / ケアのエビデンス / セリシン / 予防的効果 / 修復促進効果 / 放射線看護のエビデンス / 放射線皮膚障害のケア / 看護技術開発 / 補完代替材料 / 照射性皮膚 / 治癒促進 / 自然治癒力 / 放射線看護 / 補完代替医療材料 / メカニズム解明 / 保湿
Outline of Final Research Achievements

No care has been established for skin damage caused by irradiation that is adapted to the mechanism of radiation damage. Therefore, the current situation is that the skin becomes dry, and conventional moisturizers are applied to the skin. In radiation-induced skin damage, cells Therefore, skin damage persists for a long period of time. Therefore, not only moisturizing effects but also antioxidant and cell repair effects are required for skin cells. Cocoons have been used. We found that green cocoons, which contain a large amount of flavonoids, are particularly effective.

Academic Significance and Societal Importance of the Research Achievements

放射線照射による皮膚障害に対して,そのメカニズムに適応したケアが確立していない.そのため,乾燥した皮膚になることから,これまで使われている保湿剤の塗布をしているのが現状である.放射線照射による皮膚障害では,放射線量が一定以上になと細胞の分裂死により分裂が停止する.そのため長期間にわたり皮膚障害が続く.そのため保湿効果だけでなく皮膚細胞にとっては,抗酸化作用や細胞修復効果が求められる.今回はその手掛かりとなるフラボノイドを多く含む緑繭にそれらの効果が高いことが初めて分かった.この成果により,放射線皮膚障害のケアの方法が適切になっていくための手掛かりができた.

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2021 2020

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and dramatically increases survival rates of mice.2020

    • Author(s)
      Sato M, Onuma K, Domon M, Hasegawa S, Suzuki A, Kusumi R, Hino R, Kakihara N Kanda Y, Osaki M, Hamada J, Bannai S, Feederle R, Buday K, Angeli JPF, Proneth B, Conrad M, Okada F, and Sato H.
    • Journal Title

      Int J Cancer

      Volume: 147 Issue: 11 Pages: 3224-3235

    • DOI

      10.1002/ijc.33262

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] シスチン/グルタミン酸輸送系(xc-系)の欠損が腫瘍細胞の転移に及ぼす影響2021

    • Author(s)
      佐藤茉美,小野邦重,柿原奈保子,佐藤英世,他.
    • Organizer
      第30回日本がん転移学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 放射線障害に対するフラボノイド繭抽出セリシンの皮膚防護効果・有効性についての基礎的検討~線維芽細胞を用いた実験研究~2021

    • Author(s)
      柿原奈保子,佐藤英世,佐藤茉美
    • Organizer
      第10回日本放射線看護学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 放射線照射に対する標準繭およびフラボノイド繭由来セリシンの皮膚防御効果に関する基礎的検討2021

    • Author(s)
      柿原奈保子,佐藤英世,佐藤茉美,他.
    • Organizer
      第9回看護理工学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Book] 老年看護学講義ノート2020

    • Author(s)
      小山千加代編
    • Total Pages
      140
    • Publisher
      編集工房 球
    • ISBN
      9784907951016
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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