| Project/Area Number |
18K17717
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脊髄損傷 / 機能回復 / サル / ECoG / 巧緻運動 / EMG / 精密把持 |
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| Outline of Final Research Achievements |
We previously showed that dexterous hand movements recovered in 1-3 months after the spinal cord injury limited to the lateral corticospinal tract in the dorsolateral funiculus (DLF) at the C4/C5 cervical segments in macaque monkeys. In this study, we longitudinally monitored the cortical activity during the reach and grasp task before and after the sub-hemisection, larger lesion than our previous model. The monkey started coarse power grasping after Day 32 post-injury. But the precision grip did not fully recover. The cortical electrical stimulation through each ECoG electrode (at 3 mA, 3 shocks at 20 Hz) was tested. Muscle twitch responses to stimulation of contralesional premotor and primary motor cortices gradually spread from the proximal to distal muscles including digits almost simultaneously as the monkey started grasping. These results suggested that global disinhibition in the cortical networks might be related to the recovery from spinal cord injury.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、脊髄損傷後の機能回復に関わる脳機能を調査した。損傷後には、脳の広範な領域で脱抑制が生じることが明らかになった。本研究の成果は、機能回復を導く運動学習機構の理解と、リハビリテーションの効果の評価・運動補助ロボットの開発・新たな治療法の創出につながるものと期待される。
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