Establishment of a mouse model of unilateral spatial neglect

• Project/Area Number: 18K17725
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Ibaraki Prefectural University of Health Science
• Principal Investigator: Ishii Daisuke 茨城県立医療大学, 保健医療学部, 准教授 (30803291)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 半側空間無視 / 脳卒中 / 動物モデル / リハビリテーション / モデル動物 / 脳梗塞 / 注意機能 / 高次機能障害

Outline of Final Research Achievements

Unilateral spatial neglect (USN) is a disorder of higher brain function that occurs after a brain injury, such as stroke, because patients with this condition often have other symptoms due to the presence of several brain lesions, it is difficult to evaluate the recovery mechanisms and effect of training on unilateral spatial neglect. In this study, we induced a focal infarction in the right medial agranular cortex (AGm) of mice using photothrombosis, and created a mouse model of USN.

Academic Significance and Societal Importance of the Research Achievements

半側空間無視（Unilateral Spatial Neglect: USN）は，大脳半球の損傷により生じる高次脳機能障害の1つで，損傷した大脳半球とは反対側へ注意を向けることや反応することが障害される．USNを呈した患者は，更衣や移動といった日常生活活動に支障を来し，在宅への復帰が困難となる．USN患者では脳の損傷部位が様々であり，呈する症状も一定でないことからリハビリテーションの効果を検証するのが難しく，USNに対するエビデンスの高い訓練は少ない．そこで，本研究ではUSNのモデルマウスを作製し、統制された条件下で効果的な治療法の開発へと展開するための基盤研究を行った。

Research Products

• [Journal Article] Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex: A mouse model of unilateral spatial neglect (2021)
  • Author(s): Daisuke Ishii, Hironobu Osaki, Arito Yozu, Kiyoshige Ishibashi, Kenta Kawamura, Satoshi Yamamoto, Mariko Miyata, Yutaka Kohno
  • Journal Title: Behavioural Brain Research Volume: 401 Pages: 113097-113097
  • DOI: 10.1016/j.bbr.2020.113097
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Visuospatial Attention on the Sensorimotor Gating System (2019)
  • Author(s): Ishii Daisuke、Takeda Kotaro、Yamamoto Satoshi、Noguchi Akira、Ishibashi Kiyoshige、Tanamachi Kenya、Yozu Arito、Kohno Yutaka
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 13 Pages: 1-5
  • DOI: 10.3389/fnbeh.2019.00001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Role of the right frontal orienting field in visuospatial attention (2020)
  • Author(s): Daisuke Ishii, Hironobu Osaki, Arito Yozu, Kiyoshige Ishibashi, Kenta Kawamura, Mariko Miyata, Yutaka Kohno
  • Organizer: 第97回 日本生理学会大会
• [Presentation] Laterality effects of the visual information processing on the sensorimotor gating system (2019)
  • Author(s): Daisuke Ishii, Kotaro Takeda, Satoshi Yamamoto, Akira Noguchi, Kiyoshige Ishibashi, Kenya Tanamachi, Arito Yozu, Yutaka Kohno
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research