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A Novel Strategy for Inspiratory Muscle Training Using the Illusion of Inspiratory Flow in Patients with COPD

Research Project

Project/Area Number 18K17741
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionHimeji Dokkyo University

Principal Investigator

Kanezaki Masashi  姫路獨協大学, 医療保健学部, 講師 (10707871)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords息切れ / L-メントール / 多次元的呼吸困難 / 慢性閉塞性肺疾患 / サルコペニア合併COPD / L-menthol嗅覚刺激 / メントール / 吸気抵抗負荷呼吸 / 呼吸困難 / COPD / 吸気流量知覚 / 吸気抵抗負荷 / 吸気筋
Outline of Final Research Achievements

This study investigated the effects of L-menthol on respiratory pattern and respiratory nerve drive (NRD), type and intensity of breathlessness, and emotional response during inspiratory resistive loading in patients with COPD. The inhalation resistance load was 20 and 30 cmH2O/L/s load. NRD was evaluated by EMGpara%max. L-menthol odor stimulation significantly decreased discomfort, respiratory effort and air hunger, and psychological respiratory effort during the loading compared with placebo and sham. In the emotional aspect of shortness of breath, L-menthol significantly decreased fear and anxiety compared to placebo. On the other hand, VE during inhalation, respiratory panting, and NRD were not significantly different among the three conditions.

Academic Significance and Societal Importance of the Research Achievements

慢性閉塞性肺疾患患者において、気管支拡張療法は主要な治療であるが、完全に息切れの病態を征圧するには困難であることが多い。L-mentholによる吸気流量知覚の増強は、呼吸神経ドライブ、換気量を抑制することなく吸気抵抗負荷時の息切れの緩和において有用である旨は、息切れを程する患者において重要な知見である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 2018 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results) Remarks (3 results)

  • [Journal Article] Effects of Sarcopenia on Ventilatory Behavior and the Multidimensional Nature of Dyspnea in Patients With Chronic Obstructive Pulmonary Disease2021

    • Author(s)
      Kanezaki Masashi、Terada Kunihiko、Tanabe Naoya、Shima Hiroshi、Hamakawa Yoko、Sato Susumu
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: 22 Issue: 4 Pages: 827-833

    • DOI

      10.1016/j.jamda.2021.01.081

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Olfactory Stimulation by L-Menthol on Laboratory-Induced Dyspnea in COPD2020

    • Author(s)
      Kanezaki Masashi、Terada Kunihiko、Ebihara Satoru
    • Journal Title

      Chest

      Volume: in press Issue: 6 Pages: 1455-1465

    • DOI

      10.1016/j.chest.2019.12.028

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alleviation of Dyspnea Sensation by Phototherapy in Healthy Adults2019

    • Author(s)
      Izukura Hideaki、Kanezaki Masashi、Ebihara Satoru
    • Journal Title

      Respiratory Care

      Volume: 64 Issue: 9 Pages: 1082-1087

    • DOI

      10.4187/respcare.06496

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of facial skin cooling induced by a handheld fan on the cough reflex threshold and urge to cough induced by citric acid2019

    • Author(s)
      Kanezaki Masashi、Ebihara Satoru
    • Journal Title

      ERJ Open Research

      Volume: 5 Issue: 4 Pages: 00089-2019

    • DOI

      10.1183/23120541.00089-2019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 咳嗽に対する最新非薬物療法2019

    • Author(s)
      金崎雅史
    • Journal Title

      アレルギーの臨床

      Volume: 39 Pages: 332-334

    • Related Report
      2018 Research-status Report
  • [Journal Article] Alleviation of dyspnea sensation by phototherapy in healthy adults2019

    • Author(s)
      Izukura H, Kanezaki M and Ebihara S
    • Journal Title

      Respiratory Care

      Volume: In Press

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Distractive Auditory Stimuli on the Cough Reflex Threshold and Urge-to-Cough Induced by Citric Acid in Healty Never-smokers2018

    • Author(s)
      金﨑 雅史, 古川 菜々美, 太田垣 沙和, 沖中 郁美
    • Journal Title

      Physical Therapy Japan

      Volume: 45 Issue: 5 Pages: 304-308

    • DOI

      10.15063/rigaku.11426

    • NAID

      130007499794

    • ISSN
      0289-3770, 2189-602X
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 慢性閉塞性肺疾患患者及び高齢者におけるL-メントール嗅覚刺激が吸気抵抗負荷誘発性呼吸困難に及ぼす影響の検討2020

    • Author(s)
      金崎 雅史, 寺田 邦彦
    • Organizer
      第28回バイオフィジオロジー研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Multidimensional Dyspnea Profile日本語版の開発2019

    • Author(s)
      金崎 雅史 , 玉木 彰 , 寺田 邦彦 , 海老原 覚
    • Organizer
      日本呼吸ケア・リハビリテーション学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 慢性閉塞性肺疾患患者におけるL-mentholによる吸気流量錯覚は息切れの緩和に有用である MeDCOPD試験2019

    • Author(s)
      金崎 雅史, 寺田 邦彦, 海老原 覚
    • Organizer
      日本呼吸ケア・リハビリテーション学会誌
    • Related Report
      2019 Research-status Report
  • [Presentation] COPDにおけるメントールが呼吸パターン,呼吸神経ドライブおよび 呼吸困難の感覚的・情動的側面に及ぼす影響の検討2019

    • Author(s)
      金崎 雅史, 寺田 邦彦
    • Organizer
      第93回閉塞性肺疾患研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effect of Olfactory Stimulation by L-menthol on Sensory and Affective Dimension of Dyspnea During Inspiratory Resistive Loaded Breathing in COPD2019

    • Author(s)
      Masashi Kanezaki, Kumihiko Terada, Satoru Ebihara
    • Organizer
      European Respiratory Society
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Handheld fanによる顔面の送風は咳反射・咳衝動を低下させる2018

    • Author(s)
      金崎雅史, 海老原覚
    • Organizer
      第27回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Handheld fan による顔面の送風がクエン酸誘発性咳反射閾値および咳衝動に及ぼす影響 の検討2018

    • Author(s)
      金崎雅史, 海老原覚
    • Organizer
      第20回日本咳嗽学会
    • Related Report
      2018 Research-status Report
  • [Remarks] 第29回Pneumo Forum受賞演題のお知らせ

    • URL

      https://www.jrs.or.jp/modules/information/index.php?content_id=1599&fbclid=IwAR3CKQuoKaWrhoK3JwHptMp0W_FuLOijCJYACQRhyyYPfPz1A2gy0dihhQQ

    • Related Report
      2020 Annual Research Report
  • [Remarks]

    • URL

      https://www.donaldmahler.com/inhaled-menthol-reduces-breathlessness/?fbclid=IwAR3UL2lZajnSqMNLYBW-Mg4G07Ru3njAxmx83nTJlQh807BCWIy3i-wA6Vk

    • Related Report
      2020 Annual Research Report
  • [Remarks]

    • URL

      https://journal.chestnet.org/article/S0012-3692(20)30466-9/pdf?fbclid=IwAR1BgiSzhvYuGGY-NsT9pg_MSwygFKBhMGdM34VSNHvRKMgnX2JC8t9vltw

    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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