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A Study on the Neurophysiological Effects of Transcutaneous Spinal Cord Stimulation

Research Project

Project/Area Number 18K17760
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionTokyo International University

Principal Investigator

Masugi Yohei  東京国際大学, 教育研究推進機構, 講師 (60778942)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脊髄反射 / 経皮的脊髄刺激 / 健常者 / H反射 / 脊髄 / 脊髄刺激 / 反射 / リハビリテーション / 歩行 / ニューロモデュレーション / 脊髄損傷
Outline of Final Research Achievements

The purpose of this study is to establish a new non-invasive rehabilitation method to promote the recovery of motor functions after spinal cord injury. In order to achieve this goal, the purpose of this study was to further develop the transcutaneous spinal cord stimulation (tSCS) method and to elucidate the neurophysiological effects and mechanisms of repetitive tSCS.
This study revealed the characteristics of neural circuits activated by tSCS and the inhibitory effects of repetitive tSCS on spinal reflex circuits.

Academic Significance and Societal Importance of the Research Achievements

脊髄刺激法の確立およびその生理学的効果の解明は、国外の研究を中心に多くの研究者が取り組み始めた課題である。本研究では、侵襲を伴わない経皮的脊髄刺激法に着目をしてその効果を明らかにした。本研究の結果から、連続的な経皮的脊髄刺激によって脊髄反射回路の興奮性が低下することが明らかになった。このことは、中枢神経疾患後にみられる痙縮の症状を緩和できる可能性を示唆した。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019 2018

All Journal Article (12 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 12 results,  Open Access: 5 results)

  • [Journal Article] Phase dependent modulation of cortical activity during action observation and motor imagery of walking: An EEG study2021

    • Author(s)
      Kaneko Naotsugu、Yokoyama Hikaru、Masugi Yohei、Watanabe Katsumi、Nakazawa Kimitaka
    • Journal Title

      NeuroImage

      Volume: 225 Pages: 117486-117486

    • DOI

      10.1016/j.neuroimage.2020.117486

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inter-muscle differences in modulation of motor evoked potentials and posterior root-muscle reflexes evoked from lower-limb muscles during agonist and antagonist muscle contractions2020

    • Author(s)
      Saito Akira、Nakagawa Kento、Masugi Yohei、Nakazawa Kimitaka
    • Journal Title

      Experimental Brain Research

      Volume: 239 Issue: 2 Pages: 463-474

    • DOI

      10.1007/s00221-020-05973-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interlimb neural interactions in corticospinal and spinal reflex circuits during preparation and execution of isometric elbow flexion2020

    • Author(s)
      Atsushi Sasaki, Naotsugu Kaneko, Yohei Masugi, Matija Milosevic and Kimitaka Nakazawa
    • Journal Title

      Journal of Neurophysiology

      Volume: 124(3) Issue: 3 Pages: 652-667

    • DOI

      10.1152/jn.00705.2019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Changes in corticospinal excitability during bilateral and unilateral lower-limb force control tasks2020

    • Author(s)
      Akiko Yamaguchi, Atsushi Sasaki, Yohei Masugi, Matija Milosevic and Kimitaka Nakazawa
    • Journal Title

      Experimental Brain Research

      Volume: 238(9) Issue: 9 Pages: 1977-1987

    • DOI

      10.1007/s00221-020-05857-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Gait‐phase‐dependent and gait‐phase‐independent cortical activity across multiple regions involved in voluntary gait modifications in humans2020

    • Author(s)
      Hikaru Yokoyama, Naotsugu Kaneko, Yohei Masugi, Tetsuya Ogawa, Katsumi Watanabe, Kimitaka Nakazawa
    • Journal Title

      European Journal of Neuroscience

      Volume: - Issue: 12 Pages: 652-667

    • DOI

      10.1111/ejn.14867

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Muscle-Specific Modulation of Spinal Reflexes in Lower-Limb Muscles during Action Observation with and without Motor Imagery of Walking.2019

    • Author(s)
      Kaneko N, Masugi Y, Usuda N, Yokoyama H, Nakazawa K.
    • Journal Title

      Brain Sciences

      Volume: 9(12) Issue: 12 Pages: 333-333

    • DOI

      10.3390/brainsci9120333

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Remote muscle contraction enhances spinal reflexes in multiple lower-limb muscles elicited by transcutaneous spinal cord stimulation2019

    • Author(s)
      Masugi Yohei、Sasaki Atsushi、Kaneko Naotsugu、Nakazawa Kimitaka
    • Journal Title

      Experimental Brain Research

      Volume: 印刷中 Issue: 7 Pages: 1793-1803

    • DOI

      10.1007/s00221-019-05536-9

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Repeatability of spinal reflexes of lower limb muscles evoked by transcutaneous spinal cord stimulation2019

    • Author(s)
      Saito A, Masugi Y, Nakagawa K, Obata H, Nakazawa K.
    • Journal Title

      PLoS ONE

      Volume: 14 Issue: 4 Pages: e0214818-e0214818

    • DOI

      10.1371/journal.pone.0214818

    • NAID

      120006800703

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] On the reflex mechanisms of cervical transcutaneous spinal cord stimulation in human subjects2019

    • Author(s)
      Milosevic Matija、Masugi Yohei、Sasaki Atsushi、Sayenko Dimitry G.、Nakazawa Kimitaka
    • Journal Title

      Journal of Neurophysiology

      Volume: 121 Issue: 5 Pages: 1672-1679

    • DOI

      10.1152/jn.00802.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Short-term inhibition of spinal reflexes in multiple lower limb muscles after neuromuscular electrical stimulation of ankle plantar flexors2018

    • Author(s)
      Milosevic Matija、Masugi Yohei、Obata Hiroki、Sasaki Atsushi、Popovic Milos R.、Nakazawa Kimitaka
    • Journal Title

      Experimental Brain Research

      Volume: 237 Issue: 2 Pages: 467-476

    • DOI

      10.1007/s00221-018-5437-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Modulation of Hoffmann reflex excitability during action observation of walking with and without motor imagery2018

    • Author(s)
      Kaneko Naotsugu、Masugi Yohei、Usuda Noboru、Yokoyama Hikaru、Nakazawa Kimitaka
    • Journal Title

      Neuroscience Letters

      Volume: 684 Pages: 218-222

    • DOI

      10.1016/j.neulet.2018.07.041

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of motor imagery on spinal reflex excitability of multiple muscles2018

    • Author(s)
      Nakagawa Kento、Masugi Yohei、Saito Akira、Obata Hiroki、Nakazawa Kimitaka
    • Journal Title

      Neuroscience Letters

      Volume: 668 Pages: 55-59

    • DOI

      10.1016/j.neulet.2018.01.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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