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Studies on the effects of ketogenic diet feeding on endurance performance and its mechanism

Research Project

Project/Area Number 18K17767
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

Kakehashi Chiaki  聖マリアンナ医科大学, 医学部, 研究技術員 (80535683)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsケトン餌 / 筋持久力 / 筋組成 / 有酸素運動 / 遅筋化 / ミオシン / ケトン / 超高脂肪食 / 骨格筋 / Sema3A / 遅筋 / 機能性食品 / ケトン食 / ケトン体誘導食
Outline of Final Research Achievements

Our study confirmed that feeding of a ketogenic diet changed fast-type muscle to slow-type muscle in extensor digitorum longus in rats. In this muscle, mitochondrial and metabolic enzymes were increased. These changes increased the aerobic exercise ability of the rats. Sema3A might be involved in the muscle-type change. After substituting the rats with mice for a second experiment, we examined ketogenic diet effects on muscle weight, strength, and endurance in mice. No statistical significance was found.

Academic Significance and Societal Importance of the Research Achievements

運動効果を高める手段の開発は、運動時間がとれない現代人にとって重要である。運動効果を向上できれば、健康増進に貢献できるからである。我々は、超高脂肪食ともいえるケトン食の摂取が、ラット骨格筋の代謝特性を遅筋型へシフトさせること発見した。これは、食事の内容を工夫するだけで運動をしたような効果があることを示唆しており、また、糖尿病などの運動療法を食事だけで模倣できる可能性を示唆している。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 2018 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Journal Article] Ketogenic diet feeding improves aerobic metabolism property in extensor digitorum longus muscle of sedentary male rats2020

    • Author(s)
      Ogura Yuji、Kakehashi Chiaki、Yoshihara Toshinori、Kurosaka Mitsutoshi、Kakigi Ryo、Higashida Kazuhiko、Fujiwara Sei-Etsu、Akema Tatsuo、Funabashi Toshiya
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 10 Pages: 1-16

    • DOI

      10.1371/journal.pone.0241382

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Four-week Ketogenic Diet Improves Aerobic Metabolic Capacity in Extensor Digitrum Longus Muscle of Sedentary Male Rats2020

    • Author(s)
      Yuji Ogura, Toshinori Yoshihara, Mitsutoshi Kurosaka, Ryo Kakigi, Sei-etsu Fujiwara, Chiaki Kakehashi, Kazuhiko Higashida, and Toshiya Funabashi
    • Organizer
      Experimental Biology 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ketogenic diet induces slow-type shift of skeletal muscle in male rat2019

    • Author(s)
      Yuji Ogura, Mitsutoshi Kurosaka, Chiaki Kakehashi, Ryo Kakigi, Tatsuo Akema, Toshiya Funabashi
    • Organizer
      FAOPS2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ketogenic diet induces slow-type shift of skeletal muscle in male rat2018

    • Author(s)
      Ogura Y, Kurosaka M, Kakehashi C, Kakigi R, Akema T, Funabashi T
    • Organizer
      FAOPS2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] ケトン餌による学習機能と筋組成変化

    • URL

      https://www.marianna-u.ac.jp/houjin/academic/20210224_01/index.html

    • Related Report
      2020 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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