| Project/Area Number |
18K17776
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Osaka University of Human Sciences |
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Principal Investigator |
Kanazawa Yuji 大阪人間科学大学, 保健医療学部, 講師 (60620656)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 老化 / 骨格筋 / 基底板 / 線維芽細胞 / コラーゲン / 運動 / Collagen IV / TCF4 / リハビリテーション |
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| Outline of Final Research Achievements |
In the present study, it was found that (1) intramuscular fibroblasts play an important role in the reconstruction of the basement membrane, (2) aging decreases basement membrane related factors not only during muscle recovery but also from the steady state, and (3) endurance exercise activates basement membrane related factors in aging. These results suggest that exercise intervention may stimulate the production of collagen IV by fibroblasts and improve the basement membrane construction ability in aged skeletal muscle.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、老化した骨格筋においても運動介入によって線維芽細胞によるコラーゲンⅣの産生を促し、基底板構築能を改善する可能性が示された。運動介入は、筋の脆弱化を引き起こす病態に対する予防的措置に応用できる可能性があると考えられる。したがって、本研究成果は、老化に伴う身体機能の低下に対する治療開発に寄与するものと考える。
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