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Prediction of rehabilitation effect in Parkinson's Disease using neuropsychological assessment including Procedural Memory and Brain Imaging

Research Project

Project/Area Number 18K17778
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionHyogo Medical University

Principal Investigator

Marumoto Kohei  兵庫医科大学, 医学部, 非常勤講師 (80594738)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords手続き記憶 / 運動学習 / パーキンソン病 / リハビリテーション / SRTT / 順序ボタン押し課題 / ニューロモデュレーション / 拡散テンソル画像 / 強化集学的ケア / 集学的リハビリテーション
Outline of Final Research Achievements

One of the goals of rehabilitation is to promote learning of optimal movements for the patient, and most of the activities of daily living (ADL) are automatic and retained by unconscious learning and procedural memory. Most of the activities of daily living (ADL) are automated and maintained by implicit learning and procedural memory. However, few studies have examined the relationship between procedural memory and rehabilitation effects. Therefore, we studied patients with Parkinson's disease (PD), a degenerative disease that mainly affects the midbrain-basal ganglia-cortex circuitry and results in impairment of procedural memory. We assessed the ability of procedural memory with the serial reaction time task (SRTT) and investigated its relation to the rehabilitation effect. We found an association between procedural memory measures and improvement in ADL. It is possible that procedural memory impairment is a barrier to ADL acquisition in PD.

Academic Significance and Societal Importance of the Research Achievements

リハビリの効果に差が出る原因の一つとして手続き記憶能力の差がある。リハビリは患者に最適な動作を学習させることであり、ADLのほとんどが潜在的学習や手続き記憶の結果として自動化、保持される。今回の研究ではそれを裏付ける結果を示した。これまで臨床現場で簡便に潜在的学習や手続き記憶を評価する方法がなかった。我々はその評価法の開発ならびに臨床応用を行った。この研究の成果によって様々な疾患においてリハビリの実施前にこの評価を行い、個人特性を評価してリハビリプログラムを作成することができるようになった。日本のみならず世界中でたくさんの患者がリハビリを受けており、社会的にも非常に有意義な研究であった。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2021 2020 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Inpatient Enhanced Multidisciplinary Care Effects on the Quality of Life for Parkinson Disease: A Quasi-Randomized Controlled Trial2019

    • Author(s)
      Kohei Marumoto, Kazumasa Yokoyama, Tomomi Inoue, Hiroshi Yamamoto, Yuki Kawami, Ayumi Nakatani, Yoshihiro Fukazawa, Yayoi Hosoe, Aki Yamasaki, Kazuhisa Domen
    • Journal Title

      Journal of Geriatric Psychiatry and Neurology

      Volume: 32 Issue: 4 Pages: 186-194

    • DOI

      10.1177/0891988719841721

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] パーキンソン病患者の順序ボタン押し課題の特徴とリハビリ効果2021

    • Author(s)
      丸本浩平, 平田亜希, 山本孝代, 永井厚志, 中谷綾佑美, 松ヶ下壮, 井上ともみ, 高橋竜一, 水田英二
    • Organizer
      第14回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳深部刺激療法(DBS)を実施されたパーキンソン病患者のリハビリテーション治療効果2020

    • Author(s)
      丸本 浩平, 水田 英二, 田中 貴志, 柳内 章宏, 金澤 慎一郎, 加藤 順一, 道免 和久
    • Organizer
      第57回日本リハビリテーション医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Inpatient multidisciplinary rehabilitation effects on the quality of life for Parkinson's disease: A quasi-randomized controlled trial2019

    • Author(s)
      Kohei Marumoto, Kazumasa Yokoyama, Eiji Mizuta, Aki Yamasaki, Kazuhisa Domen
    • Organizer
      5th World Parkinson Congress
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inpatient enhanced multidisciplinary care effects on the quality of life for Parkinson's disease2019

    • Author(s)
      Kohei Marumoto, Kazumasa Yokoyama, Eiji Mizuta, Aki Yamasaki, Tomomi Inoue, Hiroshi Yamamoto, Yuki Kawami, Ayumi Nakatani, Yoshihiro Fukazawa, Yayoi Hosoe, Kazuhisa Domen
    • Organizer
      13th International Society of Physical and Rehabilitation Medicine World Congress
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 看護師主導の強化集学的ケアがパーキンソン病のQOLに与える効果 :準ランダム化比較試験2019

    • Author(s)
      丸本 浩平、横山和正、山本洋史、坪田憲明、林田正子、山本孝代、川見優貴、中谷綾佑美、深澤喜啓、井上ともみ、細江弥生、水田英二
    • Organizer
      第13回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2019 Research-status Report 2018 Research-status Report
  • [Book] パーキンソン病の看護と日常生活支援: 在宅看護・地域医療にかかわる全スタッフ必携!2019

    • Author(s)
      紙屋克子(監修) 丸本浩平(医療監修) 山下哲平(編) パーキンソン病看護研究会(著)
    • Total Pages
      192
    • Publisher
      メディカ出版
    • ISBN
      9784840465953
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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