身体活動が認知機能を改善・発達させる神経ネットワークの同定

• Project/Area Number: 18K17832
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Kobe University (2020-2021); Hokkaido University (2019); Tamagawa University (2018)
• Principal Investigator: 石原 暢 神戸大学, 人間発達環境学研究科, 助教 (10801631)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Granted (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 身体活動 / 体力 / 認知機能 / 磁気共鳴画像法 / 反応抑制 / ワーキングメモリー / 生理学 / 運動生理学 / 認知科学

Outline of Annual Research Achievements

近年の研究により、身体活動は加齢に伴う認知機能の衰退予防だけでなく、子どもから青年期においても認知機能を改善、発達させるための１つの手段となり得ることが報告されている。しかし、身体活動が脳構造や機能に与える効果に関する知見は乏しい状況にある。磁気共鳴画像 (MRI) を用いた研究により、身体活動は前頭前野背外側部や海馬の体積を増大させることが報告されているものの、脳の機能レベルで身体活動の効果を理解するためには、脳領域間の解剖学的ならびに神経活動レベルでの繋がりの変化を調べる必要がある。
そこで本研究では、近年公開されたMRIで脳の構造・機能をより正確かつ詳細に計測・解析できる Human Connectome Project (HCP) 準拠のプロトコールで撮像したMRIデータ、ならびに解析パイプラインを用いて、20歳から60歳の健常者を対象に身体活動量と認知機能の成績に関わる脳の構造・機能的領域間結合の関連を詳細に検討し、身体活動が認知機能を改善、発達させる背景にある神経ネットワークの変化を明らかにすることを目的としている。
令和3年度にはマルチモーダルMRIデータ（T1, T2, rs-fMRI, dMRI）の解析手法を確立し、データ分析および論文執筆を順調に進めた。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

新型コロナウイルス感染症の対応のため、データの収集に遅延が遅れたため、その分データ分析と論文執筆に遅れが出ているため。

Strategy for Future Research Activity

2022年度は引き続き得られたデータの分析、学会での成果報告、論文化を進める予定である。

Research Products

• [Int'l Joint Research] University of Basel(スイス)
• [Int'l Joint Research] Edith Cowan University(オーストラリア)
• [Int'l Joint Research] Northeastern University/University of North Carolina(米国)
• [Int'l Joint Research] Northeastern University/University of North Carolina(米国)
• [Int'l Joint Research] University of Basel(スイス)
• [Int'l Joint Research] Northeastern University/University of North Carolina(米国)
• [Int'l Joint Research] University of Basel(スイス)
• [Int'l Joint Research] Northeastern University/University of North Carolina(米国)
• [Int'l Joint Research] University of Basel(スイス)
• [Journal Article] Content validity and reliability of an enjoyable multicomponent agility test for boys: The N-challenge test (2022)
  • Author(s): Morita Noriteru、Ishihara Toru、Yamamoto Rihito、Shide Noriyuki、Okuda Tomoyasu
  • Journal Title: Journal of Sports Sciences Volume: 40 Pages: 976-983
  • DOI: 10.1080/02640414.2022.2043698
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Investigating the role of age and maturation on the association between tennis experience and cognitive function in junior beginner to intermediate-level tennis players (2022)
  • Author(s): Turner Mitchell、Ishihara Toru、Beranek Philipp、Turner Kate、Fransen Job、Born Philipp、Cruickshank Travis
  • Journal Title: International Journal of Sports Science & Coaching Volume: 17 Pages: 174795412110558-174795412110558
  • DOI: 10.1177/17479541211055841
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Longitudinal Associations Between Physical Activity, Body Mass Index and Inhibitory Control in Children with ADHD: Mediation by Brain Structure (2022)
  • Author(s): Ludyga Sebastian、Ishihara Toru
  • Journal Title: SSRN Electronic Journal Volume: NA
  • DOI: 10.2139/ssrn.4008157
  • Open Access / Int'l Joint Research
• [Journal Article] The effects of acute aerobic exercise on executive function: A systematic review and meta-analysis of individual participant data (2021)
  • Author(s): Ishihara Toru、Drollette Eric S.、Ludyga Sebastian、Hillman Charles H.、Kamijo Keita
  • Journal Title: Neurosci Biobehav Rev Volume: 128 Pages: 258-269
  • DOI: 10.1016/j.neubiorev.2021.06.026
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Childhood exercise predicts response inhibition in later life via changes in brain connectivity and structure (2021)
  • Author(s): Ishihara Toru、Miyazaki Atsushi、Tanaka Hiroki、Fujii Takayuki、Takahashi Muneyoshi、Nishina Kuniyuki、Kanari Kei、Takagishi Haruto、Matsuda Tetsuya
  • Journal Title: NeuroImage Volume: 237 Pages: 118196-118196
  • DOI: 10.1016/j.neuroimage.2021.118196
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children's Health (2021)
  • Author(s): Miura Ryu、Ikeda-Araki Atsuko、Ishihara Toru、Miyake Kunio、Miyashita Chihiro、Nakajima Tamie、Kobayashi Sumitaka、Ishizuka Mayumi、Kubota Takeo、Kishi Reiko
  • Journal Title: Science of The Total Environment Volume: 783 Pages: 147035-147035
  • DOI: 10.1016/j.scitotenv.2021.147035
  • Peer Reviewed
• [Journal Article] Differential effects of changes in cardiorespiratory fitness on worst- and best- school subjects. (2021)
  • Author(s): Ishihara T, Morita N, Nakajima T, Yamatsu K, Okita K, Sagawa M, Kamijo K.
  • Journal Title: NPJ Sci Learn Volume: 1 Pages: 8-8
  • DOI: 10.1038/s41539-021-00086-8
  • Peer Reviewed / Open Access
• [Journal Article] Extracurricular Activity on Music and Visual Art Associates with Children’ Academic Achievement by Transferring Each Subject Score (2021)
  • Author(s): Ishiguro Chiaki、Ishihara Toru、Morita Noriteru
  • Journal Title: Research Square Volume: NA
  • DOI: 10.21203/rs.3.rs-620557/v1
  • Open Access
• [Journal Article] Exposure to Radiofrequency Electromagnetic Field in the High-Frequency Band and Cognitive Function in Children and Adolescents: A Literature Review. (2020)
  • Author(s): Ishihara T, Yamazaki K, Araki A, Teraoka Y, Tamura N, Hikage T, Omiya M, Mizuta M, Kishi R.
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 17 Pages: 9179-9179
  • DOI: 10.3390/ijerph17249179
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal relationship of favorable weight change to academic performance in children. (2020)
  • Author(s): Ishihara T, Nakajima T, Yamatsu K, Okita K, Sagawa M, Morita N.
  • Journal Title: npj Science of Learning Volume: 5 Pages: 4-4
  • DOI: 10.1038/s41539-020-0063-z
  • Peer Reviewed / Open Access
• [Journal Article] Identification of the brain networks that contribute to the interaction between physical function and working memory: An fMRI investigation with over 1,000 healthy adults. (2020)
  • Author(s): Ishihara T, Miyazaki A, Tanaka H, Matsuda T.
  • Journal Title: NeuroImage Volume: 221 Pages: 117152-117152
  • DOI: 10.1016/j.neuroimage.2020.117152
  • NAID: 120007002561
  • Peer Reviewed / Open Access
• [Journal Article] Relationship of participation in specific sports to academic performance in adolescents: A 2-year longitudinal study. (2020)
  • Author(s): Ishihara T, Nakajima T, Yamatsu K, Okita K, Sagawa M, Morita N.
  • Journal Title: Scandinavian Journal of Medicine & Science in Sports Volume: 30 Pages: 1471-1482
  • DOI: 10.1111/sms.13703
  • Peer Reviewed
• [Journal Article] Baseline Cognitive Performance Moderates the Effects of Physical Activity on Executive Functions in Children. (2020)
  • Author(s): Ishihara T, Drollette ES, Ludyga S, Hillman CH, Kamijo K.
  • Journal Title: Journal of Clinical Medicine Volume: 9 Pages: 2071-2071
  • DOI: 10.3390/jcm9072071
  • NAID: 120006882472
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Competitive achievement may be predicted by executive functions in junior tennis players: An 18-month follow-up study (2019)
  • Author(s): Ishihara, T., Kuroda, Y., & Mizuno, M.
  • Journal Title: Journal of Sports Sciences Volume: 37(7) Pages: 755-761
  • DOI: 10.1080/02640414.2018.1524738
  • Peer Reviewed
• [Journal Article] Relationships between tennis experience, executive function, and self-regulation of dietary behavior in children (2018)
  • Author(s): Ishihara, T., Kuroda, Y., & Mizuno, M.
  • Journal Title: International Journal of Sport and Exercise Psychology Volume: Advance online publication
  • DOI: 10.1080/1612197x.2018.1511625
  • Peer Reviewed
• [Journal Article] Relationship between attention shifting and tennis performance during singles matches (2018)
  • Author(s): Ishihara, T., Kobayashi, T., Kuroda, Y., & Mizuno, M.
  • Journal Title: The Journal of Sports Medicine and Physical Fitness Volume: 58 Pages: 1883-1888
  • DOI: 10.23736/s0022-4707.18.08161-6
  • Peer Reviewed
• [Journal Article] Effects of tennis play on executive function in 6-11-year-old children: A 12-month longitudinal study (2018)
  • Author(s): Ishihara, T., & Mizuno, M.
  • Journal Title: European Journal of Sport Science Volume: 18(5) Pages: 741-752
  • DOI: 10.1080/17461391.2018.1444792
  • Peer Reviewed
• [Journal Article] Modeling relationships of achievement motivation and physical fitness to academic performance in Japanese schoolchildren: Moderation by gender (2018)
  • Author(s): Ishihara, T., Morita, N., Nakajima, T., Okita, K., Sagawa, M., & Yamatsu, K.
  • Journal Title: Physiology & Behavior Volume: 194 Pages: 66-72
  • DOI: 10.1016/j.physbeh.2018.04.031
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 大脳皮質構造と年齢、体組成、運動習慣の関係 (2022)
  • Author(s): 石原暢, 宮崎淳, 高岸治人, 松田哲也
  • Organizer: 第24回日本ヒト脳機能マッピング学会
• [Presentation] 体力・肥満と認知機能 (2021)
  • Author(s): 石原暢
  • Organizer: 生理学研究所研究会「脳・環境・臓器間ネットワークと社会性」
  • Invited
• [Presentation] 学力とスポーツ競技力を同時に高めることは可能なのか？ (2021)
  • Author(s): 石原暢
  • Organizer: 第76回日本体力医学会大会, シンポジウム11 「運動・スポーツと脳 ―文武両道は成り立つのか？―」
  • Invited
• [Presentation] 運動・体力と認知機能の関係：脳マルチモーダルMRI研究 (2021)
  • Author(s): 石原暢
  • Organizer: 第４回 スポーツニューロサイエンス研究会, シンポジウム 「新しいライフスタイルに向けた運動と脳神経科学」
  • Invited
• [Presentation] 運動・体力と脳内ネットワーク (2021)
  • Author(s): 石原暢
  • Organizer: 第29回日本運動生理学会大会, シンポジウム3 「運動がもたらす認知機能の変化：最新の知見と展望」
  • Invited
• [Presentation] 運動が子どもの学力と認知機能に与える影響 (2021)
  • Author(s): 石原暢
  • Organizer: 第2回日本体力医学会北九州地方会学術集会, シンポジウム 「脳の健康への身体活動科学の貢献」
  • Invited
• [Presentation] Association of cardiovascular risk markers and physical fitness with task-related neural activity during social cognition (2021)
  • Author(s): Ishihara, T., Miyazaki, A., Tanaka, H., & Matsuda, T.
  • Organizer: 44th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Playing in online eSport tournament enhances psychological vigor with neurohumoral responses to winning or losing (2021)
  • Author(s): Matsui, T., Monma, T., Sagayama, H., Hyodo, K., Shima, T., Ishihara, T., Fujii, N., & Takagi, H.
  • Organizer: 44th Annual Meeting of the Japan Neuroscience Society
• [Presentation] 思春期以前の親からの拒絶体験と成人期の海馬体積および社会機能 (2021)
  • Author(s): 川元茉莉乃, 高岸治人, 石原暢, 髙木俊輔, 金井良太, 杉原玄一, 髙橋英彦, 松田哲也
  • Organizer: 第5回ヒト脳イメージング研究会
• [Presentation] 多要素で構成されるアジリティテスト「Nチャレンジ」の信頼性および妥当性 (2021)
  • Author(s): 森田憲輝, 石原暢, 山本理人, 志手典之, 奥田知靖
  • Organizer: 日本体育・スポーツ・健康学会第71回大会
• [Presentation] eスポーツのオフラインプレーが高める気分とオキシトシン分泌 (2021)
  • Author(s): 松井崇, 門間貴史, 下山寛之, 兵頭和樹, 島孟留, 石原暢, 藤井直人, 高木英樹
  • Organizer: 日本体育・スポーツ・健康学会第71回大会
• [Presentation] Development of inequity aversion: A cross sectional study from adolescence to adulthood (2021)
  • Author(s): Shou, Q., Miyazaki, A., Yamada, J., Tanaka, H., Ishihara, T., Fujii, T., Takahashi, M., Okada, H., Matsuda, T., & Takagishi, H.
  • Organizer: The 32nd International Congress of Psychology
  • Int'l Joint Research
• [Presentation] Developmental changes in trust and reciprocity: Cross sectional study from adolescence to adulthood (2021)
  • Author(s): Yamada, J., Miyazaki, A., Shou, Q., Tanaka, H., Ishihara, T., Fujii, T., Takahashi, M., Okada, H., Matsuda, T., & Takagishi, H.
  • Organizer: The 32nd International Congress of Psychology
  • Int'l Joint Research
• [Presentation] 子どもの運動・体力と高次認知機能の関係 (2020)
  • Author(s): 石原暢
  • Organizer: 第39回日本臨床運動療法学会学術集会
  • Invited
• [Presentation] Association between children’s physical fitness and performance on academic subjects (2020)
  • Author(s): Ishihara, T., Kamijo, K., Nakajima, T., Yamatsu, K., Okita, K., Sagawa, M., & Morita, N.
  • Organizer: The 2020 Yokohama Sport Conference
  • Int'l Joint Research
• [Presentation] Baseline cognitive performance moderates the benefits of regular exercise on cognition in children (2020)
  • Author(s): Kamijo, K., Ishihara, T., Drollette, E.S., Ludyga, S., & Hillman, C.H.
  • Organizer: American College of Sports Medicine 67th Annual Meeting
  • Int'l Joint Research
• [Presentation] 健常成人における過体重・肥満と実行機能・ 社会認知機能および課題関連脳活動の関係 (2020)
  • Author(s): 石原暢, 宮崎淳, 田中大貴, 松田哲也
  • Organizer: 第22回日本ヒト脳機能マッピング学会
• [Presentation] The negative association of body mass index to working memory and theory of mind in young and middle-aged adults: A task-fMRI study (2020)
  • Author(s): Ishihara, T., Miyazaki, A., Tanaka, H., & Matsuda, T.
  • Organizer: 43rd Annual Meeting of the Japan Neuroscience Society
• [Presentation] 子どもの体力と学力の関係：年齢層と年次変化に着目して (2020)
  • Author(s): 石原暢, 森田憲輝, 紙上敬太
  • Organizer: 日本発育発達学会第18回大会
• [Presentation] 日本の子供の運動習慣・体力と学力および認知機能の関係 ―これまでの研究成果と今後の課題― (2019)
  • Author(s): 石原暢
  • Organizer: 第74回 日本体力医学会大会 シンポジウム
• [Presentation] Relationship of multiple aspects of physical fitness to cognitive control: An fMRI investigation with over 1,000 young and middle-aged adults (2019)
  • Author(s): Ishihara, T., Miyazaki, A., Tanaka, H., Fujii, T., Takahashi, M., & Matsuda, T.
  • Organizer: 24th Annual Congress of the European College of Sport Science
  • Int'l Joint Research
• [Presentation] Modeling the relationship of physical fitness to working memory via fMRI activation and performance (2019)
  • Author(s): Ishihara, T., Miyazaki, A., Tanaka, H., Fujii, T., Takahashi, M., & Matsuda, T.
  • Organizer: 25th Annual Meeting of the Organization for Human Brain Mapping
  • Int'l Joint Research
• [Presentation] 体力・運動機能および体格と社会認知機能の関係 (2019)
  • Author(s): 石原暢, 宮崎淳, 田中大貴, 松田哲也
  • Organizer: 北海道体育学会 第59回大会
• [Presentation] 幼少期の運動経験と成人後の認知機能，脳神経コネクトーム，および皮質構造の関係： 脳マルチモーダルMRIデータを用いた検討 (2019)
  • Author(s): 石原暢, 宮崎淳, 田中大貴, 藤井貴之, 金成慧, 仁科国之, 高橋宗良, 高岸治人, 松田哲也
  • Organizer: 第74回 日本体力医学会大会
• [Presentation] The relationship between obesity and age-related structural brain changes: A multimodal MRI study using the Human Connectome Project-style paradigm (2019)
  • Author(s): Ishihara, T., Miyazaki, A., Tanaka, H., Fujii, T., Takahashi, M., Matsumoto, Y., Kiyonari, T., Takagishi, H., & Matsuda, T.
  • Organizer: 42nd Annual Meeting of the Japan Neuroscience Society
• [Presentation] Relationship of multiple aspects of physical fitness to cognitive control: An fMRI investigation with over 1,000 young and middle-aged adults. (2019)
  • Author(s): Ishihara, T., Miyazaki, A., Tanaka, H., Fujii, T., Takahashi, M., & Matsuda, T.
  • Organizer: European Collage of Sport Science
  • Int'l Joint Research
• [Presentation] Modeling the relationship of physical fitness to working memory via fMRI activation and performance. (2019)
  • Author(s): Ishihara, T., Miyazaki, A., Tanaka, H., Fujii, T., Takahashi, M., & Matsuda, T.
  • Organizer: Organization for Human Brain Mapping Annual Meeting
  • Int'l Joint Research
• [Presentation] 健常成人における体力・運動機能とワーキングメモリーの関係. (2019)
  • Author(s): 石原暢, 宮崎淳, 田中大貴, 藤井貴之, 高橋宗良，松田哲也
  • Organizer: 日本ヒト脳機能マッピング学会
• [Presentation] 中学生の体格と学業成績の関係：2年間の縦断的研究 (2019)
  • Author(s): 石原暢, 中島寿宏, 山津幸司, 沖田孝一, 佐川正人, 森田憲輝
  • Organizer: 日本発育発達学会
• [Presentation] Childhood sports and adulthood inhibition: A large-scale multimodal imaging study using HCP pipeline. (2018)
  • Author(s): Ishihara, T., Miyazaki, A., Takagishi, H., Fujii, T., Kanari, K., Nishina, K., Takahashi, M., Tanaka, H., Yamagishi, T., & Matsuda, T.
  • Organizer: Organization for Human Brain Mapping Annual Meeting
  • Int'l Joint Research
• [Presentation] 中学生の運動習慣と学業成績の関係：2年間の縦断的研究 (2018)
  • Author(s): 石原暢, 中島寿宏, 山津幸司, 沖田孝一, 佐川正人, 森田憲輝
  • Organizer: 北海道体育学会
• [Presentation] Influence of childhood exercise on cognitive functions and related brain structure and neural network in adulthood: Evaluation using Human Connectome Project pipeline (2018)
  • Author(s): Ishihara, T., Miyazaki, A., Takagishi, H., Fujii, T., Kanari, K., Nishina, K., Takahashi, M., Tanaka, H., Yamagishi, T., & Matsuda, T.
  • Organizer: Japan Neuroscience Society
• [Presentation] 中学生のラケット系運動部所属と体力・運動能力および学業成績の関係 (2018)
  • Author(s): 石原暢, 中島寿宏, 沖田孝一, 森田憲輝
  • Organizer: 日本テニス学会
• [Presentation] 実行機能とテニス競技パフォーマンスの関係 (2018)
  • Author(s): 石原暢, 黒田裕太
  • Organizer: 日本テニス学会
• [Book] 自己制御の発達と支援 (2018)
  • Author(s): 森口佑介, 本郷一夫, 石原暢, 紙上敬太
  • Total Pages: 120
  • Publisher: 金子書房
  • ISBN: 9784760895748