| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The fate of 1, 3-dimethylamylamine (DMAA), a prohibited substance to athletes, was evaluated by determining plasma concentrations, urinary excretion rate, and tissue distribution after intravenous, oral and transdermal administration in rats. DMAA administered intravenously disappeared from plasma according to a biexponential curve. During 6 h after intravenous administration, 35.2% of DMAA dose was excreted into urine as an intact form. Alkalized urine pH resulted in decreased urinary excretion rate and higher plasma concentrations of DMAA.The mean oral bioavailability of DMAA was 43.6%. When DMAA was applied to the skin, DMAA was recovered by 5.4% of dose in the urine for 7 days. In conclusion, DMAA was thought to be absorbed from anywhere, including the skin and distributed to various tissues. Long-term retention of DMAA in the body was, at least partly, due to the repeated reabsorption in renal tubules, though the extent of DMAA reabsorption depends on urine pH.
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