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Do the characteristics of deoxygenation response in active muscles reflect insufficient oxygen supply?

Research Project

Project/Area Number 18K17875
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionOsaka International University (2019-2023)
Kobe Design University (2018)

Principal Investigator

Okushima Dai  大阪国際大学, 人間科学部, 講師 (70735307)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords酸素動態 / 脱酸素化応答 / 近赤外分光法 / 近赤外時間分解分光法 / 筋酸素化動態 / 自転車運動 / 上肢自転車運動 / 下肢自転車運動 / 姿勢変化 / 近赤外線分光装置 / 筋酸素動態 / 酸素供給
Outline of Final Research Achievements

The deoxygenation response of active muscles during exercise, measured using a near-infrared spectroscopy device, reflects the balance of oxygen consumption relative to blood flow. In particular, muscles with a large amount of activity stagnate during high-intensity exercise, but it is unclear whether this response is related to insufficient oxygen supply to active muscles. We investigated the characteristics of the breakpoint in active muscle deoxygenation and its relationship to insufficient oxygen supply. As a result, it was revealed that the breakpoint in active muscle deoxygenation is not easily affected by exercise posture, exercise mode, or increased active muscle mass. These results suggest that the breakpoint in active muscle deoxygenation may reflect peripheral circulatory regulation function, which is less affected by exercise conditions than insufficient oxygen supply to active muscles.

Academic Significance and Societal Importance of the Research Achievements

本研究結果から、脱酸素化応答の停滞開始点が活動筋における酸素供給不足といった単純な反応を反映しない可能性が明らかとなった。また、運動条件による影響を受けにくい点や最大運動強度に近い高強度運動中に生じる点を考慮すると、全身の血液運搬能力が最大に近づく際に運動を継続するための末梢における循環・代謝調節機能と関連していると推察される。本研究の成果は、活動筋の末梢における循環・代謝調節メカニズムの解明に貢献するとともに、効果的な運動処方やトレーニング法を考える上でも有用な知見になり得ると考えられる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (49 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (15 results) Journal Article (14 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 12 results,  Open Access: 1 results) Presentation (14 results) (of which Int'l Joint Research: 8 results) Remarks (6 results)

  • [Int'l Joint Research] オランダ自由大学(オランダ)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] 湖北師範大学(中国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] リバプール・ホープ大学(英国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] カンザス州立大学(米国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] オランダ自由大学(オランダ)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] カンザス州立大学(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] リバプールホープ大学(英国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] カンザス州立大学/カリフォルニア大学ロサンゼルス校(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] リバプールホープ大学/リーズ大学(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] カンザス州立大学/インディアナ大学/NIH クリニカル・センター(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] オランダ自由大学(オランダ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] カンザス州立大学/カリフォルニア大学ロサンゼルス校(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] プリマス大学/エクセター大学/ラフバラ大学(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] カルガリー大学(カナダ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] KUルーベン大学(ベルギー)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Time to retire the notion that local and whole-body exercise thresholds are mechanistically linked?2023

    • Author(s)
      Goulding RP, Marwood S, Lei TH, Okushima D, Poole DC, Barstow TJ, Kondo N, Koga S.
    • Journal Title

      Eur J Appl Physiol

      Volume: 123 Issue: 2 Pages: 419-420

    • DOI

      10.1007/s00421-022-05082-3

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 運動開始時の呼吸の動的調節.2022

    • Author(s)
      奥島大、古賀俊策
    • Journal Title

      体育の科学

      Volume: 72 Pages: 670-674

    • Related Report
      2022 Research-status Report
  • [Journal Article] Influence of exercise intensity and regional differences in the sudomotor recruitment pattern in exercising prepubertal boys and young men2022

    • Author(s)
      Amano Tatsuro、Asami Takako、Ichinose-Kuwahara Tomoko、Okushima Dai、Ueda Hiroyuki、Kondo Narihiko、Inoue Yoshimitsu
    • Journal Title

      Physiology & Behavior

      Volume: 243 Pages: 113642-113642

    • DOI

      10.1016/j.physbeh.2021.113642

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dissociation between exercise intensity thresholds: mechanistic insights from supine exercise.2021

    • Author(s)
      Goulding RP, Marwood S, Lei TH, Okushima D, Poole DC, Barstow TJ, Kondo N, Koga S.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 321 Issue: 5 Pages: 712-722

    • DOI

      10.1152/ajpregu.00096.2021

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The effect of seasonal acclimatization on whole body heat loss response during exercise in a hot humid environment with different air velocity2021

    • Author(s)
      Lei Tze-Huan、Fujiwara Masashi、Gerrett Nicola、Amano Tatsuro、M?ndel Toby、Inoue Yoshimitsu、Okushima Dai、Nishiyasu Takeshi、Kondo Narihiko
    • Journal Title

      Journal of Applied Physiology

      Volume: 131 Issue: 2 Pages: 520-531

    • DOI

      10.1152/japplphysiol.00837.2020

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of supine versus upright exercise on muscle deoxygenation heterogeneity during ramp incremental cycling is site specific.2021

    • Author(s)
      Goulding RP, Okushima D, Fukuoka Y, Marwood S, Kondo N, Poole DC, Barstow TJ, and Koga S.
    • Journal Title

      European Journal of Applied Physiology

      Volume: 10.1007/s00421-021-04607-6 Issue: 5 Pages: 1-14

    • DOI

      10.1007/s00421-021-04607-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of supine exercise on muscle deoxygenation kinetics heterogeneity: mechanistic insights into slow pulmonary oxygen uptake dynamics.2020

    • Author(s)
      Goulding RP, Okushima D, Marwood S, Poole DC, Barstow TJ, Lei T-H, Kondo N, and Koga S.
    • Journal Title

      Journal of Applied Physiology

      Volume: 129 Issue: 3 Pages: 535-546

    • DOI

      10.1152/japplphysiol.00213.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of priming exercise and body position on pulmonary oxygen uptake and muscle deoxygenation kinetics during cycle exercise.2020

    • Author(s)
      Goulding RP, Marwood S, Okushima D, Poole DC, Barstow TJ, Lei T-H, Kondo N, and Koga S.
    • Journal Title

      Journal of Applied Physiology

      Volume: 129 Issue: 4 Pages: 810-822

    • DOI

      10.1152/japplphysiol.00478.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of differential muscle activation patterns on muscle deoxygenation and microvascular haemoglobin regulation2020

    • Author(s)
      Okushima Dai、Poole David C.、Barstow Thomas J.、Kondo Narihiko、Chin Lisa M. K.、Koga Shunsaku
    • Journal Title

      Experimental Physiology

      Volume: 105 Issue: 3 Pages: 531-541

    • DOI

      10.1113/ep088322

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Autonomic and perceptual thermoregulatory responses to voluntarily engaging in a common thermoregulatory behaviour2020

    • Author(s)
      Lei Tze-Huan、Matsukawa Hiroki、Okushima Dai、Gerrett Nicola、Schlader Zachary J.、M?ndel Toby、Fujiwara Masashi、Kondo Narihiko
    • Journal Title

      Physiology & Behavior

      Volume: 215 Pages: 112768-112768

    • DOI

      10.1016/j.physbeh.2019.112768

    • Related Report
      2019 Research-status Report
  • [Journal Article] Unaltered VO2 kinetics despite greater muscle oxygenation during heavy-intensity two-legged knee extension versus cycle exercise in humans2019

    • Author(s)
      Koga S, Okushima D, Poole DC, Rossiter HB, Kondo N, Barstow TJ
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 316 Issue: 1 Pages: R203-R213

    • DOI

      10.1152/ajpregu.00015.2019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Blood flow occlusion-related O2 extraction "reserve" is present in different muscles of the quadriceps but greater in deeper regions after ramp-incremental test.2018

    • Author(s)
      Iannetta D, Okushima D, Inglis EC, Kondo N, Murias JM, Koga S.
    • Journal Title

      J Appl Physiol

      Volume: 125 Issue: 2 Pages: 313-319

    • DOI

      10.1152/japplphysiol.00154.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of dietary nitrate supplementation on local sweating and cutaneous vascular responses during exercise in a hot environment2018

    • Author(s)
      Amano Tatsuro、Okushima Dai、Breese Brynmor C.、Bailey Stephen J.、Koga Shunsaku、Kondo Narihiko
    • Journal Title

      European Journal of Applied Physiology

      Volume: 118 Issue: 8 Pages: 1579-1588

    • DOI

      10.1007/s00421-018-3889-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reply to Dr. Grassi2018

    • Author(s)
      Iannetta Danilo、Okushima Dai、Inglis Erin Calaine、Koga Shunsaku、Murias Juan M.
    • Journal Title

      Journal of Applied Physiology

      Volume: 125 Issue: 4 Pages: 1356-1356

    • DOI

      10.1152/japplphysiol.00826.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Influence Of Body Position On Pulmonary Oxygen Uptake And Muscle Deoxygenation Kinetics During Cycle Exercise2020

    • Author(s)
      Goulding Richie P.、Okushima Dai、Marwood Simon、Lei Tze-Huan、Kondo Narihiko、Poole David C.、Barstow Thomas J.、Koga Shunsaku
    • Organizer
      67th American College of Sports Medicine Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Contrasting Patterns Of Respiratory And Locomotor Muscle Deoxygenation And Total Hemoglobin During Incremental Ramp Cycling2020

    • Author(s)
      Okushima Dai, Bowen T. Scott, Barstow Thomas J, Poole David C., Rossiter Harry B., Kondo Narihiko, Koga Shunsaku
    • Organizer
      67th American College of Sports Medicine Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence Of Priming Exercise On Muscle Deoxygenation Kinetics During Upright And Supine Cycle Exercise2020

    • Author(s)
      Koga Shunsaku, Okushima Dai, Marwood Simon, Lei Tze-Tuan, Kondo Narihiko, Poole David C., Barstow Thomas J., Richie Goulding P.
    • Organizer
      67th American College of Sports Medicine Annual Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of respiratory muscle activation on the blood volume in locomotor muscle during incremental ramp cycling2019

    • Author(s)
      Dai Okushimaa, Narihiko Kondo, Yoshimitsu Inoue, Yukio Ogura, Shunsaku Koga
    • Organizer
      International Conference on Environmental Ergonomics 2019 Amsterdam
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of using an electric fan in front of upper body on sweating efficiency during exercise in hot humid environment2019

    • Author(s)
      Masashi Fujiwara, Tze-Huan Lei, Dai Okushima, Nicola Gerrett, Takeshi Nishiyasu, Yoshimitsu Inoue, Narihiko Kondo
    • Organizer
      International Conference on Environmental Ergonomics 2019 Amsterdam
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characteristic of human behavioural thermoregulation of clothing removal during and after exercise: effect of thermal perceptions and autonomic function2019

    • Author(s)
      Tze-Huan Lei, Hiroki Matsukawa, Masashi Fujiwara, Dai Okushima, Zachary Schlader, Nicola Gerrett, Narihiko Kondo
    • Organizer
      International Conference on Environmental Ergonomics 2019 Amsterdam
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高強度インターバルトレーニングが漸増負荷運動中の酸素動態の応答特性に及ぼす影響2019

    • Author(s)
      奥島大,西脇雅人,近藤徳彦,古賀俊策
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 季節順化が高温高湿下における運動時の有効・無効発汗量に及ぼす影響2019

    • Author(s)
      藤原雅志,雷子煥,奥島大,天野達郎,西保岳,井上芳光,近藤徳彦
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 夏への季節変化が高温高湿下における運動時の有効・無効発汗量に及ぼす影響2019

    • Author(s)
      藤原雅志,雷子煥,奥島大,天野達郎,西保岳,井上芳光,近藤徳彦
    • Organizer
      第33回運動と体温の研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 漸増負荷運動時の呼吸筋の賦活が外側広筋の組織血液量に及ぼす影響2018

    • Author(s)
      奥島大,近藤徳彦,古賀俊策
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高温下での運動時の発汗効率に影響する要因2018

    • Author(s)
      藤原雅志,奥島大,天野達郎,西保岳,井上芳光,近藤徳彦
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Buffer room入室介入の有無が喘息体質者の運動時の肺機能変化に及ぼす影響2018

    • Author(s)
      高木祐介,山本正嘉,奥島大,北哲也,森寿仁,家吉彩夏,幸田三広,諸井美樹,小野寺昇
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Do contrasting recruitment patterns underlie the different patterns of muscle deoxygenation and hemoglobin response in quadriceps muscles?2018

    • Author(s)
      Okushima D, Poole DC, Barstow TJ, Kondo N, and Koga S
    • Organizer
      65th American College of Sports Medicine Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of inorganic nitrate supplementation on O2 uptake and quadriceps deoxygenation during the onset and offset of exercise2018

    • Author(s)
      Breeze BC, Poole DC, Okushima D, Bailey SJ, Jones A, Kondo N, Amano T, and Koga S
    • Organizer
      65th American College of Sports Medicine Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks]

    • URL

      https://orcid.org/0000-0001-7988-3536

    • Related Report
      2021 Research-status Report
  • [Remarks]

    • URL

      https://www.oiu.ac.jp/gakubu/ningen/sports/okushima.html

    • Related Report
      2021 Research-status Report
  • [Remarks]

    • URL

      https://orcid.org/0000-0001-7988-3536

    • Related Report
      2020 Research-status Report
  • [Remarks]

    • URL

      https://www.oiu.ac.jp/gakubu/ningen/sports/okushima.html

    • Related Report
      2020 Research-status Report
  • [Remarks] ORCID

    • URL

      https://orcid.org/0000-0001-7988-3536

    • Related Report
      2019 Research-status Report
  • [Remarks]

    • URL

      https://scholar.google.co.jp/citations?user=_0YEkEIAAAAJ&hl=ja

    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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