Clinical development of electroencephalogram analysis method based on the corticothalamic model

• Project/Area Number: 18K17887
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59030:Physical education, and physical and health education-related
• Research Institution: The University of Tokyo
• Principal Investigator: Yamaguchi Ikuhiro 東京大学, 大学院教育学研究科(教育学部), 特任助教 (30735163)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: モデルベース型 / データ駆動型 / 皮質 / 視床 / 相転移 / 潜在的意味解析 / 縦断的 / 脳波 / 睡眠 / 覚醒 / 特異値分解 / 動的モード分解 / 名義データ / てんかん / 超概日リズム / 皮質視床系 / 脳波モデル / 物理学的 / 時系列 / 皮質-視床系 / 認知症

Outline of Final Research Achievements

(1) Construction of a physical model of focal epilepsy using a cortical thalamic model; a theory of focal epilepsy was constructed from a model-based approach by following the phase transition theory in physics. (2) Proposal of circadian/ultradian rhythm extraction method from sleep stage time series data; a new extraction method of the rhythms was proposed from a data-driven approach by performing latent semantic analysis using the sleep stage as a nominal scale. (3) Measurement of salivary alpha-amylase to support person-centered care for individuals with dementia; it was shown that analyzing longitudinal data for each patient can be a help of person-centered care according to the individuality of person.

Academic Significance and Societal Importance of the Research Achievements

身体活動あるいは疾患に関するデータの捉え方は、モデルベース型とデータ駆動型といったアプローチの違い、また数理、物理、生理、心理といった分野の違い、さらには大学と医療現場といった組織の違いにより、多様なものになっている。本研究においては、そのような多様な内容について、それらを融合する立場を取った。今後社会的にパーソンセンタードケアを発展させていく基盤構築の一助になった。

Research Products

• [Journal Article] Early Warning Signals Observed in Psycho-Behavioral Intensive Longitudinal Data for the Onset and Pathological Phase Transition of Psychiatric Disorders and Their Applicability to Very Early Intervention (2019)
  • Author(s): 志村 広子、中村 亨、山口 郁博、山本 義春
  • Journal Title: Journal of The Society of Instrument and Control Engineers Volume: 58 Issue: 2 Pages: 102-108
  • DOI: 10.11499/sicejl.58.102
  • NAID: 130007604815
  • ISSN: 0453-4662, 1883-8170
  • Year and Date: 2019-02-10
  • Peer Reviewed
• [Journal Article] Suppression of Macroscopic Oscillations in Mixed Populations of Active and Inactive Oscillators Coupled through Lattice Laplacian (2019)
  • Author(s): Ikuhiro Yamaguchi, Takuya Isomura, Hiroya Nakao, Yutaro Ogawa, Yasuhiko Jimbo, Kiyoshi Kotani
  • Journal Title: Journal of the Physical Society of Japan Volume: 88 Issue: 5 Pages: 054004-054004
  • DOI: 10.7566/jpsj.88.054004
  • NAID: 40021885761
  • Peer Reviewed / Open Access
• [Journal Article] Drinking levels and profiles of alcohol addicted rats predict response to nalmefene (2019)
  • Author(s): J. C. Foo, V. Vengeliene, H. R. Noori, I. Yamaguchi, K. Morita, T. Nakamura, Y. Yamamoto, R. Spanagel
  • Journal Title: Frontiers in Pharmacology Volume: 10 Pages: 471-471
  • DOI: 10.3389/fphar.2019.00471
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Markov modeling of sleep stage transitions and ultradian REM sleep rhythm (2018)
  • Author(s): Kishi Akifumi、Yamaguchi Ikuhiro、Togo Fumiharu、Yamamoto Yoshiharu
  • Journal Title: Physiological Measurement Volume: 39 Issue: 8 Pages: 084005-084005
  • DOI: 10.1088/1361-6579/aad900
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cortico-Thalamo-Cortical Loop Strength Estimation using EEG: Investigation to Clinical Application (2018)
  • Author(s): 山口 郁博、岸 哲史、東郷 史治、中村 亨、山本 義春
  • Journal Title: Transactions of Japanese Society for Medical and Biological Engineering Volume: Annual56 Issue: Abstract Pages: S235-S235
  • DOI: 10.11239/jsmbe.Annual56.S235
  • NAID: 130007483698
  • ISSN: 1347-443X, 1881-4379
• [Presentation] Method to extract latent semantic components from noisy categorical time-series data applied to human sleep stage data (2019)
  • Author(s): Ikuhiro Yamaguchi, Akifumi Kishi, Fumiharu Togo, Yoshiharu Yamamoto
  • Organizer: 25th International Conference on Noise and Fluctuations ICNF 2019
  • Int'l Joint Research
• [Presentation] 認知症の経過を物語としてとらえ、強みを見出すことの試み (2019)
  • Author(s): 管谷由紀子、尾方睦望、辻正純、黒宮寛之、山口郁博
  • Organizer: 第9回日本認知症予防学会学術集会
• [Presentation] 唾液アミラーゼによる集団音楽療法 での個性の可視化 ～A氏の強みを生かすことができた1例～ (2019)
  • Author(s): 尾方睦望、辻正純、管谷由紀子、山口郁博
  • Organizer: 第9回日本認知症予防学会学術集会
• [Presentation] Method to extract latent semantic components from noisy categorical time-series data applied to human sleep stage data (2019)
  • Author(s): Ikuhiro Yamaguchi, Akifumi Kishi, Fumiharu Togo, Yoshiyuki Yamamoto
  • Organizer: International Conference on Noise and Fluctuation
  • Int'l Joint Research
• [Presentation] Measurements of salivary alpha-amylase to assist in person-centered care for people with dementia (2019)
  • Author(s): Ikuhiro Yamaguchi, Yukiko Sugaya, Mutsumi Ogata
  • Organizer: IEEE LifeTech
  • Int'l Joint Research
• [Presentation] 唾液アミラーゼ活性測定による個性の抽出 (2019)
  • Author(s): 山口郁博、管谷由紀子、尾方睦望
  • Organizer: 情報処理学会
• [Presentation] 皮質-視床-皮質ループ強度の脳波による推定：医用展開に向けた検討 (2018)
  • Author(s): 山口 郁博、岸 哲史、東郷 史治、中村 亨、山本 義春
  • Organizer: 生体医工学会
• [Presentation] 認知症者に寄り添うケア技法の開発と形式知化 - 臨床美術士の立場から - (2018)
  • Author(s): 内田栄子、管谷由紀子、小山雅乃1 及部智子 辻正純 山口郁博
  • Organizer: 認知症予防学会
• [Presentation] 集団音楽療法における「認知的働きかけ」の導入 (2018)
  • Author(s): 尾方睦望、管谷由紀子、辻正純、山口郁博
  • Organizer: 認知症予防学会
• [Presentation] 唾液アミラーゼと計量テキストを量的データとする物語研究 -あるデイサービス利用者を主人公として - (2018)
  • Author(s): 管谷由紀子、尾方睦望、山口郁博
  • Organizer: 混合研究法学会