Manipulation of sleep dynamics using noninvasive brain stimulation

• Project/Area Number: 18K17891
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59030:Physical education, and physical and health education-related
• Research Institution: The University of Tokyo
• Principal Investigator: Kishi Akifumi 東京大学, 大学院教育学研究科(教育学部), 助教 (70748946)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 睡眠 / 非侵襲的脳刺激 / 非侵襲的脳刺激法 / 脳波

Outline of Final Research Achievements

The purpose of this study was to develop a method for controlling sleep dynamics using noninvasive brain stimulation. We found that noninvasive brain stimulation at specific frequencies during sleep may improve subjective and objective sleep quality. In addition, we constructed a dynamic model of sleep stage transitions (Kishi et al., 2018). We also characterized altered sleep dynamics in patients with sleep bruxism (Kishi et al., 2020).

Academic Significance and Societal Importance of the Research Achievements

本研究では、適切な脳状態修飾により、睡眠の質が改善され得ることが明らかになった。これは、睡眠中の脳状態制御が可能であることを示唆するとともに、良質な睡眠の獲得に資する新たな技術開発につながる点で学術的・社会的意義を有するものと考えられる。

Research Products

• [Int'l Joint Research] マウントサイナイ医科大学(米国)
• [Journal Article] ICT/IoT技術を用いた睡眠改善法の展望：精神疾患の予防に向けて (2021)
  • Author(s): 岸哲史，竹内皓紀，中村亨，吉内一浩，山本義春
  • Journal Title: 精神科 Volume: 39 Pages: 623-629
• [Journal Article] Discrepancies in the time course of sleep stage dynamics, electroencephalographic activity and heart rate variability over sleep cycles in the adaptation night in healthy young adults. (2021)
  • Author(s): Shirota, A., M. Kamimura, A. Kishi, H. Adachi, M. Taniike, T. Kato.
  • Journal Title: Frontiers in Physiology Volume: 12 Pages: 1-11
  • DOI: 10.3389/fphys.2021.623401
  • Peer Reviewed / Open Access
• [Journal Article] Sleep stage dynamics in young patients with sleep bruxism (2020)
  • Author(s): Kishi Akifumi、Haraki Shingo、Toyota Risa、Shiraishi Yuki、Kamimura Mayo、Taniike Masako、Yatani Hirofumi、Kato Takafumi
  • Journal Title: Sleep Volume: 43 Issue: 1 Pages: 1-12
  • DOI: 10.1093/sleep/zsz202
  • Peer Reviewed / Open Access
• [Journal Article] Association of depressive symptoms with habitual sleep duration and sleep timing in junior high school students (2020)
  • Author(s): Ojio Yasutaka、Kishi Akifumi、Sasaki Tsukasa、Togo Fumiharu
  • Journal Title: Chronobiology International Volume: - Issue: 6 Pages: 1-10
  • DOI: 10.1080/07420528.2020.1746796
  • Peer Reviewed
• [Journal Article] Markov modeling of sleep stage transitions and ultradian REM sleep rhythm (2018)
  • Author(s): Kishi Akifumi、Yamaguchi Ikuhiro、Togo Fumiharu、Yamamoto Yoshiharu
  • Journal Title: Physiological Measurement Volume: 39 Issue: 8 Pages: 084005-084005
  • DOI: 10.1088/1361-6579/aad900
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Sleep stage dynamics in patients with narcolepsy and other hypersomnias (2021)
  • Author(s): 岸哲史，北島剛司，河合諒子，廣瀬真里奈，岩田仲生，山本義春
  • Organizer: 日本睡眠学会第46回定期学術集会
• [Presentation] ヒト睡眠ダイナミクスの機序解明と操作への展望 (2021)
  • Author(s): 岸哲史
  • Organizer: 第29回身体運動科学公開シンポジウム
  • Invited
• [Presentation] Dynamics of sleep stage transitions in patients with narcolepsy and other hypersomnias. (2020)
  • Author(s): Kishi, A., T. Kitajima, R. Kawai, M. Hirose, N. Iwata, Y. Yamamoto.
  • Organizer: The SLEEP 2020 34th Annual Meeting of the Associated Professional Sleep Societies, LLC
  • Int'l Joint Research
• [Presentation] Bayesian estimation for circadian phase and sleep-related parameter using actigraphy data. (2020)
  • Author(s): Takeuchi, H., A. Kishi, M. Hirose, T. Nakamura, T. Kitajima, Y. Yamamoto.
  • Organizer: 第27回日本時間生物学会学術大会
• [Presentation] Can affective computing better the mental status of the computer games player? A perspective. (2020)
  • Author(s): Wang, Y., K. Qian, J. Nelson, H. Yagi, A. Kishi, K. Morita, Y. Yamamoto.
  • Organizer: The 2020 IEEE 2nd Global Conference on Life Sciences and Technologies (LifeTech 2020)
  • Int'l Joint Research
• [Presentation] Daily association between presenteeism and momentary mood, physical symptoms, and pain. (2020)
  • Author(s): Suwa, K., A. Kishi, K. Yoshiuchi, Y. Yamamoto.
  • Organizer: The Society of Behavioral Medicine’s 41st Annual Meeting & Scientific Sessions
  • Int'l Joint Research
• [Presentation] A novel method for estimating endogenous circadian rhythm using actigraphy data. (2020)
  • Author(s): Takeuchi, H., A. Kishi, M. Hirose, T. Nakamura, T. Kitajima, Y. Yamamoto.
  • Organizer: The 2020 Society for Research on Biological Rhythms
  • Int'l Joint Research
• [Presentation] Method to extract latent semantic components from noisy categorical time-series data applied to human sleep stage data (2019)
  • Author(s): Yamaguchi, I., A. Kishi, F. Togo, Y. Yamamoto.
  • Organizer: The 25th International Conference on Noise and Fluctuations
  • Int'l Joint Research
• [Presentation] The effect of mood status on the subjective-objective sleep discrepancy in healthy young subjects: A multilevel modeling approach (2019)
  • Author(s): Kishi, A., Y. Miyake.
  • Organizer: World Sleep 2019
  • Int'l Joint Research
• [Presentation] Association of emotional and behavioral difficulties with insomnia symptoms, sleep duration, and sleep timing among children. (2019)
  • Author(s): Sarah Sabouri，小塩靖崇，岸 哲史，東郷史治.
  • Organizer: 日本睡眠学会第44回定期学術集会
• [Presentation] Dynamics of sleep stage transitions: Toward understanding the basic physiology and clinical aspects of sleep in humans (2018)
  • Author(s): Kishi, A.
  • Organizer: International Congress on Biological and Medical Sciences 2018
  • Int'l Joint Research / Invited
• [Presentation] Sleep stage dynamics in patients with sleep bruxism (2018)
  • Author(s): Kishi, A., T. Kato.
  • Organizer: The SLEEP 2018 32nd Annual Meeting of the Associated Professional Sleep Societies, LLC.
  • Int'l Joint Research
• [Presentation] Association of depressive symptoms with sleep duration and timing in Japanese adolescents (2018)
  • Author(s): Ojio, Y., S. Sabouri, A. Kishi, F. Togo.
  • Organizer: The 9th Congress of Asian Sleep Research Society
  • Int'l Joint Research
• [Presentation] The mood of happiness on awakening predicts the discrepancy between subjective and objective sleep duration in healthy young adults (2018)
  • Author(s): Kishi, A., Y. Miyake.
  • Organizer: The 9th Congress of Asian Sleep Research Society
  • Int'l Joint Research
• [Presentation] 皮質-視床-皮質ループ強度の脳波による推定：医用展開に向けた検討 (2018)
  • Author(s): 山口郁博，岸 哲史，東郷史治，中村 亨，山本義春．
  • Organizer: 第57回日本生体医工学会大会・オーガナイズドセッション「生体信号計測・解釈」
• [Book] Chronic fatigue syndrome and fibromyalgia. In: Handbook of Sleep Disorders in Medical Conditions. (2019)
  • Author(s): Togo, F., A. Kishi, B. H. Natelson.
  • Publisher: Academic Press
  • ISBN: 9780128130148