The use of real world data for evaluating the risk factors for vascular complications and progression in non-communicable diseases
Project/Area Number |
18K17897
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 59030:Physical education, and physical and health education-related
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Research Institution | Niigata University |
Principal Investigator |
Fujihara Kazuya 新潟大学, 医歯学総合研究科, 特任准教授 (10779341)
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Project Period (FY) |
2018-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 医療ビッグデータ / データサイエンス / リアルワールドデータ / ビックデータ / レセプト / 機械学習 / 遺伝情報 |
Outline of Final Research Achievements |
Although there are a number of diabetic cardiovascular disease clinical studies being conducted around the world, clinical studies face a large cost, enormous effort and cooperation of subjects. In order to resolve such issues it is essential to use new and alternative research sources such as big data. Big data has the following characteristics that can complement above issues: be available existing data set, no need a large cost, be available data accumulated over a long period, expecting to increase in events as time passed. We analyzed data using a nationwide claim-based database in Japan and clarified the risk factors for micro/macro vascular disease in real worlds data.
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Academic Significance and Societal Importance of the Research Achievements |
健診結果と診療報酬明細書の結果を突合した医療ビッグデータベースを作成し、糖尿病をはじめとした生活習慣病領域において、冠動脈疾患、細小血管合併症のリスクの評価を行った。具体的には、1.糖尿病と冠動脈疾患(CAD)の既往がその後のCADイベントに及ぼす影響の検討 2.糖尿病の有無別にみた血糖・血圧・脂質・喫煙の各管理目標達成(状況)がCADに及ぼす影響 3.糖尿病の治療状況と冠動脈疾患、重症視力障害発症の関連の検討 4. 糖尿病患者における脈圧が重症視力障害・透析発症に及ぼす影響の検討 を行い、論文報告を行った。
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Report
(3 results)
Research Products
(51 results)
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[Journal Article] Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study2019
Author(s)
Momma H, Sawada SS, Kato K, Gando Y, Kawakami R, Miyachi M, Huang C, Nagatomi R, Tashiro M, Ishizawa M, Kodama S, Iwanaga M, Fujihara K, Sone H
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Journal Title
Journal of Epidemiology
Volume: 29
Issue: 4
Pages: 139-146
DOI
NAID
ISSN
0917-5040, 1349-9092
Year and Date
2019-04-05
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between Number of Multiple Risk Factors and Coronary Artery Disease Risk With and Without Diabetes Mellitus2019
Author(s)
Harada M, Fujihara K, Osawa T, Yamamoto M, Kaneko M, Kitazawa M, Matsubayashi Y, Yamada T, Yamanaka N, Seida H, Ogawa W, Sone H
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Journal Title
J Clin Endocrinol Metab
Volume: in press
Issue: 11
Pages: 5084-5090
DOI
Related Report
Peer Reviewed
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[Journal Article] Risk of coronary artery disease according to glucose abnormality status and prior coronary artery disease in Japanese men2019
Author(s)
Kitazawa M, Fujihara K, Osawa T, Yamamoto M, Yamada MH, Kaneko M, Matsubayashi Y, Yamada T, Yamanaka N, Seida H, Sone H
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Journal Title
Metabolism
Volume: -
Pages: 153991-153991
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pulse Pressure is a Stronger Predictor Than Systolic Blood Pressure for Severe Eye Diseases in Diabetes Mellitus2019
Author(s)
Yamamoto M, Fujihara K, Ishizawa M, Osawa T, Kaneko M, Ishiguro H, Matsubayashi Y, Seida H, Yamanaka N, Tanaka S, Kodama S, Hasebe H, Sone H
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Journal Title
J Am Heart Assoc
Volume: 8(8)
Issue: 8
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Combined Effects of Energy Intake and Physical Activity on Obesity in Japanese Patients with Type 2 Diabetes (JDDM 50): A Cross-Sectional Study2019
Author(s)
Hatta M, Fujihara K, Morikawa SY, Takeda Y, Ishii D, Horikawa C, Kato, M, Yokoyama H, Kurihara Y, Iwasaki K, Miyazawa K, Yamazaki K, Tanaka S, Maegawa H, Sone H
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Journal Title
Diabetes Ther
Volume: 印刷中
Issue: 3
Pages: 1133-1138
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of family-oriented diabetes programs on glycemic control: A meta-analysis.2018
Author(s)
Kodama S, Morikawa S, Horikawa C, Ishii D, Fujihara K, Yamamoto M, Osawa T, Kitazawa M, Yamada T, Kato K, Tanaka S and Sone H.
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Journal Title
Fam Pract.
Volume: 12
Issue: 4
Pages: 111-111
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis2018
Author(s)
Kodama S, Horikawa C, Fujihara K, Ishii D, Hatta M, Takeda Y, Kitazawa M, Matsubayashi Y, Shimano H, Kato K, Tanaka S, Sone H
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Journal Title
Clin Nutr ESPEN
Volume: 27
Pages: 53-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2.2018
Author(s)
Morikawa SY, Fujihara K, Hatta M, Osawa T, Ishizawa M, Yamamoto M, Furukawa K, Ishiguro H, Matsunaga S, Ogawa Y, Shimano H, Sone H.
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Journal Title
Pediatr Diabetes.
Volume: 印刷中
Issue: 4
Pages: 593-602
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Meat intake and incidence of cardiovascular disease in Japanese patients with type 2 diabetes: analysis of the Japan Diabetes Complications Study (JDCS).2018
Author(s)
Horikawa C, Kamada C, Tanaka S, Tanaka S, Araki A, Ito H, Matsunaga S, Fujihara K, Yoshimura Y, Ohashi Y, Akanuma Y, Sone H, Japan Diabetes Complications Study Group.
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Journal Title
Eur J Nutr.
Volume: 印刷中
Issue: 1
Pages: 281-90
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes: analysis using a nationwide claim database2018
Author(s)
Osawa T, Fujihara K, Yamamoto M, Harada M, Ishizawa M, Seida H, Yamanaka N, Matsubayashi Y, Matsunaga S, Yamada T, Sone H
Organizer
54th Annual Meeting of the European Association for the Study of Diabetes
Related Report
Int'l Joint Research
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[Presentation] Effects of treatment-achieved HbA1c on incidence of micro-/macrovascular complications in patients with diabetes2018
Author(s)
Harada M, Fujihara K, Osawa T, Yamamoto M, Kaneko M, Ishizawa M, Matsubayashi Y, Yamada T, Yamanaka N, Hiroyasu S, Kodama S, Sone H
Organizer
54th Annual Meeting of the European Association for the Study of Diabetes
Related Report
Int'l Joint Research
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[Presentation] Effects of Treatment-Achieved HbA1c on Incidence of Micro-/Macrovascular Complications in Patients with Diabetes Mellitus2018
Author(s)
Harada M, Fujihara K, Osawa T, Yamamoto M, Kaneko M, Matsubayashi Y, Matsunaga S, Yamada T, Yamanaka N, Seida H, Kodama S, Sone H
Organizer
78th American Diabetes Association Scientific Sessions (ADA)
Related Report
Int'l Joint Research
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[Presentation] Effect of Number of Achieved Targets for Risk Factors on Coronary Artery Disease (CAD) in Those With and Without Diabetes Mellitus (DM)2018
Author(s)
Fujihara K, Matsubayashi Y, Kitazawa M, Yamamoto M, Osawa T, Kaneko M, Yamanaka N, Seida H, Kato K, Kodama S, Sone H
Organizer
78th American Diabetes Association Scientific Sessions (ADA)
Related Report
Int'l Joint Research
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[Presentation] Reduced Postprandial Hepatic Insulin Clearance via the DPP-4 Inhibitor Anagliptin Contributed to Improvement in Hyperglycemia in Patients with Type 2 Diabetes Mellitus2018
Author(s)
Matsubayashi Y, Abe T, Muragishi S, Yoshida A, Suganami H, FurusawaK, Yamada T, Fujihara K, Tanaka S, Kaku K, Sone H
Organizer
78th American Diabetes Association Scientific Sessions (ADA)
Related Report
Int'l Joint Research
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[Presentation] Test Strip-Positive Proteinuria and Its Combination with Low eGFR Are Predictive of Treatment-Required Eye Diseases in Japanese Patients with Diabetes Mellitus2018
Author(s)
Yamamoto M, Fujihara K, Osawa T, Harada M, Ishizawa M, Ishiguro H, Suzuki H, Seida H, Yamanaka N, Matsubayashi Y, Sone H
Organizer
78th American Diabetes Association Scientific Sessions (ADA)
Related Report
Int'l Joint Research
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